公开(公告)号：US20110178099A1

公开(公告)日：2011-07-21

申请号：US12995882

申请日：2009-06-04

申请人： Martin Friedrich Stefanic ,  Frank Hilberg ,  Rolf Kaiser ,  David Shapiro

发明人： Martin Friedrich Stefanic ,  Frank Hilberg ,  Rolf Kaiser ,  David Shapiro

IPC分类号： A61K31/519 ,  A61P3/10 ,  A61P35/00 ,  A61P17/06 ,  A61P29/00 ,  A61P37/06 ,  A61P27/02

CPC分类号： A61K31/519 ,  A61K9/4858 ,  A61K31/496 ,  A61N5/10 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve migration or apoptosis of myeloma cells, which involve angiogenesis or which involve fibrosis. The invention also relates to a method for the treatment of said diseases, comprising simultaneous, separate or sequential administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

摘要翻译： 本发明涉及可用于治疗涉及涉及血管生成或涉及纤维化的骨髓瘤细胞迁移或凋亡的细胞增殖的疾病的药物组合。 本发明还涉及一种用于治疗所述疾病的方法，包括以提供添加剂和协同效应的比例同时，分别或连续施用有效量的特定活性化合物和/或与放射治疗共同治疗，以及 将这些特定化合物和/或放射疗法的组合使用用于制造相应的药物组合制剂。

公开(公告)号：US20080254040A1

公开(公告)日：2008-10-16

申请号：US12140661

申请日：2008-06-17

申请人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

发明人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

IPC分类号： A61K39/395 ,  A61K31/496 ,  A61K38/19 ,  A61K31/553 ,  A61P35/00 ,  A61K31/517 ,  A61K38/43

CPC分类号： A61K31/496 ,  A61K31/404 ,  A61K31/517 ,  A61K31/553 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said diseases, comprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

摘要翻译： 本发明涉及用于治疗涉及骨髓瘤细胞的细胞增殖，迁移或凋亡或血管发生的疾病的药物组合。 本发明还涉及一种治疗所述疾病的方法，包括以提供添加剂和协同效应的比例共同给予有效量的特定活性化合物和/或与放射治疗共同给药，以及组合 使用这些特定化合物和/或放射治疗来制造相应的药物组合制剂。

公开(公告)号：US20140057898A1

公开(公告)日：2014-02-27

申请号：US14071166

申请日：2013-11-04

申请人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

发明人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

IPC分类号： A61K31/496 ,  A61K31/553

CPC分类号： A61K31/496 ,  A61K31/404 ,  A61K31/517 ,  A61K31/553 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said diseases, comprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

摘要翻译： 本发明涉及用于治疗涉及骨髓瘤细胞的细胞增殖，迁移或凋亡或血管发生的疾病的药物组合。 本发明还涉及一种治疗所述疾病的方法，包括以提供添加剂和协同效应的比例共同给予有效量的特定活性化合物和/或与放射治疗共同给药，以及组合 使用这些特定化合物和/或放射治疗来制造相应的药物组合制剂。

公开(公告)号：US20130237549A1

公开(公告)日：2013-09-12

申请号：US13869139

申请日：2013-04-24

申请人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Rolf KAISER ,  David SHAPIRO

发明人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Rolf KAISER ,  David SHAPIRO

IPC分类号： A61K31/519 ,  A61K31/496

CPC分类号： A61K31/519 ,  A61K9/4858 ,  A61K31/496 ,  A61N5/10 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve migration or apoptosis of myeloma cells, which involve angiogenesis or which involve fibrosis. The invention also relates to a method for the treatment of said diseases, comprising simultaneous, separate or sequential administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

公开(公告)号：US20110171289A1

公开(公告)日：2011-07-14

申请号：US12912110

申请日：2010-11-09

申请人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

发明人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

IPC分类号： A61K9/127 ,  A61K31/502 ,  A61K31/5377 ,  A61K31/395 ,  A61K31/506 ,  A61K31/675 ,  A61K33/24 ,  A61K31/7008 ,  A61K31/66 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7076 ,  A61K38/14 ,  A61K38/21 ,  A61K31/57 ,  A61K38/20 ,  A61K38/16 ,  A61K39/395 ,  A61P35/00 ,  A61P35/02

CPC分类号： A61K31/496 ,  A61K31/404 ,  A61K31/517 ,  A61K31/553 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said diseases, comprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

公开(公告)号：US20090087405A1

公开(公告)日：2009-04-02

申请号：US12334323

申请日：2008-12-12

申请人： Gerald Juergen ROTH ,  Armin HECKEL ,  Rainer WALTER ,  Frank HILBERG ,  Rudolf HAUPTMANN ,  Martin Friedrich STEFANIC ,  Florian COLBATZKY ,  Steffen ERNST

发明人： Gerald Juergen ROTH ,  Armin HECKEL ,  Rainer WALTER ,  Frank HILBERG ,  Rudolf HAUPTMANN ,  Martin Friedrich STEFANIC ,  Florian COLBATZKY ,  Steffen ERNST

IPC分类号： A61K38/20 ,  A61K31/454 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/517 ,  A61K31/496 ,  A61K31/60 ,  A61K31/5415 ,  A61P37/00 ,  A61K31/56 ,  A61K31/4985 ,  A61K31/675 ,  A61K33/24 ,  A61K38/13 ,  A61K31/4353 ,  A61K38/21

CPC分类号： A61K45/06 ,  A61K31/404 ,  A61K31/454 ,  A61K31/517 ,  A61K2300/00

摘要： The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.

摘要翻译： 本发明涉及一种治疗免疫学疾病或病理状态的方法，该方法使用已知的用作肿瘤学治疗的激酶抑制剂的某些Lck抑制剂，任选与一种或多种其它选自NSAID，类固醇，DMARD，免疫抑制剂， 生物反应调节剂和抗感染剂，包含所述Lck抑制剂与所述其它药物的药物组合物，以及使用Lck抑制剂制备用于治疗免疫学疾病或涉及免疫组分的病理状况的药物组合物。