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1.发明申请Compositions and Methods for Quantitative Histology, Calibration of Images in Fluorescence Microscopy, and ddTUNEL Analyses 审中-公开定量组织学的组成和方法，荧光显微镜中的图像校准和ddTUNEL分析公开(公告)号：US20130157261A1
公开(公告)日：2013-06-20
申请号：US13487058
申请日：2012-06-01
CPC分类号： G01N21/6428 , C12Q1/68 , G01N21/6458 , G01N33/53 , G01N33/567
摘要： Disclosed are compositions and methods for quantitation and calibration of images in fluorescence microscopy. Also provided are tissue phantoms that contain known amount(s) of fluorophore standard(s), as well as components and diagnostic kits containing the same for use in various histological analyses. In certain embodiments, three distinct nucleic-acid based assays provide improvements over conventional TUNEL methods to facilitate precise quantitation of a variety of nucleic acids obtained from a biological sample.
摘要翻译： 公开了用于在荧光显微镜中定量和校准图像的组合物和方法。 还提供了含有已知量的荧光团标准物的组织体模，以及包含其用于各种组织学分析的组分和诊断试剂盒。 在某些实施方案中，三种不同的基于核酸的测定提供了相对于常规TUNEL方法的改进，以促进从生物样品获得的各种核酸的精确定量。
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公开(公告)号：US20140154269A1
公开(公告)日：2014-06-05
申请号：US14114051
申请日：2012-04-26
IPC分类号： A61K9/00
CPC分类号： A61K9/0085 , A61K9/5123 , A61K47/60 , A61K47/6925 , C12N15/87 , C12N2810/859
摘要： In some embodiments, the invention pertains to therapeutic compositions for treating a brain tumor. Such therapeutic compositions generally comprise: (1) a nanovector; (2) an active agent associated with the nanovector with activity against brain tumor cells; and (3) a targeting agent associated with the nanovector with recognition activity for a marker of the brain tumor cells. In some embodiments, the active agent and the targeting agent are non-covalently associated with the nanovector. Additional embodiments of the present invention pertain to methods of treating a brain tumor in a subject (e.g., a human being) by administering the aforementioned therapeutic compositions to the subject. Further embodiments of the present disclosure pertain to methods of formulating therapeutic compositions for treating a brain tumor in a subject in a personalized manner.
摘要翻译： 在一些实施方案中，本发明涉及用于治疗脑肿瘤的治疗组合物。 这样的治疗组合物通常包括：（1）纳维酮; （2）与具有针对脑肿瘤细胞活性的纳米动物相关的活性剂; 和（3）与具有脑肿瘤细胞标志物的识别活性的纳米动物相关的靶向剂。 在一些实施方案中，活性剂和靶向剂与纳米活性剂非共价缔合。 本发明的另外的实施方案涉及通过将上述治疗组合物给予受试者来治疗受试者（例如，人）中的脑肿瘤的方法。 本公开的另外的实施方案涉及以个性化方式配制用于治疗受试者的脑肿瘤的治疗组合物的方法。
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