公开(公告)号：US07928060B2

公开(公告)日：2011-04-19

申请号：US11664750

申请日：2005-10-11

申请人： Mary Erickson ,  Ved Srivastava ,  Sarah McQuaid ,  Andrew Young ,  Richard Pittner ,  Soumitra Ghosh

发明人： Mary Erickson ,  Ved Srivastava ,  Sarah McQuaid ,  Andrew Young ,  Richard Pittner ,  Soumitra Ghosh

IPC分类号： A61K38/22 ,  C07K14/575

CPC分类号： C07K14/575 ,  A61K38/00

摘要： The present invention relates to Amylin Family Polypeptide-6 (AFP-6) analogs, which include derivatives and fragments, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the AFP-6 analogs. The AFP-6 analogs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent conditions such as metabolic and cardiovascular disorders, e.g., obesity, diabetes, metabolic syndrome, myocardial ischemia, and increased cardiovascular risk.

摘要翻译： 本发明涉及淀粉蛋白家族多肽-6（AFP-6）类似物，其包括衍生物和片段，相关核酸，表达构建体，宿主细胞和用于重组生产AFP-6类似物的方法。 本发明的AFP-6类似物包括一个或多个氨基酸序列修饰。 此外，公开了治疗和预防诸如代谢和心血管疾病如肥胖症，糖尿病，代谢综合征，心肌缺血和增加的心血管风险的病症的方法和组合物。

公开(公告)号：US20060135747A1

公开(公告)日：2006-06-22

申请号：US11301744

申请日：2005-12-12

申请人： Odile Levy ,  Carolyn Jodka ,  Soumitra Ghosh ,  David Parkes ,  Richard Pittner ,  Lawrence D'Souza ,  John Ahn ,  Kathryn Prickett ,  Jonathan Roth ,  Sean Adams

发明人： Odile Levy ,  Carolyn Jodka ,  Soumitra Ghosh ,  David Parkes ,  Richard Pittner ,  Lawrence D'Souza ,  John Ahn ,  Kathryn Prickett ,  Jonathan Roth ,  Sean Adams

IPC分类号： A61K38/18 ,  C07K14/475

CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K14/475

摘要： The present invention provides novel Pancreatic Polypeptide Family (“PPF”) polypeptides and methods for their use.

公开(公告)号：US20060094653A1

公开(公告)日：2006-05-04

申请号：US11055098

申请日：2005-02-11

申请人： Odile Levy ,  Carolyn Jodka ,  Soumitra Ghosh ,  David Parkes ,  Richard Pittner ,  Lawrence D'Souza ,  John Ahn ,  Kathryn Prickett

发明人： Odile Levy ,  Carolyn Jodka ,  Soumitra Ghosh ,  David Parkes ,  Richard Pittner ,  Lawrence D'Souza ,  John Ahn ,  Kathryn Prickett

IPC分类号： A61K38/18 ,  C07K14/475

CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K14/475

摘要： The present invention relates to novel Pancreatic Polypeptide Family (“PPF”) polypeptides. The PPF polypeptides of the invention generally include at least two PPF motif, have at least 50% sequence identity to PYY (3-36) over its length and will generally retain, at least in part, a biological activity of a PP, PYY or NPY. Preferred PPF polypeptides of the invention are those having a potency in one of the assays described herein (preferably food intake, gastric emptying, pancreatic secretion, or weight reduction assays) which is greater than the potency of PP, NPY, PYY, or PYY(3-36) in that same assay. In one aspect, the PPF polypeptides of the invention include novel PYY analog polypeptides. In another aspect, the PPF polypeptides of the invention include PPF chimeric polypeptides including a fragment of a PP family polypeptide linked to a second PP family polypeptide, wherein each of the first and second fragments includes a PPF motif. Methods of using the PPF polypeptides of the invention, and pharmaceutical compositions including the PPF polypeptides of the invention are also disclosed.

公开(公告)号：US20100004166A1

公开(公告)日：2010-01-07

申请号：US12294235

申请日：2007-03-23

申请人： Richard Pittner ,  Andrew Young

发明人： Richard Pittner ,  Andrew Young

IPC分类号： A61K38/17 ,  A61P3/00

CPC分类号： A61K38/1709

摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an endothelin or an endothelin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. Pharmaceutical compositions for use in the methods of the invention are also disclosed.

摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独或与影响饱腹感的其它化合物或组合物联合施用有效量的内皮素或内皮素激动剂。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 还公开了用于本发明方法的药物组合物。