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公开(公告)号：US20090280065A1
公开(公告)日：2009-11-12
申请号：US12402408
申请日：2009-03-11
申请人： Mary K. Willian , Martin M. Okun , Rebecca S. Hoffman , Yihua Gu , Lisa Melilli , Kenneth B. Gordon
发明人： Mary K. Willian , Martin M. Okun , Rebecca S. Hoffman , Yihua Gu , Lisa Melilli , Kenneth B. Gordon
IPC分类号： A61B5/00 , A61K39/395 , C07K16/24
CPC分类号： C07K16/241 , A61K2039/505 , A61K2039/54 , A61K2039/545
摘要： The invention provides methods, uses and compositions for the treatment of psoriasis. The invention describes methods and uses for treating psoriasis, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment psoriasis in a subject.
摘要翻译： 本发明提供治疗牛皮癣的方法，用途和组合物。 本发明描述了用于治疗银屑病的方法和用途，其中TNFalpha抑制剂如人TNFα抗体或其抗原结合部分用于治疗受试者的牛皮癣。 还描述了确定受试者中TNFα抑制剂治疗牛皮癣的功效的方法。
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公开(公告)号：US20150050216A1
公开(公告)日：2015-02-19
申请号：US14326061
申请日：2014-07-08
申请人： Mary Kaye Willian , Martin M. Okun , Rebecca S. Hoffman , Yihua Gu , Lisa E. Melilli , Kenneth B. Gordon , Subhashis Banerjee , Lori K. Taylor , Daniel E. Tracey , Elliot K. Chartash , William T. Barchuk , Philip Yan , Anwar Murtaza , Jochen G. Salfeld , Steven A. Fischkoff , George R. Granneman
发明人： Mary Kaye Willian , Martin M. Okun , Rebecca S. Hoffman , Yihua Gu , Lisa E. Melilli , Kenneth B. Gordon , Subhashis Banerjee , Lori K. Taylor , Daniel E. Tracey , Elliot K. Chartash , William T. Barchuk , Philip Yan , Anwar Murtaza , Jochen G. Salfeld , Steven A. Fischkoff , George R. Granneman
IPC分类号： C07K16/24
CPC分类号： C07K16/241 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C07K2317/76 , Y02A50/388
摘要： The invention provides methods, uses and compositions for the treatment of psoriasis. The invention describes methods and uses for treating psoriasis, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment psoriasis in a subject.
摘要翻译： 本发明提供治疗牛皮癣的方法，用途和组合物。 本发明描述了用于治疗牛皮癣的方法和用途，其中使用TNFα抑制剂，例如人TNFα抗体或其抗原结合部分来治疗受试者的牛皮癣。 还描述了确定受试者中TNFα抑制剂治疗牛皮癣的功效的方法。
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公开(公告)号：US09605064B2
公开(公告)日：2017-03-28
申请号：US12859181
申请日：2010-08-18
IPC分类号： A61K39/395 , A61K39/00 , C07K16/24
CPC分类号： C07K16/241 , A61K2039/545 , C07K2317/56 , C07K2317/565
摘要： The invention provides methods and compositions for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis. The invention includes methods for treating a skin disorder associated with detrimental TNFα activity, such as psoriasis, in a subject who has failed or lost response to prior biologic therapy, such as prior administration of etanercept. The invention further provides methods for determining the efficacy of a human TNFα antibody, or antigen-binding portion thereof, for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis.
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4.发明申请USES AND COMPOSITIONS FOR TREATMENT OF PSORIASIS AND CROHN'S DISEASE 审中-公开用于治疗PSORIASIS和CROHN病的用途和组合物公开(公告)号：US20120282262A1
公开(公告)日：2012-11-08
申请号：US13346215
申请日：2012-01-09
申请人： Martin M. Okun , Rebecca S. Hoffman , Thomas C. Harris , Parvez M. Mulani , Jingdong Chao , Talat Ashraf
发明人： Martin M. Okun , Rebecca S. Hoffman , Thomas C. Harris , Parvez M. Mulani , Jingdong Chao , Talat Ashraf
IPC分类号： G06F19/24 , A61P1/00 , A61K39/395
CPC分类号： C07K16/241 , A61K2039/505
摘要： The invention provides methods, uses and compositions for the treatment of psoriasis or Crohn's disease. The invention describes methods and uses for treating psoriasis or Crohn's disease, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. The invention includes methods of improving patient reported outcomes using a human human TNFα antibody, or antigen-binding portion thereof, for the treatment of Crohn's or psoriasis. The invention also provides methods of improving fatigue or depression in patients having Crohns'.
摘要翻译： 本发明提供了用于治疗牛皮癣或克罗恩病的方法，用途和组合物。 本发明描述了用于治疗牛皮癣或克罗恩病的方法和用途，其中使用TNFα抑制剂，例如人TNFα抗体或其抗原结合部分来治疗受试者的牛皮癣。 本发明包括使用人类人TNFα抗体或其抗原结合部分改善患者报告结果的方法，用于治疗克罗恩病或牛皮癣。 本发明还提供了改善患有克罗恩病患者的疲劳或抑郁症的方法。
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公开(公告)号：US20110171227A1
公开(公告)日：2011-07-14
申请号：US12859181
申请日：2010-08-18
IPC分类号： A61K39/395 , A61K39/00 , A61P17/06
CPC分类号： C07K16/241 , A61K2039/545 , C07K2317/56 , C07K2317/565
摘要： The invention provides methods and compositions for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis. The invention includes methods for treating a skin disorder associated with detrimental TNFα activity, such as psoriasis, in a subject who has failed or lost response to prior biologic therapy, such as prior administration of etanercept. The invention further provides methods for determining the efficacy of a human TNFα antibody, or antigen-binding portion thereof, for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis.
摘要翻译： 本发明提供了治疗与有害的TNFα活性相关的皮肤病症如牛皮癣的方法和组合物。 本发明包括治疗与先前生物治疗失败或失去应答的受试者（例如先前给予依那西普）有关的TNFα活性相关的皮肤病症如牛皮癣的方法。 本发明还提供了用于确定人TNFα抗体或其抗原结合部分用于治疗与有害的TNFα活性如牛皮癣相关的皮肤病症的功效的方法。
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公开(公告)号：US20160297879A1
公开(公告)日：2016-10-13
申请号：US14944891
申请日：2015-11-18
申请人： Rebecca S. Hoffman , Eric H. Sasso , Renee J. Perdok , Philip Yan , Mark Weinberg , Philip Mease , Christopher T. Ritchlin , Dafna D. Gladman
发明人： Rebecca S. Hoffman , Eric H. Sasso , Renee J. Perdok , Philip Yan , Mark Weinberg , Philip Mease , Christopher T. Ritchlin , Dafna D. Gladman
CPC分类号： C07K16/241 , A61K49/0004 , A61K2039/505 , C07K2317/21 , C07K2317/76 , Y02A50/388
摘要： The invention provides methods, uses and compositions for the treatment of psoriatic arthritis. The invention describes methods and uses for treating psoriatic arthritis, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to psoriatic arthritis in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment of psoriatic arthritis in a subject.
摘要翻译： 本发明提供了用于治疗牛皮癣关节炎的方法，用途和组合物。 本发明描述了用于治疗牛皮癣关节炎的方法和用途，其中TNFα抑制剂如人TNFα抗体或其抗原结合部分用于受试者的银屑病关节炎。 还描述了确定受试者中TNFα抑制剂治疗银屑病关节炎的功效的方法。
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公开(公告)号：US20130243786A1
公开(公告)日：2013-09-19
申请号：US10623318
申请日：2003-07-18
申请人： Subhashis Banerjee , Lori K. Taylor , Clive E. Spiegler , Daniel Edward Tracey , Elliot K. Chartash , Rebecca S. Hoffman , William T. Barchuk , Philip Yan , Anwar Murtaza , Jochen G. Salfeld , Steven Fischkoff
发明人： Subhashis Banerjee , Lori K. Taylor , Clive E. Spiegler , Daniel Edward Tracey , Elliot K. Chartash , Rebecca S. Hoffman , William T. Barchuk , Philip Yan , Anwar Murtaza , Jochen G. Salfeld , Steven Fischkoff
IPC分类号： A61K39/395 , A61K45/06
CPC分类号： C07K16/241 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/388 , Y02A50/412
摘要： Methods of treating TNFα-related disorders comprising administering TNFα inhibitors, including TNFα antibodies are described.
摘要翻译： 描述了治疗TNFalpha相关病症的方法，包括给予TNFα抑制剂，包括TNFα抗体。
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8.发明授权Multiple-variable dose regimen for treating idiopathic inflammatory bowel disease 有权用于治疗特发性炎性肠病的多变量剂量方案公开(公告)号：US09061005B2
公开(公告)日：2015-06-23
申请号：US13433205
申请日：2012-03-28
IPC分类号： A61K39/395 , C07K16/24 , A61K39/00
CPC分类号： C07K16/241 , A61K9/0019 , A61K31/519 , A61K39/3955 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/388 , Y02A50/412
摘要： Multiple-variable dose methods for treating TNFα-related disorders, including Crohn's disease and psoriasis, comprising administering TNFα inhibitors, including TNFα antibodies, are described. Multiple-variable dose methods include administration of a TNF-inhibitor in an induction or loading phase followed by administration of the agent in a maintenance or treatment phase, wherein the TNF-inhibitor is administered in a higher dosage during the induction phase.
摘要翻译： 描述了用于治疗TNFα相关疾病（包括克罗恩病和牛皮癣）的多变量剂量方法，其包括施用TNFα抑制剂，包括TNFα抗体。 多变量剂量方法包括在诱导或加载阶段施用TNF-抑制剂，随后在维持或治疗阶段施用该药物，其中在诱导阶段以较高剂量施用TNF-抑制剂。
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公开(公告)号：US20140248215A1
公开(公告)日：2014-09-04
申请号：US14010172
申请日：2013-08-26
申请人： Rebecca S. Hoffman , Eric H. Sasso , Renee J. Perdok , Philip Yan , Mark Weinberg , Phillip Mease , Christopher T. Ritchlin , Dafna D. Gladman
发明人： Rebecca S. Hoffman , Eric H. Sasso , Renee J. Perdok , Philip Yan , Mark Weinberg , Phillip Mease , Christopher T. Ritchlin , Dafna D. Gladman
CPC分类号： C07K16/241 , A61K49/0004 , A61K2039/505 , C07K2317/21 , C07K2317/76 , Y02A50/388
摘要： The invention provides methods, uses and compositions for the treatment of psoriatic arthritis. The invention describes methods and uses for treating psoriatic arthritis, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to psoriatic arthritis in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment of psoriatic arthritis in a subject.
摘要翻译： 本发明提供了用于治疗牛皮癣关节炎的方法，用途和组合物。 本发明描述了用于治疗牛皮癣关节炎的方法和用途，其中TNFα抑制剂如人TNFα抗体或其抗原结合部分用于受试者的银屑病关节炎。 还描述了确定受试者中TNFα抑制剂治疗银屑病关节炎的功效的方法。
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10.发明申请公开(公告)号：US20130243763A1
公开(公告)日：2013-09-19
申请号：US13903525
申请日：2013-05-28
申请人： Subhashis Banerjee , Lori K. Taylor , Clive E. Spiegler , Daniel Edward Tracey , Elliot Keith Chartash , Rebecca S. Hoffman , William T. Barchuk , Philip Yan , Anwar Murtaza , Jochen G. Salfeld , Steven A. Fischkoff
发明人： Subhashis Banerjee , Lori K. Taylor , Clive E. Spiegler , Daniel Edward Tracey , Elliot Keith Chartash , Rebecca S. Hoffman , William T. Barchuk , Philip Yan , Anwar Murtaza , Jochen G. Salfeld , Steven A. Fischkoff
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/388 , Y02A50/412
摘要： Methods of treating TNFα-related disorders comprising administering TNFα inhibitors, including TNFα antibodies are described.
摘要翻译： 描述了治疗TNFalpha相关病症的方法，包括给予TNFα抑制剂，包括TNFα抗体。
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