公开(公告)号：US20110300151A1

公开(公告)日：2011-12-08

申请号：US13153131

申请日：2011-06-03

Applicant: Martin M. OKUN ,  Thomas C. Harris

Inventor： Martin M. OKUN ,  Thomas C. Harris

IPC: A61K39/395 ,  A61P17/00 ,  B65D71/00 ,  A61P29/00

CPC classification number: C07K16/241 ,  A61K9/0019 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/545 ,  A61M5/20 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention provides methods, uses and compositions for the treatment of hidradenitis suppurativa. The invention describes methods and uses for treating hidradenitis suppurativa, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat hidradenitis suppurativa in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treating hidradenitis suppurativa in a subject.

Abstract translation: 本发明提供了用于治疗化脓性黑素瘤的方法，用途和组合物。 本发明描述了用于治疗化脓性败血症的方法和用途，其中TNFα抑制剂如人TNFα抗体或其抗原结合部分用于治疗受试者中的化脓性败血症。 还描述了确定受试者中TNFα抑制剂治疗化脓性败血症的功效的方法。

公开(公告)号：US20150050216A1

公开(公告)日：2015-02-19

申请号：US14326061

申请日：2014-07-08

Applicant: Mary Kaye Willian ,  Martin M. Okun ,  Rebecca S. Hoffman ,  Yihua Gu ,  Lisa E. Melilli ,  Kenneth B. Gordon ,  Subhashis Banerjee ,  Lori K. Taylor ,  Daniel E. Tracey ,  Elliot K. Chartash ,  William T. Barchuk ,  Philip Yan ,  Anwar Murtaza ,  Jochen G. Salfeld ,  Steven A. Fischkoff ,  George R. Granneman

Inventor： Mary Kaye Willian ,  Martin M. Okun ,  Rebecca S. Hoffman ,  Yihua Gu ,  Lisa E. Melilli ,  Kenneth B. Gordon ,  Subhashis Banerjee ,  Lori K. Taylor ,  Daniel E. Tracey ,  Elliot K. Chartash ,  William T. Barchuk ,  Philip Yan ,  Anwar Murtaza ,  Jochen G. Salfeld ,  Steven A. Fischkoff ,  George R. Granneman

IPC: C07K16/24

CPC classification number: C07K16/241 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/76 ,  Y02A50/388

Abstract: The invention provides methods, uses and compositions for the treatment of psoriasis. The invention describes methods and uses for treating psoriasis, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment psoriasis in a subject.

Abstract translation: 本发明提供治疗牛皮癣的方法，用途和组合物。 本发明描述了用于治疗牛皮癣的方法和用途，其中使用TNFα抑制剂，例如人TNFα抗体或其抗原结合部分来治疗受试者的牛皮癣。 还描述了确定受试者中TNFα抑制剂治疗牛皮癣的功效的方法。

公开(公告)号：US08747854B2

公开(公告)日：2014-06-10

申请号：US13153131

申请日：2011-06-03

Applicant: Martin M. Okun ,  Thomas C. Harris

Inventor： Martin M. Okun ,  Thomas C. Harris

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K16/24

CPC classification number: C07K16/241 ,  A61K9/0019 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/545 ,  A61M5/20 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention provides methods, uses and compositions for the treatment of hidradenitis suppurativa. The invention describes methods and uses for treating hidradenitis suppurativa, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat hidradenitis suppurativa in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treating hidradenitis suppurativa in a subject.

Abstract translation: 本发明提供了用于治疗化脓性黑素瘤的方法，用途和组合物。 本发明描述了用于治疗化脓性败血症的方法和用途，其中TNFα抑制剂如人TNFα抗体或其抗原结合部分用于治疗受试者中的化脓性败血症。 还描述了确定受试者中TNFα抑制剂治疗化脓性败血症的功效的方法。

公开(公告)号：US08557239B2

公开(公告)日：2013-10-15

申请号：US12881902

申请日：2010-09-14

Applicant: Joaquin Mario Valdes ,  Elliot K. Chartash ,  William T. Barchuk ,  Susan K. Paulson ,  Kenneth B. Gordon ,  Walid M. Awni ,  Yanjun Bao ,  William G. Glass ,  Yihua Gu ,  Tom C. Harris ,  Martin Kaul ,  Parvez M. Mulani ,  Peter Noertersheuser ,  Martin M. Okun

Inventor： Joaquin Mario Valdes ,  Elliot K. Chartash ,  William T. Barchuk ,  Susan K. Paulson ,  Kenneth B. Gordon ,  Walid M. Awni ,  Yanjun Bao ,  William G. Glass ,  Yihua Gu ,  Tom C. Harris ,  Martin Kaul ,  Parvez M. Mulani ,  Peter Noertersheuser ,  Martin M. Okun

IPC: A61K39/395

CPC classification number: C07K16/244 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/76

Abstract: The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.

Abstract translation: 本发明提供了通过向受试者施用能够结合IL-12和/或IL-23的p40亚基的抗体来治疗受试者的牛皮癣的方法。

公开(公告)号：US20120282262A1

公开(公告)日：2012-11-08

申请号：US13346215

申请日：2012-01-09

Applicant: Martin M. Okun ,  Rebecca S. Hoffman ,  Thomas C. Harris ,  Parvez M. Mulani ,  Jingdong Chao ,  Talat Ashraf

Inventor： Martin M. Okun ,  Rebecca S. Hoffman ,  Thomas C. Harris ,  Parvez M. Mulani ,  Jingdong Chao ,  Talat Ashraf

IPC: G06F19/24 ,  A61P1/00 ,  A61K39/395

CPC classification number: C07K16/241 ,  A61K2039/505

Abstract: The invention provides methods, uses and compositions for the treatment of psoriasis or Crohn's disease. The invention describes methods and uses for treating psoriasis or Crohn's disease, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. The invention includes methods of improving patient reported outcomes using a human human TNFα antibody, or antigen-binding portion thereof, for the treatment of Crohn's or psoriasis. The invention also provides methods of improving fatigue or depression in patients having Crohns'.

Abstract translation: 本发明提供了用于治疗牛皮癣或克罗恩病的方法，用途和组合物。 本发明描述了用于治疗牛皮癣或克罗恩病的方法和用途，其中使用TNFα抑制剂，例如人TNFα抗体或其抗原结合部分来治疗受试者的牛皮癣。 本发明包括使用人类人TNFα抗体或其抗原结合部分改善患者报告结果的方法，用于治疗克罗恩病或牛皮癣。 本发明还提供了改善患有克罗恩病患者的疲劳或抑郁症的方法。

公开(公告)号：US20110171227A1

公开(公告)日：2011-07-14

申请号：US12859181

申请日：2010-08-18

Applicant: Martin M. Okun ,  Rebecca S. Hoffman ,  Jonathan Barker

Inventor： Martin M. Okun ,  Rebecca S. Hoffman ,  Jonathan Barker

IPC: A61K39/395 ,  A61K39/00 ,  A61P17/06

CPC classification number: C07K16/241 ,  A61K2039/545 ,  C07K2317/56 ,  C07K2317/565

Abstract: The invention provides methods and compositions for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis. The invention includes methods for treating a skin disorder associated with detrimental TNFα activity, such as psoriasis, in a subject who has failed or lost response to prior biologic therapy, such as prior administration of etanercept. The invention further provides methods for determining the efficacy of a human TNFα antibody, or antigen-binding portion thereof, for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis.

Abstract translation: 本发明提供了治疗与有害的TNFα活性相关的皮肤病症如牛皮癣的方法和组合物。 本发明包括治疗与先前生物治疗失败或失去应答的受试者（例如先前给予依那西普）有关的TNFα活性相关的皮肤病症如牛皮癣的方法。 本发明还提供了用于确定人TNFα抗体或其抗原结合部分用于治疗与有害的TNFα活性如牛皮癣相关的皮肤病症的功效的方法。

公开(公告)号：US20090280065A1

公开(公告)日：2009-11-12

申请号：US12402408

申请日：2009-03-11

Applicant: Mary K. Willian ,  Martin M. Okun ,  Rebecca S. Hoffman ,  Yihua Gu ,  Lisa Melilli ,  Kenneth B. Gordon

Inventor： Mary K. Willian ,  Martin M. Okun ,  Rebecca S. Hoffman ,  Yihua Gu ,  Lisa Melilli ,  Kenneth B. Gordon

IPC: A61B5/00 ,  A61K39/395 ,  C07K16/24

CPC classification number: C07K16/241 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545

Abstract: The invention provides methods, uses and compositions for the treatment of psoriasis. The invention describes methods and uses for treating psoriasis, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment psoriasis in a subject.

Abstract translation: 本发明提供治疗牛皮癣的方法，用途和组合物。 本发明描述了用于治疗银屑病的方法和用途，其中TNFalpha抑制剂如人TNFα抗体或其抗原结合部分用于治疗受试者的牛皮癣。 还描述了确定受试者中TNFα抑制剂治疗牛皮癣的功效的方法。

公开(公告)号：US20100003243A1

公开(公告)日：2010-01-07

申请号：US12352503

申请日：2009-01-12

Applicant: MARTIN M. OKUN ,  REBECCA S. HOFFMAN ,  THOMAS C. HARRIS ,  PARVEZ M. MULANI ,  JINGDONG CHAO ,  Talat Ashraf

Inventor： MARTIN M. OKUN ,  REBECCA S. HOFFMAN ,  THOMAS C. HARRIS ,  PARVEZ M. MULANI ,  JINGDONG CHAO ,  Talat Ashraf

IPC: A61K39/395 ,  G06F19/00 ,  G06F17/18

CPC classification number: C07K16/241 ,  A61K2039/505

Abstract: The invention provides methods, uses and compositions for the treatment of psoriasis or Crohn's disease. The invention describes methods and uses for treating psoriasis or Crohn's disease, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. The invention includes methods of improving patient reported outcomes using a human TNFα antibody, or antigen-binding portion thereof, for the treatment of Crohn's or psoriasis. The invention also provides methods of improving fatigue or depression in patients having Crohns'.

Abstract translation: 本发明提供了用于治疗牛皮癣或克罗恩病的方法，用途和组合物。 本发明描述了用于治疗牛皮癣或克罗恩病的方法和用途，其中TNFalpha抑制剂如人TNFα抗体或其抗原结合部分用于治疗受试者的牛皮癣。 本发明包括使用人TNFα抗体或其抗原结合部分改善患者报告结果的方法，用于治疗克罗恩病或牛皮癣。 本发明还提供了改善患有克罗恩病患者的疲劳或抑郁症的方法。

公开(公告)号：US09605064B2

公开(公告)日：2017-03-28

申请号：US12859181

申请日：2010-08-18

Applicant: Martin M. Okun ,  Rebecca S. Hoffman ,  Jonathan Barker

Inventor： Martin M. Okun ,  Rebecca S. Hoffman ,  Jonathan Barker

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/24

CPC classification number: C07K16/241 ,  A61K2039/545 ,  C07K2317/56 ,  C07K2317/565

Abstract: The invention provides methods and compositions for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis. The invention includes methods for treating a skin disorder associated with detrimental TNFα activity, such as psoriasis, in a subject who has failed or lost response to prior biologic therapy, such as prior administration of etanercept. The invention further provides methods for determining the efficacy of a human TNFα antibody, or antigen-binding portion thereof, for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis.

公开(公告)号：US20140079714A1

公开(公告)日：2014-03-20

申请号：US14023590

申请日：2013-09-11

Applicant: Joaquin Mario Valdes ,  Elliot K. Chartash ,  William T. Barchuk ,  Susan K. Paulson ,  Kenneth B. Gordon ,  Walid M. Awni ,  Yanjun Bao ,  William G. Glass ,  Yihua Gu ,  Thomas C. Harris ,  Martin Kaul ,  Parvez M. Mulani ,  Peter A. Noertersheuser ,  Martin M. Okun

Inventor： Joaquin Mario Valdes ,  Elliot K. Chartash ,  William T. Barchuk ,  Susan K. Paulson ,  Kenneth B. Gordon ,  Walid M. Awni ,  Yanjun Bao ,  William G. Glass ,  Yihua Gu ,  Thomas C. Harris ,  Martin Kaul ,  Parvez M. Mulani ,  Peter A. Noertersheuser ,  Martin M. Okun

IPC: C07K16/24

CPC classification number: C07K16/244 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/76

Abstract: The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.

Abstract translation: 本发明提供了通过向受试者施用能够结合IL-12和/或IL-23的p40亚基的抗体来治疗受试者的牛皮癣的方法。