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    Controlled Release Solid Preparation
    1.
    发明申请
    Controlled Release Solid Preparation 有权
    控释固体制剂

    公开(公告)号：US20090269401A1

    公开(公告)日：2009-10-29

    申请号：US12084824

    申请日：2006-11-10

    申请人： Masaaki Endo ,  Kazuhiro Obae ,  Ichirou Ibuki ,  Yoshihito Yaginuma

    发明人： Masaaki Endo ,  Kazuhiro Obae ,  Ichirou Ibuki ,  Yoshihito Yaginuma

    IPC分类号： A61K47/26 ,  A61K9/20

    CPC分类号： A61K9/2086 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/209

    摘要： Disclosed is a solid preparation which comprises at least one active ingredient and at least one dissolution-controlling base substance and can be formed by compression molding, wherein the dissolution-controlling base substance contains 5.0 to 99.9% by weight (inclusive) of a modified starch having a moisture retaining capacity of 400% or more and a gel indentation load of 200 g or more, containing a water-soluble ingredient in an amount of 40 to 95% by weight, having particles passing through a 75 μm-mesh sieve in the proportion of 90% by weight or more and particles passing through a 32 μm-mesh sieve in the proportion of 20% by weight or more, and having an average particle diameter of not smaller than 20 μm and smaller than 50 μm.

    摘要翻译： 公开了一种固体制剂，其包含至少一种活性成分和至少一种溶解控制基质，并且可以通过压缩成型形成，其中所述溶解控制基质含有5.0-99.9重量％（包括）改性淀粉 具有400％以上的保湿能力和200g以上的凝胶压痕负荷，含有40〜95重量％的水溶性成分，其中通过75μm筛网的颗粒在 比例为90重量％以上，颗粒通过32μm筛网的比例为20重量％以上，平均粒径为20μm以上且小于50μm的粒子。

    Controlled release solid preparation
    2.
    发明授权
    Controlled release solid preparation 有权
    控释固体制剂

    公开(公告)号：US09029427B2

    公开(公告)日：2015-05-12

    申请号：US12084824

    申请日：2006-11-10

    申请人： Masaaki Endo ,  Kazuhiro Obae ,  Ichirou Ibuki ,  Yoshihito Yaginuma

    发明人： Masaaki Endo ,  Kazuhiro Obae ,  Ichirou Ibuki ,  Yoshihito Yaginuma

    IPC分类号： A61K47/36 ,  A61K9/20 ,  A61K9/24 ,  A01N25/10

    CPC分类号： A61K9/2086 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/209

    摘要： Disclosed is a solid preparation which comprises at least one active ingredient and at least one dissolution-controlling base substance and can be formed by compression molding, wherein the dissolution-controlling base substance contains 5.0 to 99.9% by weight (inclusive) of a modified starch having a moisture retaining capacity of 400% or more and a gel indentation load of 200 g or more, containing a water-soluble ingredient in an amount of 40 to 95% by weight, having particles passing through a 75 μm-mesh sieve in the proportion of 90% by weight or more and particles passing through a 32 μm-mesh sieve in the proportion of 20% by weight or more, and having an average particle diameter of not smaller than 20 μm and smaller than 50 μm.

    摘要翻译： 公开了一种固体制剂，其包含至少一种活性成分和至少一种溶解控制基质，并且可以通过压缩成型形成，其中所述溶解控制基质含有5.0-99.9重量％（包括）改性淀粉 具有400％以上的保湿能力和200g以上的凝胶压痕负荷，含有40〜95重量％的水溶性成分，其中通过75μm筛网的颗粒在 比例为90重量％以上，颗粒通过32μm筛网的比例为20重量％以上，平均粒径为20μm以上且小于50μm的比例。