利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.046 秒)

    Pyrimidine compound and anti-rotavirus composition
    1.
    发明授权
    Pyrimidine compound and anti-rotavirus composition 失效
    嘧啶化合物和抗轮状病毒组合物

    公开(公告)号：US6080750A

    公开(公告)日：2000-06-27

    申请号：US852118

    申请日：1997-05-06

    申请人： Masakatsu Hisaki ,  Yoichiro Ohta ,  Kenji Kawanishi ,  Yasuko Ichigobara ,  Fuzuki Iwakura ,  Masanobu Azuma ,  Tatsuo Suzutani ,  Manabu Node ,  Kiyoharu Nishide

    发明人： Masakatsu Hisaki ,  Yoichiro Ohta ,  Kenji Kawanishi ,  Yasuko Ichigobara ,  Fuzuki Iwakura ,  Masanobu Azuma ,  Tatsuo Suzutani ,  Manabu Node ,  Kiyoharu Nishide

    IPC分类号： C07D239/47 ,  A61K31/505 ,  A61P31/12 ,  C07D239/48 ,  C07D239/50 ,  C07D239/52 ,  C07D405/12

    CPC分类号： C07D239/48 ,  C07D239/50

    摘要： A pyrimidine compound of the formula [I] ##STR1## wherein R1 is H, C.sub.1 -C.sub.4 lower alkyl, halogen atom, --OH, C.sub.1 -C.sub.4 lower alkoxy, C.sub.1 -C.sub.6 hydroxy(lower)alkoxy or --NH.sub.2 ; R2 is H, --NH.sub.2 or --NHCOCH.sub.3 ; R3 is --NR5(CH.sub.2)i--CH.sub.2 OH; R4 is H, halogen atom, --NH.sub.2, --CN, --CHO, --CH.sub.2 OH, --COOH, --CH.sub.2 NH.sub.2, --CONH.sub.2 or --CH.dbd.N--A wherein A is --OH, C.sub.1 -C.sub.4 lower alkyl or C.sub.1 -C.sub.4 lower alkoxy; R5 is H or C.sub.1 -C.sub.4 lower alkyl; and i is an integer of 1 to 4, and an anti-rotavirus agent comprising, as an active ingredient, a compound of the formula [I] wherein R3 is a group selected from the following: ##STR2## The novel pyrimidine compound of the present invention and related derivatives thereof have superior anti-rotavirus action and are useful for the prophylaxis and treatment of rotaviral diseases.

    摘要翻译： 式[I]的嘧啶化合物，其中R 1是H，C 1 -C 4低级烷基，卤素原子，-OH，C 1 -C 4低级烷氧基，C 1 -C 6羟基（低级）烷氧基或-NH 2; R2是H，-NH2或-NHCOCH3; R3是-NR5（CH2）i-CH2OH; R4是H，卤素原子，-NH2，-CN，-CHO，-CH2OH，-COOH，-CH2NH2，-CONH2或-CH = N-A，其中A是-OH，C1-C4低级烷基或C1-C4低级烷氧基; R5是H或C1-C4低级烷基; i为1〜4的整数，作为活性成分的抗轮状病毒药，其中，R 3为选自下述的基团的式[I]的化合物：本发明的新型嘧啶化合物和 其相关衍生物具有优异的抗轮状病毒作用，并且可用于预防和治疗轮状病毒疾病。

    Process for the preparation of a trifluorovinylsilane, and fluorine-containing polymer and process for its preparation
    3.
    发明授权
    Process for the preparation of a trifluorovinylsilane, and fluorine-containing polymer and process for its preparation 失效
    制备三氟乙烯基硅烷和含氟聚合物的方法及其制备方法

    公开(公告)号：US4481366A

    公开(公告)日：1984-11-06

    申请号：US572247

    申请日：1984-01-20

    申请人： Tamejiro Hiyama ,  Kiyoharu Nishide

    发明人： Tamejiro Hiyama ,  Kiyoharu Nishide

    IPC分类号： C07F7/08 ,  C08F30/08 ,  C07C7/08

    CPC分类号： C07F7/0827 ,  C08F30/08

    摘要： A process for preparing a trifluorovinylsilane represented by the general formula:(CF.sub.2 .dbd.CF).sub.n SiR.sub.4-n (I)where each R independently represents an alkyl group, an aryl group or an aralkyl group, and n is an integer of 1 to 4, which comprises the reaction of chlorotrifluoroethylene with a chlorosilane represented by the general formula:Cl.sub.n SiR.sub.4-n (II)where R and n are as defined above, in the presence of an alkyllithium. Also disclosed is a fluorine-containing polymer represented by the general formula: ##STR1## where each of x and m is an integer other than O, y is an integer including O, and each of R.sup.1, R.sup.2 and R.sup.3 is a lower alkyl group, an aryl group or an aralkyl group, which is prepared by polymerization of a trifluorovinyl silane (I) with active fluoride-ion generating catalyst.

    摘要翻译： 一种制备由以下通式表示的三氟乙烯基硅烷的方法：（CF 2 = CF）n SiR 4-n（I）其中每个R独立地表示烷基，芳基或芳烷基，n是1至4的整数， 其包括在三烷基锂存在下氯三氟乙烯与由以下通式表示的氯代硅烷的反应：其中R和n如上所定义。 还公开了由以下通式表示的含氟聚合物：其中x和m各自为O以外的整数，y为包括O的整数，R 1，R 2和R 3各自为 低级烷基，芳基或芳烷基，其通过三氟乙烯基硅烷（I）与活性氟离子产生催化剂的聚合制备。