公开(公告)号：US5204087A

公开(公告)日：1993-04-20

申请号：US806791

申请日：1991-12-12

申请人： Masami Moroi ,  Kimie Ominato ,  Toshio Yokoyama ,  Akira Iwasa

发明人： Masami Moroi ,  Kimie Ominato ,  Toshio Yokoyama ,  Akira Iwasa

IPC分类号： A61K9/00 ,  A61K9/46

CPC分类号： A61K9/0056 ,  A61K9/0007

摘要： A composition for foaming preparation comprising (a) an organic acid of which the crystal surface is coated with a sugar and (b) a carbonate is disclosed. In the composition, an organic acid is completely shut off from a carbonate by a sugar coating so that the acid does not react with the carbonate over a prolonged storage time. When the composition is put into mouth, the sugar which covers the acid is readily dissolved, allowing the acid and the carbonate to react and to generate carbon oxide gas. An excellent foaming calcium preparation can be produced by using calcium carbonate as the carbonate or by adding other salt of calcium to the composition. Such a calcium preparation gives a good taste and favorable feeling upon administration. It is especially suitable for regular administration of calcium over an extended period of time.

摘要翻译： 公开了一种用于发泡制备的组合物，其包含（a）晶体表面被糖包覆的有机酸和（b）碳酸酯。 在组合物中，有机酸通过糖衣完全与碳酸盐隔绝，使得酸不会在延长的储存时间内与碳酸盐反应。 当组合物放入口中时，覆盖酸的糖容易溶解，使酸和碳酸酯反应并产生碳氧化物气体。 可以通过使用碳酸钙作为碳酸盐或通过向组合物中加入钙的其它盐来制备出色的起泡钙制剂。 这样的钙制剂在施用时具有良好的味道和良好的感觉。 特别适合于长时间钙的定期给药。