公开(公告)号：US08039514B2

公开(公告)日：2011-10-18

申请号：US12476585

申请日：2009-06-02

申请人： Masami Ogawa ,  Kazuhiko Kitagawa ,  Hiromitsu Shirahashi ,  Satomi Kuribayashi

发明人： Masami Ogawa ,  Kazuhiko Kitagawa ,  Hiromitsu Shirahashi ,  Satomi Kuribayashi

IPC分类号： A61K31/18 ,  A01N41/12 ,  C07D213/00

CPC分类号： C07D333/34 ,  C07C311/13 ,  C07C311/18 ,  C07C311/29 ,  C07C311/41 ,  C07C311/46 ,  C07C323/32 ,  C07C323/52 ,  C07C323/67 ,  C07C2602/08 ,  C07D213/36 ,  C07D213/55 ,  C07D213/79 ,  C07D213/83 ,  C07D333/24 ,  C07D409/12

摘要： The sulfoneamide compounds having the following Formula (1), which can be used as an effective component of a CaSR antagonizing agent useful for prophylaxis and/or treatment of bone disorders including osteoporosis and etc., are provided. The compounds have an excellent activity of promoting PTH secretion. In addition, the compounds are useful as an effective component of a medicament for the prophylaxis and/or treatment of bone disorders such as osteoporosis, bone fracture, hypoparathyroidism and the like.

摘要翻译： 提供了可用作可用于预防和/或治疗包括骨质疏松症等骨病症的CaSR拮抗剂的有效成分的具有下式（1）的磺酰胺化合物。 该化合物具有优异的促进PTH分泌的活性。 此外，这些化合物可用作预防和/或治疗骨质疏松症，骨折，甲状旁腺功能减退等骨病症的药物的有效成分。

公开(公告)号：US5395466A

公开(公告)日：1995-03-07

申请号：US86847

申请日：1993-07-07

申请人： Kouichi Tukagoshi ,  Takuya Kitamura ,  Kiyoto Fujii ,  Kazuo Higuchi ,  Shinji Imai ,  Kazuhiko Kitagawa

发明人： Kouichi Tukagoshi ,  Takuya Kitamura ,  Kiyoto Fujii ,  Kazuo Higuchi ,  Shinji Imai ,  Kazuhiko Kitagawa

IPC分类号： B42C9/00 ,  B32B3/04

CPC分类号： B42C9/0068 ,  Y10T156/1028 ,  Y10T156/1034 ,  Y10T156/1983

摘要： A back pasting apparatus which uses a back pasting adhesive tape and is intended to make the apparatus compact and to improve back pasting quality. A guide rail (16) movable back and forth with respect to a frame (14) is provided. A paper table (15) arranged opposite to the guide rail (16) is biased by a spring or the like in the direction of the guide rail (16). The guide rail (16) and a clamp (22) are driven by a drive mechanism. First, a back pasting adhesive tape (30) is fed by a tape feeder into the guide groove (19) of the guide rail (16). As the clamp (22) lowers, the cover of papers (17) is pressed against the adhesive tape (30). The guide rail (16) is moved down along the grooves (20, 20) before being moved forward. As a result, only the paper table (15) is pressed down and moved back so that the adhesive tape (30) is pressed against the back and back cover of the papers (17).

摘要翻译： 背面粘贴装置，其使用背面粘贴胶带，旨在使装置紧凑并提高背胶质量。 提供了相对于框架（14）来回移动的导轨（16）。 与导轨（16）相对布置的纸台（15）通过弹簧等沿导轨（16）的方向偏置。 导轨（16）和夹具（22）由驱动机构驱动。 首先，将背面胶粘带（30）由带状进料器供给到导轨（16）的引导槽（19）中。 当夹具（22）降低时，纸张（17）的盖被压靠在胶带（30）上。 在向前移动之前，导轨（16）沿凹槽（20,20）向下移动。 结果，只有纸台（15）被压下并向后移动，使得胶带（30）被压靠在纸张（17）的后盖和后盖上。