公开(公告)号：US4560703A

公开(公告)日：1985-12-24

申请号：US535258

申请日：1983-09-23

申请人： Masanori Fukushima ,  Osamu Hirai ,  Toshitaka Manda ,  Hiroyuki Kikuchi ,  Yasumasa Tsukitani ,  Iwao Shimizu ,  Yasuji Yamada

发明人： Masanori Fukushima ,  Osamu Hirai ,  Toshitaka Manda ,  Hiroyuki Kikuchi ,  Yasumasa Tsukitani ,  Iwao Shimizu ,  Yasuji Yamada

IPC分类号： C07C405/00 ,  C07C69/732 ,  A61K31/215 ,  C07C69/738

CPC分类号： C07C405/00

摘要： Novel clavulone derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 combine together to form a keto group or either one of R.sup.1 and R.sup.2 is hydrogen atom and another one of them is hydroxy or acetoxy group, R.sup.3 and R.sup.4 are the same or different and are each hydrogen atom or acetoxy group, n is 0 or 1, provided that when the C--C bond between 8 and 12 positions is double bond, n is 0, a, b, c, d and e are each an integer of 1 or 2, and the dotted line means that the C--C bond is a single bond or double bond, or a salt thereof, which have excellent anti-inflammatory activity and anti-tumor activity and hence are useful as an anti-inflammatory agent or anti-tumor agent.

摘要翻译： 下式的新型克拉维酮衍生物：其中R 1和R 2结合在一起形成酮基或R 1和R 2中的任一个是氢原子，另一个是羟基或乙酰氧基，R 3和R 4是 相同或不同，各自为氢原子或乙酰氧基，n为0或1，条件是当8和12位之间的CC键为双键时，n为0，a，b，c，d和e各自为整数 为1或2，虚线表示CC键为单键或双键或其盐，其具有优异的抗炎活性和抗肿瘤活性，因此可用作抗炎剂或 抗肿瘤剂。