公开(公告)号：US20050130934A1

公开(公告)日：2005-06-16

申请号：US11049423

申请日：2005-02-02

申请人： Masato Nagaoka ,  Hideyuki Shibata ,  Itsuko Takagi ,  Shusuke Hashimoto

发明人： Masato Nagaoka ,  Hideyuki Shibata ,  Itsuko Takagi ,  Shusuke Hashimoto

IPC分类号： A61K31/731 ,  A61K31/737 ,  C08B37/00

CPC分类号： A61K31/702 ,  A61K31/731 ,  A61K31/737

摘要： An antibacterial agent showing a high affinity for Helicobactor pyroli and having an antibacterial effect specific to H. Pyroli. The agent has a chemical structure wherein an antibacterial substance is bonded to a sulfated polysaccharide or an oligosaccharide prepared by partial decomposition of the sulfated polysaccharide. Preferable embodiments are those having the chemical structure represented by Y—OCH(AH2NHR)n or Y—BH2NHR, wherein Y represents a sulfated polysaccharide or an oligosaccharide prepared by partial decomposition of the sulfated polysaccharide; A a carbon derived from aldehyde group occurring through the reduction of the reduced end sugar of Y and subsequent oxidation of the resulting product with an oxidant; B a carbon derived from the aldehyde group at the reduced end sugar of Y; R an antibacterial substance with a primary amino group or with an amino group introduced therein or represents an antibacterial substance derivative prepared by bonding an antibacterial substance through a spacer to the carbon A or the carbon B; and n=1 or 2.

摘要翻译： 对Helicobactor pyroli具有高亲和力并具有对H. Pyroli特异性的抗菌作用的抗菌剂。 该药剂具有抗菌物质与通过硫酸化多糖的部分分解制备的硫酸化多糖或寡糖结合的化学结构。 优选的实施方案是具有由Y-OCH（AHN 2 NHR）n或Y-BH 2 NHR表示的化学结构的那些，其中Y表示 通过硫酸化多糖的部分分解制备的硫酸化多糖或寡糖; 衍生自醛基的碳通过还原末端糖的Y而发生，随后用氧化剂氧化所得产物; B是衍生自Y的还原末端糖的醛基的碳; R是具有伯氨基或在其中引入氨基的抗菌物质，或代表通过间隔剂将抗菌物质与碳A或碳B结合而制备的抗菌物质衍生物; n = 1或2。

公开(公告)号：US07498317B2

公开(公告)日：2009-03-03

申请号：US11049423

申请日：2005-02-02

申请人： Masato Nagaoka ,  Hideyuki Shibata ,  Itsuko Takagi ,  Shusuke Hashimoto

发明人： Masato Nagaoka ,  Hideyuki Shibata ,  Itsuko Takagi ,  Shusuke Hashimoto

IPC分类号： A61K31/731 ,  A61K31/737

CPC分类号： A61K31/702 ,  A61K31/731 ,  A61K31/737

摘要： An antibacterial agent showing a high affinity for Helicobactor pyroli and having an antibacterial effect specific to H. Pyroli. The agent has a chemical structure wherein an antibacterial substance is bonded to a sulfated polysaccharide or an oligosaccharide prepared by partial decomposition of the sulfated polysaccharide. Preferable embodiments are those having the chemical structure represented by Y—OCH(AH2NHR)n or Y—BH2NHR, wherein Y represents a sulfated polysaccharide or an oligosaccharide prepared by partial decomposition of the sulfated polysaccharide; A a carbon derived from aldehyde group occurring through the reduction of the reduced end sugar of Y and subsequent oxidation of the resulting product with an oxidant; B a carbon derived from the aldehyde group at the reduced end sugar of Y; R an antibacterial substance with a primary amino group or with an amino group introduced therein or represents an antibacterial substance derivative prepared by bonding an antibacterial substance through a spacer to the carbon A or the carbon B; and n=1 or 2.

摘要翻译： 对Helicobactor pyroli具有高亲和力并具有对H. Pyroli特异性的抗菌作用的抗菌剂。 该药剂具有抗菌物质与通过硫酸化多糖的部分分解制备的硫酸化多糖或寡糖结合的化学结构。 优选的实施方案是具有由Y-OCH（AH2NHR）n或Y-BH2NHR表示的化学结构的那些，其中Y表示硫酸化多糖或通过硫酸化多糖的部分分解制备的寡糖; 衍生自醛基的碳通过还原末端糖的Y而发生，随后用氧化剂氧化所得产物; B是衍生自Y的还原末端糖的醛基的碳; R是具有伯氨基或在其中引入氨基的抗菌物质，或代表通过间隔剂将抗菌物质与碳A或碳B结合而制备的抗菌物质衍生物; n = 1或2。