公开(公告)号：US20140088039A1

公开(公告)日：2014-03-27

申请号：US14116459

申请日：2012-06-22

申请人： Koji Inagaki ,  Toshihiro Ogawa ,  Yoshihide Horibe ,  Atsuyoshi Dota ,  Takashi Nagano ,  Masatsugu Nakamura ,  Yuichiro Nakada

发明人： Koji Inagaki ,  Toshihiro Ogawa ,  Yoshihide Horibe ,  Atsuyoshi Dota ,  Takashi Nagano ,  Masatsugu Nakamura ,  Yuichiro Nakada

IPC分类号： A61K47/08 ,  A61K47/18 ,  A61K9/00 ,  A61K31/728

CPC分类号： A61K47/08 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/728 ,  A61K47/10 ,  A61K47/186 ,  A61K47/36

摘要： An aqueous ophthalmic solution containing hyaluronic acid or a salt thereof at a concentration from 0.03 to 0.5% (w/v) and propylene glycol at a concentration from 0.1 to 1.0% (w/v) comprises as a sole preservative, benzalkonium chloride at a concentration from 0.001 to 0.002% (w/v) and comprises an ionic tonicity agent at such a concentration that an osmotic pressure ratio of the ophthalmic solution becomes from 0.9 to 1.1.

摘要翻译： 含有浓度为0.03至0.5％（w / v）的透明质酸或其盐和浓度为0.1至1.0％（w / v）的丙二醇的眼用水溶液包含作为唯一防腐剂，苯扎氯铵 浓度从0.001至0.002％（w / v），并且包含浓度使得眼用溶液的渗透压比为0.9至1.1的浓度的离子张力剂。

公开(公告)号：US20130172287A1

公开(公告)日：2013-07-04

申请号：US13821717

申请日：2011-09-09

申请人： Yuko Shichijo ,  Atsuyoshi Dota ,  Takashi Nagano ,  Masatsugu Nakamura ,  Asuka Sakamoto

发明人： Yuko Shichijo ,  Atsuyoshi Dota ,  Takashi Nagano ,  Masatsugu Nakamura ,  Asuka Sakamoto

IPC分类号： A61K31/728 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076

CPC分类号： A61K31/728 ,  A61K31/675 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K45/06 ,  A61K2300/00

摘要： An agent for treatment of dry eye comprising a combination of a P2Y2 receptor agonist at a therapeutically effective concentration and hyaluronic acid or a salt thereof at a therapeutically effective concentration, which agent has a dosage form of an ophthalmic agent, can promote the secretion of tear remarkably and can improve corneal epithelial disorders remarkably, and is therefore expected to be a novel agent for treatment of dry eye.

摘要翻译： 一种用于治疗干眼症的药物，其包括治疗有效浓度的P2Y2受体激动剂和透明质酸或其盐的治疗有效浓度的组合，该药剂具有眼用剂型，可促进泪液的分泌 明显地可以改善角膜上皮疾病，因此预期它们是用于治疗干眼症的新型药剂。

公开(公告)号：US20120165273A1

公开(公告)日：2012-06-28

申请号：US13394194

申请日：2010-09-24

申请人： Takahiro Nakamura ,  Yuichiro Nakada ,  Takashi Nagano ,  Masatsugu Nakamura

发明人： Takahiro Nakamura ,  Yuichiro Nakada ,  Takashi Nagano ,  Masatsugu Nakamura

IPC分类号： A61K38/07 ,  A61P27/02

CPC分类号： A61K38/07 ,  A61K9/0048 ,  C07K5/1013 ,  C07K5/1016 ,  A61K2300/00

摘要： An eyedrop containing a peptide having an amino acid sequence represented by Ser-Ser-Ser-Arg (“SSSR”), or a pharmacologically acceptable salt thereof; and a peptide having an amino acid sequence represented by Phe-Gly-Leu-Met-NH2 (“FGLM”), or a pharmacologically acceptable salt thereof. The concentration ratio between SSSR or a pharmacologically acceptable salt thereof and FGLM or a pharmacologically acceptable salt thereof is between 1/15 and 1/50. The concentration of SSSR or a pharmacologically acceptable salt thereof is between 0.001% and 0.3% (w/v) and the concentration of FGLM or a pharmacologically acceptable salt thereof is between 0.015% and 1.5% (w/V). The pH of the eye drop is maintained between 2.5 and 6.5.

摘要翻译： 含有具有由Ser-Ser-Ser-Arg（“SSSR”）表示的氨基酸序列的肽或其药理学上可接受的盐的滴眼剂; 和具有由Phe-Gly-Leu-Met-NH 2（“FGLM”）表示的氨基酸序列的肽或其药理学上可接受的盐。 SSSR或其药理学上可接受的盐与FGLM或其药理学上可接受的盐之间的浓度比为1/15至1/50。 SSSR或其药理学上可接受的盐的浓度为0.001％至0.3％（w / v），并且FGLM或其药理学上可接受的盐的浓度为0.015％至1.5％（w / V）。 滴眼液的pH值保持在2.5至6.5之间。

公开(公告)号：US20070077278A1

公开(公告)日：2007-04-05

申请号：US10577970

申请日：2004-11-10

申请人： Yukiko Sugihara ,  Akio Kimura ,  Masatsugu Nakamura ,  Kazuhiro Tanashashi ,  Miho Araki ,  Takashi Taniguchi

发明人： Yukiko Sugihara ,  Akio Kimura ,  Masatsugu Nakamura ,  Kazuhiro Tanashashi ,  Miho Araki ,  Takashi Taniguchi

IPC分类号： A61K31/729

CPC分类号： A61K9/0048 ,  A61K47/36

摘要： An object of the present invention is to provide a composition which is excellent in safety and capable of dispersing uniformly on the mucous tissue when topically administered to mammals, and an ophthalmic solution comprising the composition and capable of stabilizing the tear film and keeping the tear film on the eyeball surface smooth. In a composition comprising a polysaccharide, particularly agar, and water as essential components, an ophthalmic solution comprising the agar-containing composition of which an amount of precipitated agar after performing centrifugal separation at with 40,000 ×g is less than 65 wt % of a total agar content has an excellent tear film stabilizing effect which was proved by a test on changes of corneal surface irregularity. Therefore, the agar-containing ophthalmic solution of the present invention has the effect of stabilizing the tear film on the eyeball surface over a prolonged period of time and is usable as an artificial tear fluid.

摘要翻译： 本发明的目的在于提供一种组合物，其安全性优异，能够均匀地分散在哺乳动物局部施用的粘膜组织上时，还含有该组合物的眼用溶液，能够使泪液膜稳定并保持泪液膜 在眼球表面光滑。 在包含多糖，特别是琼脂和水作为必要组分的组合物中，包含含有琼脂的组合物的眼用溶液的用量为40,000×g离心分离后的沉淀琼脂的量小于总琼脂的65重量％ 内容物具有优异的泪膜稳定作用，通过对角膜表面不规则变化的测试证明。 因此，本发明的含有琼脂的眼用溶液具有使眼球表面上的泪膜长时间稳定的效果，可用作人工泪液。

公开(公告)号：US20070058199A1

公开(公告)日：2007-03-15

申请号：US11497674

申请日：2006-08-01

申请人： Hiroshi Kawano ,  Masatsugu Nakamura ,  Shinji Imagawa ,  Takashi Kitagawa ,  Masaaki Ohtsuki

发明人： Hiroshi Kawano ,  Masatsugu Nakamura ,  Shinji Imagawa ,  Takashi Kitagawa ,  Masaaki Ohtsuki

IPC分类号： H04N1/40

CPC分类号： G03G15/556 ,  G03G15/0856 ,  G03G15/5041 ,  G03G15/5079 ,  G03G15/553

摘要： A small domain generation section generates a plurality of small domains in a multi-valued image transmitted from an intermediate tone correction section. Each domain is constituted of a plurality of pixels. Counting means counts a signal input value of each pixel. Weighting calculation means corrects each signal input value of the “pixels subjection to toner quantity equivalent value calculation” with reference to the signal input value of the small domain, and reads out a weighting coefficient from the weighting coefficient table based on the modified signal input value. The weighting calculation means multiplies the signal input value by the coefficient so as to convert the signal input value into a toner quantity equivalent value. Accumulating means calculates toner quantity equivalent values for all of the pixels of the multi-valued image. A total toner quantity equivalent value calculation section determines a total toner quantity equivalent value by accumulating all of the toner quantity equivalent values which are individually calculated each time an image is processed. When the total toner quantity equivalent value reaches a predetermined value, conditions for process control is set. On this account, the present invention achieves an image forming apparatus capable of accurate estimation of toner consumption quantity.

摘要翻译： 小域生成部在从中间色调校正部发送的多值图像中生成多个小域。 每个域由多个像素组成。 计数装置计算每个像素的信号输入值。 加权计算装置参考小域的信号输入值来校正“像素对调色剂量等效值计算的像素”的每个信号输入值，并且基于修改的信号输入值从加权系数表读出加权系数 。 加权计算装置将信号输入值乘以系数，以便将信号输入值转换成调色剂量当量值。 累积装置计算多值图像的所有像素的调色剂量等效值。 总调色剂量当量值计算部通过累积每次处理图像时分别计算的所有调色剂量等效值来确定总调色剂量当量值。 当总调色剂量当量值达到预定值时，设定用于处理控制的条件。 因此，本发明实现了能够准确地估计调色剂消耗量的图像形成装置。

公开(公告)号：US07071166B2

公开(公告)日：2006-07-04

申请号：US10344199

申请日：2001-08-10

申请人： Teruo Nishida ,  Katsuhiko Nakata ,  Masatsugu Nakamura

发明人： Teruo Nishida ,  Katsuhiko Nakata ,  Masatsugu Nakamura

IPC分类号： A61K38/00

CPC分类号： A61K38/046 ,  A61K38/30 ,  A61K2300/00

摘要： The present invention provides healing promoters for skin wounds such as rupture, abrasion, surgical incision, skin ulcer and burn. Coexistence of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SEQ ID NO: 1) or Phe-Gly-Leu-Met-NH2 (SEQ ID NO: 2) with insulin-like growth factor-I exhibits a remarkable promotive action on healing the skin wounds. Accordingly, combined administration of at least one of the substance P analogs and pharmaceutically acceptable salts thereof with the insulin-like growth factor exhibits a promotive effect on epidermal extension and a promotive effect on healing the skin wounds.

摘要翻译： 本发明提供皮肤伤口的愈合促进剂，例如破裂，磨损，手术切口，皮肤溃疡和烧伤。 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH 2（SEQ ID NO：1）或Phe-Gly-Leu-Met-NH 具有胰岛素样生长因子-1的2型（SEQ ID NO：2）对愈合皮肤伤口有显着的促进作用。 因此，至少一种物质P类似物和其药学上可接受的盐与胰岛素样生长因子的组合给药对表皮延伸表现出促进作用，并且对愈合皮肤伤口具有促进作用。

公开(公告)号：US5515180A

公开(公告)日：1996-05-07

申请号：US152975

申请日：1993-11-16

申请人： Hiroshi Maeda ,  Toshio Yamagishi ,  Norihide Kunikawa ,  Toshihiro Okahashi ,  Tatsuya Itoh ,  Masatsugu Nakamura

发明人： Hiroshi Maeda ,  Toshio Yamagishi ,  Norihide Kunikawa ,  Toshihiro Okahashi ,  Tatsuya Itoh ,  Masatsugu Nakamura

IPC分类号： H04N1/40 ,  H04N1/409

CPC分类号： H04N1/4092 ,  H04N1/40087

摘要： The present invention is made to reduce the effect of variation of pulses for driving a printer when recording image data and to improve the gray level representation of picture images to be printed. Data incoming through an image reading device are quantized and processed two pixels at a time by a gray level image processing circuit. The two-pixels' data are first discriminated by an edge discriminator to determine whether they represent an edge portion within the image or not. An object image, on which an operation for inter-pixel spacing shall be conducted, is selected according to the discrimination result. The arithmetic and logic portion performs the above-mentioned operation by two pixels at a time if the data correspond to a non-edge portion and performs correction for enhancement if the data correspond to an edge. This may eliminate the effect of dot displacement due to variation of drive pulses of a printer and improve the quality, in particular, of a gray level image portion.

摘要翻译： 本发明是为了在记录图像数据时减少用于驱动打印机的脉冲变化的影响，并且改善要打印的图像的灰度级表示。 通过图像读取装置输入的数据由灰度级图像处理电路一次量化并处理两个像素。 首先由边缘鉴别器鉴别双像素数据，以确定它们是否代表图像内的边缘部分。 根据鉴别结果选择要进行像素间间隔操作的对象图像。 如果数据对应于非边缘部分，则算术和逻辑部分一次执行上述操作两个像素，并且如果数据对应于边缘，则执行用于增强的校正。 这可以消除由于打印机的驱动脉冲的变化引起的点位移的影响，并且提高了质量，特别是灰度级图像部分的质量。

公开(公告)号：US4683186A

公开(公告)日：1987-07-28

申请号：US786046

申请日：1985-10-10

申请人： Kunio Ohashi ,  Tadashi Tonegawa ,  Shoichi Nagata ,  Masatsugu Nakamura

发明人： Kunio Ohashi ,  Tadashi Tonegawa ,  Shoichi Nagata ,  Masatsugu Nakamura

IPC分类号： G03G5/082 ,  H01L31/09 ,  H01L31/20 ,  G03C5/08 ,  G03C5/04

CPC分类号： G03G5/08242 ,  G03G5/08228 ,  H01L31/095 ,  H01L31/202 ,  Y02E10/50 ,  Y02P70/521

摘要： A photoconductive device including a conductive substrate, a photoconductive layer of amorphous silicon containing at least hydrogen and a surface protection layer applied on the photoconductive layer a dopant is added in the photoconductive layer at least near the interface with the surface protection layer, and the concentration of the dopant increases in the direction perpendicular to the interface. The surface protection layer has an optical energy gap larger than that of the photoconductive layer.A further photoconductive device comprising a conductive substrate; a photoconductive layer of amorphous silicon applied on the conductive substrate and a surface protection layer of amorphous silicon applied on said photoconductive layer wherein the surface protection layer contains oxygen, and is doped with a IIIb element.

摘要翻译： 包含导电衬底，至少含有氢的非晶硅的光电导层和施加在光电导层上的表面保护层掺杂剂的光电导器件至少在与表面保护层的界面附近的光电导层中添加，并且浓度 的掺杂剂在垂直于界面的方向上增加。 表面保护层的光能隙大于光电导层的光学能隙。 一种另外的光电导器件，包括导电衬底; 施加在导电基板上的非晶硅光电导层和施加在所述光电导层上的非晶硅表面保护层，其中表面保护层含有氧，并掺杂有IIIb元素。

公开(公告)号：US09542000B2

公开(公告)日：2017-01-10

申请号：US13371132

申请日：2012-02-10

申请人： Yasuhiro Ueno ,  Masatsugu Nakamura

发明人： Yasuhiro Ueno ,  Masatsugu Nakamura

IPC分类号： G06F3/01 ,  G06F3/0488

CPC分类号： G06F3/016 ,  G06F3/04886

摘要： An object of the present invention is to provide corresponding tactile sensations in accordance with a characteristic of an image displayed. Specifically, an electronic device 10 according to the present invention includes a display unit 102 configured to display an image, a touch sensor 103 configured to detect a touch, a tactile sensation providing unit 104 configured to provide the tactile sensation to a touch face of the touch sensor 103, and a control unit 109 configured to divide the image into a plurality of areas and, when the touch sensor detects the touch to a position corresponding to any of the plurality of areas, to control the tactile sensation providing unit 104 to provide the tactile sensation associated with the area.

摘要翻译： 本发明的目的是提供根据所显示的图像的特征的相应的触感。 具体地，根据本发明的电子设备10包括被配置为显示图像的显示单元102，被配置为检测触摸的触摸传感器103，触觉提供单元104，其被配置为向触摸面提供触觉 触摸传感器103和被配置为将图像分割成多个区域的控制单元109，并且当触摸传感器检测到对应于多个区域中的任一个的位置的触摸时，控制触觉提供单元104提供 与该地区相关的触觉。

公开(公告)号：US20130278536A1

公开(公告)日：2013-10-24

申请号：US13996434

申请日：2011-12-22

申请人： Masatsugu Nakamura ,  Yasuhiro Ueno

发明人： Masatsugu Nakamura ,  Yasuhiro Ueno

IPC分类号： G08B6/00 ,  G06F3/041

CPC分类号： G08B6/00 ,  G06F3/016 ,  G06F3/0416 ,  G06F3/0488

摘要： An electronic device includes a display unit 13, a panel 11, a tactile sensation providing unit 12 configured to vibrate a touch face of the panel 11, and a control unit 16 configured, when detecting contact to a tactile sensation providing area of the touch face corresponding to a predetermined word displayed on the display unit 13, to drive the tactile sensation providing unit 12 based on tactile sensation providing information associated with the predetermined word, such that a tactile sensation is provided to a contact object in contact with the tactile sensation providing area.

摘要翻译： 电子设备包括：显示单元13，面板11，被配置为使面板11的触摸面振动的触觉提供单元12;以及控制单元16，当检测到与触摸面的触感提供区域的接触时 对应于在显示单元13上显示的预定单词，以基于提供与预定单词相关联的信息的触感来驱动触感提供单元12，使得触觉感觉被提供给与提供的触觉相关的接触对象 区。