-
公开(公告)号：US07250537B2
公开(公告)日：2007-07-31
申请号：US10553792
申请日：2004-03-30
申请人： Masayuki Shirai , Chandrashekhar Vasant Rode , Uday Dattopant Joshi , Kazuo Torii , Takafumi Sato
发明人： Masayuki Shirai , Chandrashekhar Vasant Rode , Uday Dattopant Joshi , Kazuo Torii , Takafumi Sato
CPC分类号： C07C29/20 , C07C29/145 , C07C45/006 , C07C2601/14 , C07C2602/10 , C07C2602/28 , Y02P20/52 , C07C49/403 , C07C49/67 , C07C35/08 , C07C35/36
摘要： The present invention provides a novel method of hydrogenating a phenol for hydrogenating a phenol industrially advantageously. The present invention relates, in the case of phenol hydrogenation in which carbon dioxide is made to participate in the reaction, to a method of hydrogenating a phenol characterized by using a supported rhodium and/or ruthenium catalyst, whereby the phenol is hydrogenated efficiently at a lower reaction temperature than with prior art; such a method characterized in that carbon dioxide having a temperature of 20 to 250° C. and a pressure of 0.1 to 50 MPa is used as the carbon dioxide; and such a method characterized in that hydrogen under conditions of a temperature of 20 to 250° C. and a pressure of 0.1 to 50 MPa is used.An environmentally friendly phenol hydrogenation process that uses no harmful organic solvents can be realized.
摘要翻译： 本发明提供了一种氢化苯酚以在工业上有利地氢化酚的新方法。 本发明涉及在其中使二氧化碳参与反应的苯酚氢化的情况下，以使用负载的铑和/或钌催化剂为特征的苯酚氢化方法，由此苯酚在 比现有技术低的反应温度; 这种方法的特征在于使用温度为20〜250℃，压力为0.1〜50MPa的二氧化碳作为二氧化碳; 其特征在于，在温度为20〜250℃，压力为0.1〜50MPa的条件下使用氢。 可以实现不使用有害有机溶剂的环保酚加氢方法。
-
公开(公告)号：US20060194989A1
公开(公告)日：2006-08-31
申请号：US10553792
申请日：2004-03-30
申请人： Masayuki Shirai , Chandrashekhar Rode , Uday Joshi , Kazuo Torii , Takafumi Sato
发明人： Masayuki Shirai , Chandrashekhar Rode , Uday Joshi , Kazuo Torii , Takafumi Sato
IPC分类号： C07C49/175
CPC分类号： C07C29/20 , C07C29/145 , C07C45/006 , C07C2601/14 , C07C2602/10 , C07C2602/28 , Y02P20/52 , C07C49/403 , C07C49/67 , C07C35/08 , C07C35/36
摘要： The present invention provides a novel method of hydrogenating a phenol for hydrogenating a phenol industrially advantageously. The present invention relates, in the case of phenol hydrogenation in which carbon dioxide is made to participate in the reaction, to a method of hydrogenating a phenol characterized by using a supported rhodium and/or ruthenium catalyst, whereby the phenol is hydrogenated efficiently at a lower reaction temperature than with prior art; such a method characterized in that carbon dioxide having a temperature of 20 to 250° C. and a pressure of 0.1 to 50 MPa is used as the carbon dioxide; and such a method characterized in that hydrogen under conditions of a temperature of 20 to 250° C. and a pressure of 0.1 to 50 MPa is used. An environmentally friendly phenol hydrogenation process that uses no harmful organic solvents can be realized.
摘要翻译： 本发明提供了一种氢化苯酚以在工业上有利地氢化酚的新方法。 本发明涉及在其中使二氧化碳参与反应的苯酚氢化的情况下，以使用负载的铑和/或钌催化剂为特征的苯酚氢化方法，由此苯酚在 比现有技术低的反应温度; 这种方法的特征在于使用温度为20〜250℃，压力为0.1〜50MPa的二氧化碳作为二氧化碳; 其特征在于，在温度为20〜250℃，压力为0.1〜50MPa的条件下使用氢。 可以实现不使用有害有机溶剂的环保酚加氢方法。
-
公开(公告)号：US20110150896A1
公开(公告)日：2011-06-23
申请号：US12863983
申请日：2009-01-08
CPC分类号： C07K16/1214 , C07K2317/76 , C07K2317/92
摘要： Provided is an effective means for therapy of infection, particularly infection with Pseudomonas aeruginosa. Provided are a monoclonal antibody against PcrV or a part thereof, and a pharmaceutical composition containing the same as an active ingredient. Concretely, monoclonal antibody of the present invention has excellent inhibiting activity on cytotoxicity with respect to a target cell of Pseudomonas aeruginosa. Also, the monoclonal antibody of the present invention has high affinity with PcrV.
摘要翻译： 提供治疗感染，特别是铜绿假单胞菌感染的有效手段。 提供了针对PcrV或其一部分的单克隆抗体，以及含有其作为活性成分的药物组合物。 具体地，本发明的单克隆抗体相对于铜绿假单胞菌的靶细胞的细胞毒性具有优异的抑制活性。 此外，本发明的单克隆抗体与PcrV具有高亲和力。
-
公开(公告)号：US20130274348A1
公开(公告)日：2013-10-17
申请号：US13820108
申请日：2011-08-31
申请人： Takafumi Sato , Motohiro Ota , Makoto Kigoshi , Hideki Morita
发明人： Takafumi Sato , Motohiro Ota , Makoto Kigoshi , Hideki Morita
IPC分类号： A61K9/00
CPC分类号： A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K31/454
摘要： It is an object of the present invention to provide an orally disintegrating tablet that has desirable oral disintegrability and excellent tablet hardness, a process for producing the same, and the like.The present invention provides an orally disintegrating tablet comprising: at least one diluent selected from D-mannitol, lactose, trehalose, xylitol, maltitol, and erythritol; a drug; a disintegrant; and at least one binder selected form methacrylic acid copolymer S, methacrylic acid copolymer L, methacrylic acid-ethyl acrylate copolymer, ethyl acrylate-methyl methacrylate copolymer, and methyl methacrylate-butyl methacrylate-dimethylaminoethyl methacrylate copolymer.
摘要翻译： 本发明的目的是提供一种口腔崩解片，其具有理想的口腔崩解性和优异的片剂硬度，其制备方法等。 本发明提供一种口腔崩解片，其包含：至少一种选自D-甘露糖醇，乳糖，海藻糖，木糖醇，麦芽糖醇和赤藓糖醇的稀释剂; 一种药物 崩解剂 和至少一种选自甲基丙烯酸共聚物S，甲基丙烯酸共聚物L，甲基丙烯酸 - 丙烯酸乙酯共聚物，丙烯酸乙酯 -
-
公开(公告)号：US09861577B2
公开(公告)日：2018-01-09
申请号：US13820108
申请日：2011-08-31
申请人： Takafumi Sato , Motohiro Ota , Makoto Kigoshi , Hideki Morita
发明人： Takafumi Sato , Motohiro Ota , Makoto Kigoshi , Hideki Morita
IPC分类号： A61K9/00 , A61K9/20 , A61K31/454
CPC分类号： A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K31/454
摘要： It is an object of the present invention to provide an orally disintegrating tablet that has desirable oral disintegrability and excellent tablet hardness, a process for producing the same, and the like.The present invention provides an orally disintegrating tablet comprising: at least one diluent selected from D-mannitol, lactose, trehalose, xylitol, maltitol, and erythritol; a drug; a disintegrant; and at least one binder selected form methacrylic acid copolymer S, methacrylic acid copolymer L, methacrylic acid-ethyl acrylate copolymer, ethyl acrylate-methyl methacrylate copolymer, and methyl methacrylate-butyl methacrylate-dimethylaminoethyl methacrylate copolymer.
-
公开(公告)号：US08501179B2
公开(公告)日：2013-08-06
申请号：US12863983
申请日：2009-01-08
IPC分类号： A61K39/40
CPC分类号： C07K16/1214 , C07K2317/76 , C07K2317/92
摘要： Provided is an effective means for therapy of infection, particularly infection with Pseudomonas aeruginosa. Provided are a monoclonal antibody against PcrV or a part thereof, and a pharmaceutical composition containing the same as an active ingredient. Concretely, monoclonal antibody of the present invention has excellent inhibiting activity on cytotoxicity with respect to a target cell of Pseudomonas aeruginosa. Also, the monoclonal antibody of the present invention has high affinity with PcrV.
摘要翻译： 提供治疗感染，特别是铜绿假单胞菌感染的有效手段。 提供了针对PcrV或其一部分的单克隆抗体，以及含有其作为活性成分的药物组合物。 具体地，本发明的单克隆抗体相对于铜绿假单胞菌的靶细胞的细胞毒性具有优异的抑制活性。 此外，本发明的单克隆抗体与PcrV具有高亲和力。
-
公开(公告)号：US08481753B2
公开(公告)日：2013-07-09
申请号：US12864618
申请日：2008-12-24
申请人： Satoshi Ito , Naotsugu Itoh , Takafumi Sato
发明人： Satoshi Ito , Naotsugu Itoh , Takafumi Sato
IPC分类号： C07D209/44
CPC分类号： C07D209/44 , C07D209/72 , C07D487/22 , C07F5/022 , Y02P20/544
摘要： A method for manufacturing isoindolic compound, which can adopt a condition capable of being put to industrially practical use, which can produce stable isoindolic compound, and which can further produce the isoindolic compound with a high yield. The method for manufacturing isoindolic compound includes a thermal treatment step where a compound of which molecule includes a structure of pyrrole fused with bicyclo [2.2.2] octadiene skeleton, and includes a formula (I): is subjected to a supercritical carbon dioxide atmosphere. The thermal treatment step is preferably performed at a temperature of not less than 50° C. and not more than 300° C.
摘要翻译： 可以采用能够在工业上实际应用的条件的异吲哚化合物的制造方法，其可以产生稳定的异吲哚类化合物，并且可以以高产率进一步生产异吲哚类化合物。 异吲哚化合物的制造方法包括热处理步骤，其中分子包含与双环[2.2.2]辛二烯骨架稠合的吡咯结构的化合物，并包括式（I）：经受超临界二氧化碳气氛。 热处理步骤优选在不低于50℃且不超过300℃的温度下进行。
-
公开(公告)号：US20110137024A1
公开(公告)日：2011-06-09
申请号：US12864618
申请日：2008-12-24
申请人： Satoshi Ito , Naotsugu Itoh , Takafumi Sato
发明人： Satoshi Ito , Naotsugu Itoh , Takafumi Sato
IPC分类号： C07D487/22 , C07D209/44
CPC分类号： C07D209/44 , C07D209/72 , C07D487/22 , C07F5/022 , Y02P20/544
摘要： Disclosed is a method for manufacturing isoindolic compound, which can adopt a condition capable of being put to industrially practical use, which can produce stable isoindolic compound, and which can further produce the isoindolic compound with a high yield. The method for manufacturing isoindolic compound comprises a thermal treatment step where a compound of which molecule includes a structure of pyrrole fused with bicyclo [2.2.2] octadiene skeleton is subjected to a supercritical carbon dioxide atmosphere. The thermal treatment step is preferably performed at a temperature of not less than 50° C. and not more than 300° C.
摘要翻译： 公开了一种可以采用能够在工业上实际使用的条件的异吲哚类化合物的制造方法，其可以制造稳定的异吲哚啉化合物，并且可以以高产率进一步生产异吲哚啉化合物。 异吲哚化合物的制造方法包括热处理步骤，其中分子包含与双环[2.2.2]辛二烯骨架稠合的吡咯结构的化合物经受超临界二氧化碳气氛。 热处理步骤优选在不低于50℃且不超过300℃的温度下进行。
-
公开(公告)号：US20070178949A1
公开(公告)日：2007-08-02
申请号：US11460196
申请日：2006-07-26
申请人： Takafumi Sato , Shiro Arita
发明人： Takafumi Sato , Shiro Arita
IPC分类号： H04M1/00
CPC分类号： H04M1/03 , H04M1/0216 , H04M1/035 , H04M1/605 , H04M2250/16
摘要： A mobile terminal able to emit an information sound outwardly even in a case where it is set down in a closed state, in particular a mobile phone including a first housing having a projecting part at one end and having a second housing having a recess in which the projecting part is fitted on one end and having a built-in information speaker, the projecting part being pivotably connected to the inside of the recess so as to enable the first housing and the sender housing to be opened and closed, wherein a top surface of the projecting part is located at an inside from the plane including a back surface of the sender housing on an opposite side to a facing surface in the closed state of the mobile phone, a space is provided between the projecting part and the recess, and sound emission ports for emitting sound from the information speaker are provided in a wall surface of the recess forming that space.
摘要翻译： 即使在其处于关闭状态的情况下也能够向外发出信息的移动终端，特别是包括在一端具有突出部分的第一壳体的移动电话，并且具有凹部的第二壳体， 突出部分安装在一端并具有内置的信息扬声器，突出部分可枢转地连接到凹部的内部，以使第一壳体和发送器壳体能够打开和关闭，其中顶表面 所述突出部位于与所述移动电话的关闭状态下的与所述面对面相反的一侧的所述平面的内部，所述平面包括所述发送器壳体的背面，所述突出部与所述凹部之间设置有空间， 用于从信息扬声器发出声音的声音发射端口设置在形成该空间的凹部的壁表面中。
-
公开(公告)号：US20120093808A1
公开(公告)日：2012-04-19
申请号：US13256219
申请日：2010-03-09
CPC分类号： C07K16/1214 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Provided are a humanized monoclonal antibody against PcrV or a part thereof, and a pharmaceutical composition containing the same as an active ingredient, as an effective means for therapy of infection, particularly infection with Pseudomonas aeruginosa. Concretely, the humanized monoclonal antibody of the present invention has an excellent inhibitory activity on the cytotoxicity with respect to a target cell of Pseudomonas aeruginosa. Also, the humanized monoclonal antibody of the present invention has a high affinity for PcrV.
摘要翻译： 提供了抗PcrV或其一部分的人源化单克隆抗体，以及含有其作为活性成分的药物组合物，作为感染治疗，特别是铜绿假单胞菌感染的有效手段。 具体而言，本发明的人源化单克隆抗体相对于铜绿假单胞菌的靶细胞的细胞毒性具有优异的抑制活性。 此外，本发明的人源化单克隆抗体对PcrV具有高亲和力。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.029 秒)
