公开(公告)号：US4287221A

公开(公告)日：1981-09-01

申请号：US109117

申请日：1980-01-02

申请人： Masayuki Tonedachi ,  Fujio Sekigawa ,  Katsuyoshi Minemura

发明人： Masayuki Tonedachi ,  Fujio Sekigawa ,  Katsuyoshi Minemura

IPC分类号： A61K47/38 ,  A61K9/28 ,  A61K9/32 ,  A61K9/36 ,  A61K9/48

CPC分类号： A61K9/4891 ,  A61K9/2866

摘要： The invention provides a novel method for providing entric coating on solid dosage forms using an aqueous coating liquid so that the problems inherent to the use of a coating liquid in an organic solvent can completely be eliminated. The inventive method comprises dispersing a finely divided powder of a hydroxypropylmethylcellulose phthalate in an aqueous medium containing triacetin to give an aqueous coating liquid with which the solid dosage forms are coated, for example, by spraying and dried. It is necessary that the preparation of the coating liquid and the coating procedure with the coating liquid are performed throughout while keeping the temperature of the liquid below 25.degree. C. so as that the particles of the hydroxypropylmethylcellulose phthalate are not dissolved in the medium forming a stable dispersion without adhesive coalescence.

摘要翻译： 本发明提供一种使用水性涂布液在固体剂型上提供中心涂层的新方法，从而可以完全消除在有机溶剂中使用涂布液所固有的问题。 本发明的方法包括将细分散的邻苯二甲酸羟丙基甲基纤维素的粉末分散在含有三醋精的水性介质中，得到例如通过喷雾和干燥涂覆固体剂型的水性涂布液。 必须在保持液体温度低于25℃的同时进行涂布液的制备和涂布液的涂布操作，以使邻苯二甲酸羟丙基甲基纤维素的颗粒不溶解在形成介质的介质中 稳定的分散无粘合剂聚结。