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公开(公告)号：US20150164795A1
公开(公告)日：2015-06-18
申请号：US14539550
申请日：2014-11-12
申请人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： A61K9/12 , A61K45/06 , A61K31/4545
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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公开(公告)号：US08173815B2
公开(公告)日：2012-05-08
申请号：US13226677
申请日：2011-09-07
申请人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： C07D211/00
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar1，R1，R2，R3，R4，R6，R7和R8如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US07803812B2
公开(公告)日：2010-09-28
申请号：US12437766
申请日：2009-05-08
申请人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar1，R1，R2，R3，R4，R6，R7和R8如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US09452161B2
公开(公告)日：2016-09-27
申请号：US15016528
申请日：2016-02-05
申请人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： C07D401/00 , A61K31/44 , A61K31/4545 , A61K9/16 , A61K45/06
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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公开(公告)号：US20160220551A1
公开(公告)日：2016-08-04
申请号：US15016528
申请日：2016-02-05
申请人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： A61K31/4545 , A61K45/06 , A61K9/16
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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公开(公告)号：US08119796B2
公开(公告)日：2012-02-21
申请号：US13193874
申请日：2011-07-29
申请人： YuHua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
发明人： YuHua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
IPC分类号： C07D417/14 , C07D265/28 , C07D401/14 , A61K31/54 , A61K31/5377 , A61K31/496
CPC分类号： C07D211/46 , C07D405/12 , C07D409/12 , C07D487/08
摘要： The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，m，s，t，w，Z，Ar，R 1，R 2，R 3，R 6和R 7如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US08013152B2
公开(公告)日：2011-09-06
申请号：US12759887
申请日：2010-04-14
申请人： YuHua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
发明人： YuHua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
IPC分类号： C07D265/28 , C07D241/04 , A61K31/54 , A61K31/5375
CPC分类号： C07D211/46 , C07D405/12 , C07D409/12 , C07D487/08
摘要： The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，m，s，t，w，Z，Ar，R 1，R 2，R 3，R 6和R 7如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US07868175B2
公开(公告)日：2011-01-11
申请号：US12582865
申请日：2009-10-21
申请人： YuHua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric L. Stangeland
发明人： YuHua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric L. Stangeland
IPC分类号： C07D401/04 , A61K31/444
CPC分类号： C07D405/14 , C07D211/62 , C07D401/12 , C07D409/14
摘要： The invention provides compounds of formula I: wherein a, b, c, d, n, R1, R2, R3, R6, R7, W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，n，R 1，R 2，R 3，R 6，R 7，W和A如说明书中所定义。 式I的化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US08912334B2
公开(公告)日：2014-12-16
申请号：US14023794
申请日：2013-09-11
申请人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： C07D401/00 , A61K31/44 , C07D211/62 , C07D401/12 , A61K45/06 , A61K31/4545
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar1，R1，R2，R3，R4，R6，R7和R8如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20140171397A1
公开(公告)日：2014-06-19
申请号：US14023794
申请日：2013-09-11
申请人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , YuHua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： C07D401/12 , A61K45/06 , A61K31/4545
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar1，R1，R2，R3，R4，R6，R7和R8如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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