公开(公告)号：US12226525B2

公开(公告)日：2025-02-18

申请号：US17133980

申请日：2020-12-24

Applicant: Mati Therapeutics, Inc.

Inventor： Eugene de Juan, Jr. ,  Stephen Boyd ,  Cary J. Reich ,  Alan R. Rapacki ,  Hanson S. Gifford ,  Mark Deem

IPC: A61K9/00 ,  A61F9/00 ,  A61F9/007 ,  A61K9/06 ,  A61K31/215 ,  A61K31/216 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/573 ,  A61K47/34 ,  A61L31/16

Abstract: An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.

公开(公告)号：US11406592B2

公开(公告)日：2022-08-09

申请号：US16168335

申请日：2018-10-23

Applicant: Mati Therapeutics Inc.

Inventor： Eugene de Juan, Jr. ,  Cary Reich ,  Stephen Boyd ,  Hanson S. Gifford, III ,  Mark Deem

IPC: A61K9/00 ,  A61F9/007 ,  A61F9/00 ,  A61K31/216 ,  A61K31/5575 ,  A61K47/34 ,  A61K31/573 ,  A61K31/557 ,  A61K31/55 ,  A61L31/16 ,  A61K31/215 ,  A61K9/06

Abstract: An implant for insertion into a punctum of a patient comprises a body. The body has a distal end, a proximal end, and an axis therebetween. The distal end of the body is insertable distally through the punctum into the canalicular lumen. The body comprises a therapeutic agent included within an agent matrix drug core. Exposure of the agent matrix to the tear fluid effects an effective therapeutic agent release into the tear fluid over a sustained period. The body has a sheath disposed over the agent matrix to inhibit release of the agent away from the proximal end. The body also has an outer surface configured to engage luminal wall tissues so as to inhibit expulsion when disposed therein. In specific embodiments, the agent matrix comprises a non-bioabsorbable polymer, for example silicone in a non-homogenous mixture with the agent.

公开(公告)号：US11141312B2

公开(公告)日：2021-10-12

申请号：US14690874

申请日：2015-04-20

Applicant: Mati Therapeutics Inc.

Inventor： Eugene de Juan, Jr. ,  Stephen Boyd ,  Cary J. Reich ,  Christopher V. Cardenas ,  Tommy Jewell ,  Lorrie Ma ,  Tuan Nguyen

IPC: A61F9/00 ,  A61B5/06 ,  A61B5/00 ,  G01R33/02 ,  G01R33/07 ,  A61F9/007 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  A61L31/16 ,  A61B8/08

Abstract: This document discusses, among other things, an apparatus comprising a lacrimal implant insertable at least partially into a lacrimal punctum. The lacrimal implant comprises an implant core, and an implant body. The implant body includes a cavity sized and shaped to receive the implant core. At least one of the implant core and the implant cavity includes a detection device configured to allow automatic detection of the lacrimal implant with a separate detector device.

公开(公告)号：US10383817B2

公开(公告)日：2019-08-20

申请号：US15852619

申请日：2017-12-22

Applicant: Mati Therapeutics Inc.

Inventor： Eugene de Juan, Jr. ,  Stephen Boyd ,  Cary Reich ,  Alan Rapacki ,  Hanson S Gifford ,  Mark Deem

IPC: A61K9/00 ,  A61K31/557 ,  A61K31/55 ,  A61L31/16 ,  A61F9/00 ,  A61F9/007 ,  A61K31/215 ,  A61K31/216 ,  A61K31/5575 ,  A61K47/34 ,  A61K9/06 ,  A61K31/573

Abstract: An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.

公开(公告)号：US10300014B2

公开(公告)日：2019-05-28

申请号：US16168554

申请日：2018-10-23

Applicant: Mati Therapeutics Inc.

Inventor： Eugene de Juan, Jr. ,  Cary Reich ,  Stephen Boyd ,  Hanson S. Gifford ,  Mark Deem ,  Alan Rapacki

IPC: A61F9/00 ,  A61K9/00 ,  A61K31/557 ,  A61K31/55 ,  A61L31/16 ,  A61F9/007 ,  A61K31/215 ,  A61K31/216 ,  A61K31/5575 ,  A61K47/34 ,  A61K9/06 ,  A61K31/573

Abstract: An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.

公开(公告)号：US20170128361A1

公开(公告)日：2017-05-11

申请号：US15405991

申请日：2017-01-13

Applicant: Mati Therapeutics Inc.

Inventor： Eugene de Juan, Jr. ,  Stephen Boyd ,  Cary Reich ,  Alan Rapacki ,  Hanson S Gifford ,  Mark Deem

IPC: A61K9/00 ,  A61K31/5575 ,  A61K31/573 ,  A61F9/007 ,  A61K9/06

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61F9/0026 ,  A61F9/00772 ,  A61F9/00781 ,  A61F2220/0008 ,  A61F2250/0067 ,  A61F2250/0087 ,  A61K9/00 ,  A61K9/0017 ,  A61K9/06 ,  A61K31/215 ,  A61K31/216 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/573 ,  A61K47/34 ,  A61L31/16

Abstract: An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.

公开(公告)号：US08691265B2

公开(公告)日：2014-04-08

申请号：US13645261

申请日：2012-10-04

Applicant: Mati Therapeutics, Inc.

Inventor： Eugene de Juan, Jr. ,  Stephen Boyd ,  Hanson S. Gifford, III ,  Mark Deem ,  Cary J. Reich

IPC: A61F13/00 ,  A61F2/00

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61F9/0026 ,  A61F9/00772 ,  A61F9/00781 ,  A61F2220/0008 ,  A61F2250/0067 ,  A61F2250/0087 ,  A61K9/00 ,  A61K9/0017 ,  A61K9/06 ,  A61K31/215 ,  A61K31/216 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/573 ,  A61K47/34 ,  A61L31/16

Abstract: A drug insert is configured for use with an implant. The implant is configured for insertion into a lacrimal canaliculus. The drug insert includes a drug core comprising a therapeutic agent and a polymer; and a sheath body comprising material substantially impermeable to the therapeutic agent, wherein the drug core is positioned within the sheath body. The sheath body is configured to provide an exposed end of the drug core that releases therapeutic agent to an eye when the drug insert is disposed within the implant and the implant is positioned in the lacrimal canaliculus. A distal end of the drug core is sealed with a medical-grade adhesive.

Abstract translation: 药物插入物配置成与植入物一起使用。 植入物构造成用于插入泪小管。 药物插入物包括药物核心，其包含治疗剂和聚合物; 以及鞘体，其包含基本上不可渗透到治疗剂的材料，其中所述药物核心位于所述鞘体内。 护套主体构造成当药物插入物设置在植入物内并且植入物位于泪小管中时，提供药物核心的暴露端​​，其将治疗剂释放到眼睛。 药物核心的远端用医用级粘合剂密封。

公开(公告)号：US09849082B2

公开(公告)日：2017-12-26

申请号：US15405991

申请日：2017-01-13

Applicant: Mati Therapeutics Inc.

Inventor： Eugene de Juan, Jr. ,  Stephen Boyd ,  Cary Reich ,  Alan Rapacki ,  Hanson S Gifford ,  Mark Deem

IPC: A61L31/16 ,  A61K9/00 ,  A61K31/557 ,  A61K31/55 ,  A61F9/00 ,  A61F9/007 ,  A61K31/215 ,  A61K31/216 ,  A61K31/5575 ,  A61K47/34 ,  A61K9/06 ,  A61K31/573

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61F9/0026 ,  A61F9/00772 ,  A61F9/00781 ,  A61F2220/0008 ,  A61F2250/0067 ,  A61F2250/0087 ,  A61K9/00 ,  A61K9/0017 ,  A61K9/06 ,  A61K31/215 ,  A61K31/216 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/573 ,  A61K47/34 ,  A61L31/16

Abstract: An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.

公开(公告)号：US09549852B2

公开(公告)日：2017-01-24

申请号：US14858555

申请日：2015-09-18

Applicant: Mati Therapeutics Inc.

Inventor： Eugene de Juan, Jr. ,  Stephen Boyd ,  Cary Reich ,  Alan Rapacki ,  Hanson S Gifford ,  Mark Deem

IPC: A61K9/08 ,  A61F9/007 ,  A61K31/557 ,  A61K31/55 ,  A61F9/00 ,  A61K31/215 ,  A61K9/00 ,  A61K31/216 ,  A61K31/5575 ,  A61K47/34

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61F9/0026 ,  A61F9/00772 ,  A61F9/00781 ,  A61F2220/0008 ,  A61F2250/0067 ,  A61F2250/0087 ,  A61K9/00 ,  A61K9/0017 ,  A61K9/06 ,  A61K31/215 ,  A61K31/216 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/573 ,  A61K47/34 ,  A61L31/16

Abstract: An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.

Abstract translation: 用于插入通过泪点并进入患者的小管腔的植入物。 植入物包括材料基质，分散在材料基质中的治疗剂，鞘层，其设置在材料基质的一部分上并且被配置为抑制治疗剂从材料基质释放到小管腔内，并且 允许治疗剂从材料基质的表面释放到泪膜，以及构造成将植入物保持在小管腔内的保留结构。