公开(公告)号：US20130078299A1

公开(公告)日：2013-03-28

申请号：US13444348

申请日：2012-04-11

申请人： Matthew HARRITON ,  Gregory Robb ,  Ronald S. Harland

发明人： Matthew HARRITON ,  Gregory Robb ,  Ronald S. Harland

IPC分类号： A61K47/10 ,  A61K9/70 ,  A61K47/36 ,  A61K31/167 ,  A61K47/32

CPC分类号： A61K47/10 ,  A61K9/06 ,  A61K9/70 ,  A61K9/7053 ,  A61K31/167 ,  A61K47/32 ,  A61K47/36

摘要： Crosslinked hydrogel-based transdermal pharmaceutical formulations. The hydrogel transdermal formulations. Transdermal patches are useful for administering a variety of drugs to patients. The transdermal patches here employ crosslinked-hydrogels generated through irradiation, thus eliminating any residual effects associated with chemical- or UV-based crosslinking procedures. The transdermal patches may be formed from a variety of high-molecular weight polymeric compounds and include substantial levels of water to improve skin tolerance by the patient. The transdermal patches may also include transcutol as a solvent for the drug, which has been found to increase the effectiveness of drug delivery. The present disclosure also provides for methods of loading a drug into a transdermal formulation after the crosslinking of the hydrogel, thus improving stability and bioavailability through avoiding exposure of the drug to the radiation used in the crosslinking procedure. The transdermal patches here are particularly effective in delivering lidocaine to patients in need thereof.

摘要翻译： 交联水凝胶基透皮药物制剂。 水凝胶透皮制剂。 透皮贴剂可用于向患者施用各种药物。 这里的透皮贴剂使用通过照射产生的交联水凝胶，从而消除与化学或UV基交联程序相关的任何残留效应。 透皮贴剂可以由多种高分子量聚合物形成，并且包括大量的水以改善患者的皮肤耐受性。 透皮贴剂还可以包括作为药物的溶剂的转酮醇，其被发现增加药物递送的有效性。 本公开还提供了在水凝胶交联后将药物装载到透皮制剂中的方法，从而通过避免药物暴露于交联程序中使用的辐射来提高稳定性和生物利用度。 这里的透皮贴剂特别有效地将利多卡因递送给有需要的患者。