公开(公告)号：US07083791B2

公开(公告)日：2006-08-01

申请号：US10613413

申请日：2003-07-03

申请人： Matthew Sleeman ,  J. Greg Murison

发明人： Matthew Sleeman ,  J. Greg Murison

IPC分类号： A61K38/00 ,  A61K38/16 ,  C07K14/00

CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/715 ,  C07K16/2863 ,  C07K2319/00

摘要： Isolated fibroblast growth factor receptor (FGFR5) polypeptides and polynucleotides encoding such polypeptides are provided. Also provided are modulators of FGFR5 gene expression and binding molecules that specifically bind to and agonize or antagonize FGFR5 polypeptide function. Specific binding molecules include antibodies, functional fragments thereof, as well as scFv and Camelidae heavy chain IgG that specifically bind to FGFR5 thereby modulating the activity of FGFR5 and, thus, are effective agents suitable for the treatment of diseases such as osteopontin-mediated autoimmune disease, such as systemic lupus erythematosus, bone disorders including osteoporosis and osteopetrosis, and cancers, including cellular carcinomas such as hepatocellular carcinomas.

摘要翻译： 提供分离的成纤维细胞生长因子受体（FGFR5）多肽和编码这些多肽的多核苷酸。 还提供了FGFR5基因表达的调节剂和特异性结合并激动或拮抗FGFR5多肽功能的结合分子。 特异性结合分子包括抗体，其功能片段，以及特异性结合FGFR5的scFv和骆驼科重链IgG，从而调节FGFR5的活性，因此是适合于治疗疾病如骨桥蛋白介导的自身免疫疾病 ，例如系统性红斑狼疮，包括骨质疏松症和骨硬化的骨病，和癌症，包括细胞癌如肝细胞癌。