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公开(公告)号：US08912186B2
公开(公告)日：2014-12-16
申请号：US13124773
申请日：2009-10-16
IPC分类号： A01N43/58 , A61K31/50 , C07C59/88 , C07C59/90 , C07D213/55 , C07D307/80 , C07D333/56 , C07D209/18
CPC分类号： C07D209/18 , C07C59/88 , C07C59/90 , C07D213/55 , C07D307/80 , C07D333/56
摘要： The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
摘要翻译： 本发明提供了特异性调节AGC蛋白激酶和Aurora家族蛋白激酶的活性或调节蛋白质 - 蛋白质相互作用的特异性小分子化合物，其生产方法，包含其的药物组合物及其用于制备药物用于治疗和 预防与AGC蛋白激酶或Aurora家族蛋白激酶异常活动有关的疾病。
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公开(公告)号：US20120046307A1
公开(公告)日：2012-02-23
申请号：US13124773
申请日：2009-10-16
IPC分类号： A61K31/517 , A61K31/515 , A61K31/47 , A61K31/4184 , A61K31/404 , A61K31/381 , A61K31/343 , A61K31/192 , C07D239/72 , C07D239/02 , C07D215/14 , C07D235/12 , C07D209/18 , C07D333/56 , C07D307/87 , C07C57/42 , A61P9/12 , A61P35/00 , A61P3/10 , A61P29/00 , A61P37/00 , A61P25/28 , A61P31/00 , C12N9/12
CPC分类号： C07D209/18 , C07C59/88 , C07C59/90 , C07D213/55 , C07D307/80 , C07D333/56
摘要： The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
摘要翻译： 本发明提供了特异性调节AGC蛋白激酶和Aurora家族蛋白激酶的活性或调节蛋白质 - 蛋白质相互作用的特异性小分子化合物，其生产方法，包含其的药物组合物及其用于制备药物用于治疗和 预防与AGC蛋白激酶或Aurora家族蛋白激酶异常活动有关的疾病。
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公开(公告)号：US07629385B2
公开(公告)日：2009-12-08
申请号：US11571354
申请日：2005-06-29
申请人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Fröhner , Gary Jennings , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knölker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
发明人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Fröhner , Gary Jennings , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knölker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
CPC分类号： A61K31/133 , Y02A50/475
摘要： The present invention relates to specific sphingolipids/sphingolipid derivatives as pharmaceutical compositions as well as their use in the preparation of medicaments for the treatment, prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.
摘要翻译： 本发明涉及作为药物组合物的特定鞘脂/鞘脂衍生物及其在制备用于治疗，预防和/或改善与脂筏中的病理过程有关的疾病的药物中的用途。
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公开(公告)号：US20100063126A1
公开(公告)日：2010-03-11
申请号：US11571351
申请日：2005-06-29
申请人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Fröhner , Gary Jennings , Georg Schlechtingen , Cornella Schroeder , Hans-Joachim Knölker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
发明人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Fröhner , Gary Jennings , Georg Schlechtingen , Cornella Schroeder , Hans-Joachim Knölker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
IPC分类号： A61K31/403
CPC分类号： A61K31/40 , Y02A50/475
摘要： The present invention relates to the use of specific carbazole derivatives in the preparation of medicaments for the treatment, prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.
摘要翻译： 本发明涉及特定咔唑衍生物在制备用于治疗，预防和/或改善与脂筏病理过程有关的疾病的药物中的用途。
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