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1.发明申请公开(公告)号：US20070032474A1
公开(公告)日：2007-02-08
申请号：US10559971
申请日：2004-06-10
申请人： Ricardo Biondi , Matthias Engel
发明人： Ricardo Biondi , Matthias Engel
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/415 , A61K31/165 , C07D417/02 , C07D413/02 , C07D403/02 , A61K31/395
CPC分类号： C07D213/75 , C07C233/15 , C07C233/87 , C07C323/52 , C07D215/38
摘要： The invention relates to a compound of formula I or pharmaceutically acceptable salts thereof. The invention further relates to methods of use of this compound.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐。 本发明还涉及该化合物的使用方法。
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公开(公告)号：US08912186B2
公开(公告)日：2014-12-16
申请号：US13124773
申请日：2009-10-16
IPC分类号： A01N43/58 , A61K31/50 , C07C59/88 , C07C59/90 , C07D213/55 , C07D307/80 , C07D333/56 , C07D209/18
CPC分类号： C07D209/18 , C07C59/88 , C07C59/90 , C07D213/55 , C07D307/80 , C07D333/56
摘要： The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
摘要翻译： 本发明提供了特异性调节AGC蛋白激酶和Aurora家族蛋白激酶的活性或调节蛋白质 - 蛋白质相互作用的特异性小分子化合物，其生产方法，包含其的药物组合物及其用于制备药物用于治疗和 预防与AGC蛋白激酶或Aurora家族蛋白激酶异常活动有关的疾病。
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公开(公告)号：US20120046307A1
公开(公告)日：2012-02-23
申请号：US13124773
申请日：2009-10-16
IPC分类号： A61K31/517 , A61K31/515 , A61K31/47 , A61K31/4184 , A61K31/404 , A61K31/381 , A61K31/343 , A61K31/192 , C07D239/72 , C07D239/02 , C07D215/14 , C07D235/12 , C07D209/18 , C07D333/56 , C07D307/87 , C07C57/42 , A61P9/12 , A61P35/00 , A61P3/10 , A61P29/00 , A61P37/00 , A61P25/28 , A61P31/00 , C12N9/12
CPC分类号： C07D209/18 , C07C59/88 , C07C59/90 , C07D213/55 , C07D307/80 , C07D333/56
摘要： The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
摘要翻译： 本发明提供了特异性调节AGC蛋白激酶和Aurora家族蛋白激酶的活性或调节蛋白质 - 蛋白质相互作用的特异性小分子化合物，其生产方法，包含其的药物组合物及其用于制备药物用于治疗和 预防与AGC蛋白激酶或Aurora家族蛋白激酶异常活动有关的疾病。
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