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公开(公告)号：US20100021529A1
公开(公告)日：2010-01-28
申请号：US12304600
申请日：2007-06-13
IPC分类号： A61K31/566 , A61P5/30 , A61K9/70
CPC分类号： A61K31/565 , A61K2300/00
摘要： The present invention relates to methods for continuous treatment of diseases, conditions and/or symptoms associated with deficient endogenous levels of estrogen in a woman already receiving a therapeutically effective dose of an estrogen. More particularly, the present invention provides a safe and efficient step-down regimen for women already receiving estrogen therapy and which are potentially overdosed.
摘要翻译： 本发明涉及用于连续治疗已经接受治疗有效剂量的雌激素的女性中雌激素缺乏的疾病，病症和/或症状的方法。 更具体地，本发明为已经接受雌激素治疗并且潜在过量的妇女提供了一种安全有效的降压方案。
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公开(公告)号：US20080021003A1
公开(公告)日：2008-01-24
申请号：US11761616
申请日：2007-06-12
CPC分类号： A61K31/565 , A61K2300/00
摘要： The present invention relates to methods for treating diseases, conditions or symptoms associated with deficient endogenous levels of estrogen comprising administration of a higher first dose of an estrogen followed by administration of a lower second dose of an estrogen once therapy has been effectively established. The invention further relates to a combination treatment comprising administration of an estrogen and a progestin.
摘要翻译： 本发明涉及用于治疗与内源性雌激素水平不足相关的疾病，病症或症状的方法，包括施用较高的第一剂雌激素，然后施用较低的第二剂量的雌激素，一旦有效地建立了治疗。 本发明还涉及包括施用雌激素和孕激素的组合治疗。
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公开(公告)号：US20110136825A1
公开(公告)日：2011-06-09
申请号：US12675231
申请日：2008-09-11
申请人： Vladimir Hanes , Annelies Verbeek
发明人： Vladimir Hanes , Annelies Verbeek
IPC分类号： A61K31/496 , A61P25/00 , A61P9/00
CPC分类号： A61K31/496 , A61P15/12
摘要： The invention relates to a method for the treatment of vasomotor symptoms comprising the administration of a therapeutically effective amount of flibanserin.
摘要翻译： 本发明涉及一种用于治疗血管舒缩症状的方法，其包括施用治疗有效量的弗来班西林。
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公开(公告)号：US20090142313A1
公开(公告)日：2009-06-04
申请号：US12275115
申请日：2008-11-20
IPC分类号： A61K31/585 , A61P31/04 , A61P31/10 , A61K35/74
CPC分类号： A61K31/56 , A61K9/0036 , A61K31/565 , A61K31/585 , A61K2300/00
摘要： The present invention is related to an intravaginal delivery system for the controlled release of drospirenone and an estrogen, optionally also comprising one or more therapeutically active or a health-promoting substance capable of giving and/or enhancing protection against bacterial and fungal infections, and/or enhancing protection against sexually transmitted diseases. The delivery system consists of one or more compartments, one of each comprising a core and a membrane encasing the core, said core and membrane essentially consisting of a same or different polymer composition, wherein at least one compartment comprises drospirenone ant at least one compartment which may be the same or different from the one comprising drospirenone, comprises an estrogen or a mixture of drospirenone and an estrogen, and wherein the membrane or the surface of the membrane or at least one of the cores comprises said therapeutically active or a health-promoting substance.
摘要翻译： 本发明涉及用于控制释放屈螺酮和雌激素的阴道内递送系统，任选地还包含一种或多种治疗活性或健康促进物质，其能够产生和/或增强针对细菌和真菌感染的保护和/ 或加强对性传播疾病的保护。 递送系统由一个或多个隔室组成，每个隔室中的一个包括芯和包围芯的膜，所述芯和膜基本上由相同或不同的聚合物组合物组成，其中至少一个隔室包含屈螺酮蚂蚁至少一个隔室， 可以与包含屈螺酮的那些相同或不同，包括雌激素或屈螺酮和雌激素的混合物，并且其中膜或膜的表面或至少一个核包含所述治疗活性或健康促进作用 物质。
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公开(公告)号：US20070275941A1
公开(公告)日：2007-11-29
申请号：US11749592
申请日：2007-05-16
申请人： Vladimir Hanes
发明人： Vladimir Hanes
CPC分类号： A61K31/565 , A61K31/566 , A61K31/585 , A61K2300/00
摘要： The present invention relates to the use of drospirenone for manufacture of a medicament for prevention of development of high blood pressure (>140/90 mm Hg) in a patient who is predisposed to develop high blood pressure. The present invention further refers to methods of prevention of development of high blood pressure (≧140/90 mm Hg) in a patient who is predisposed to develop high blood pressure by administering drospirenone to a patient in need of such prevention.
摘要翻译： 本发明涉及屈螺酮的用途，用于制造预防发展为高血压的患者中高血压（> 140 / 90mm Hg）发展的药物。 本发明还涉及通过向需要这种预防的患者施用屈螺酮来预防通过倾向于发展高血压的患者中高血压发展（> = 140 / 90mm Hg）的方法。
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公开(公告)号：US20100285097A1
公开(公告)日：2010-11-11
申请号：US12744227
申请日：2008-11-19
IPC分类号： A61F6/08 , A61K31/765 , A61K35/66 , A61K35/74 , A61K38/43 , A61K38/02 , A61K38/22 , A61K31/715 , A61K31/585 , A61P43/00 , A61P31/04 , A61P31/10
CPC分类号： A61K31/56 , A61K9/0036 , A61K31/565 , A61K31/585 , A61K2300/00
摘要： The present invention is related to an intravaginal delivery system for the controlled release of drospirenone and an estrogen, optionally also comprising one or more therapeutically active or a health-promoting substance capable of giving and/or enhancing protection against bacterial and fungal infections, and/or enhancing protection against sexually transmitted diseases. The delivery system consists of one or more compartments, one of each comprising a core and a membrane encasing the core, said core and membrane essentially consisting of a same or different polymer composition, wherein at least one compartment comprises drospirenone ant at least one compartment which may be the same or different from the one comprising drospirenone, comprises an estrogen or a mixture of drospirenone and an estrogen, and wherein the membrane or the surface of the membrane or at least one of the cores comprises said therapeutically active or a health-promoting substance.
摘要翻译： 本发明涉及用于控制释放屈螺酮和雌激素的阴道内递送系统，任选地还包含一种或多种治疗活性或健康促进物质，其能够产生和/或增强针对细菌和真菌感染的保护和/ 或加强对性传播疾病的保护。 递送系统由一个或多个隔室组成，每个隔室中的一个包括芯和包围芯的膜，所述芯和膜基本上由相同或不同的聚合物组合物组成，其中至少一个隔室包含屈螺酮蚂蚁至少一个隔室， 可以与包含屈螺酮的那些相同或不同，包括雌激素或屈螺酮和雌激素的混合物，并且其中膜或膜的表面或至少一个核包含所述治疗活性或健康促进作用 物质。
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