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    C1 inhibitor with short half-life transient treatment
    5.
    再颁专利
    C1 inhibitor with short half-life transient treatment 有权
    C1抑制剂短半衰期短暂治疗

    公开(公告)号：USRE43691E1

    公开(公告)日：2012-09-25

    申请号：US13157176

    申请日：2004-05-14

    申请人： Johannes Henricus Nuijens

    发明人： Johannes Henricus Nuijens

    IPC分类号： C07K14/81 ,  A61K38/48

    摘要： The present invention relates to the use of a C1 inhibitor (C1INH) with shorter half-life than plasma-derived C1INH for the preparation of a medicament for the transient treatment of an individual. It relates to both therapeutic and prophylactic treatment. The method of the invention allows for the administration of C1INH at certain therapeutic levels for a concise pre-determined time span. Pharmaceutical compositions based on C1INH with shorter half-lives may be used both in situations where transient treatment is merely and advantage. The advantage of the use according to the invention is that an individual is not exposed to C1INH for longer than required, since the levels of the C1INH more rapidly subsides after administration has stopped. In contrast, levels of plasma-derived C1INH would remain elevated for a prolonged period of time.

    摘要翻译： 本发明涉及具有比血浆来源的C1INH更短的半衰期的C1抑制剂（C1INH）用于制备用于个体的瞬时治疗的药物。 它涉及治疗和预防性治疗。 本发明的方法允许在某些治疗水平施用C1INH以获得简明的预定时间跨度。 具有较短半衰期的基于C1INH的药物组合物既可以用于短暂治疗仅仅是优势的情况。 根据本发明的用途的优点是个体不暴露于C1INH比所需时间更长，因为在给药后C1INH的水平更快地消退停止。 相比之下，血浆来源的C1INH的水平会持续升高一段较长的时间。

    C1 inhibitor with short half-life transient treatment
    6.
    发明授权
    C1 inhibitor with short half-life transient treatment 有权
    C1抑制剂短半衰期短暂治疗

    公开(公告)号：US07544853B2

    公开(公告)日：2009-06-09

    申请号：US10557026

    申请日：2004-05-14

    申请人： Johannes Henricus Nuijens

    发明人： Johannes Henricus Nuijens

    IPC分类号： C12P21/00 ,  A61K38/00

    CPC分类号： A61K38/57

    摘要： The present invention relates to the use of a C1 inhibitor (C1INH) with shorter half-life than plasma-derived C1INH for the preparation of a medicament for the transient treatment of an individual. It relates to both therapeutic and prophylactic treatment. The method of the invention allows for the administration of C1INH at certain therapeutic levels for a concise pre-determined time span. Pharmaceutical compositions based on C1INH with shorter half-lives may be used both in situations where transient treatment is merely and advantage. The advantage of the use according to the invention is that an individual is not exposed to C1INH for longer than required, since the levels of the C1INH more rapidly subsides after administration has stopped. In contrast, levels of plasma-derived C1INH would remain elevated for a prolonged period of time.

    摘要翻译： 本发明涉及具有比血浆来源的C1INH更短的半衰期的C1抑制剂（C1INH）用于制备用于个体的瞬时治疗的药物。 它涉及治疗和预防性治疗。 本发明的方法允许在某些治疗水平施用C1INH以获得简明的预定时间跨度。 具有较短半衰期的基于C1INH的药物组合物既可以用于短暂治疗仅仅是优势的情况。 根据本发明的用途的优点是个体不暴露于C1INH比所需时间更长，因为C1INH的水平在给药停止后更快速消退。 相比之下，血浆来源的C1INH的水平会持续升高一段较长的时间。