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公开(公告)号：US08557773B2
公开(公告)日：2013-10-15
申请号：US12990643
申请日：2009-04-29
CPC分类号： A61K38/37 , A61K38/36 , A61K38/363 , C07K14/75
摘要： The invention provides low-half life fibrinogen with reduced sialyation as a result of recombinant expression or enzymatic and chemical removal. The low-half life fibrinogen is useful in treating or effecting prophylaxis of bleeding particularly in situations of an acute nature in which a high initial dose and rapid decline to normal or below normal levels is desirable.
摘要翻译： 本发明提供低半衰期的纤维蛋白原，由于重组表达或酶促和化学去除而减少了唾液酸化。 低半衰期纤维蛋白原可用于治疗或预防出血，特别是在急性的情况下，其中初始剂量高，正常或正常水平急剧下降。
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公开(公告)号：US08071532B2
公开(公告)日：2011-12-06
申请号：US12158987
申请日：2006-12-19
申请人： Maurice Mannesse , Johannes Henricus Nuijens , Frank Pieper , Maria Grazia De Simoni , Gijsbertus Johannes Ziere
发明人： Maurice Mannesse , Johannes Henricus Nuijens , Frank Pieper , Maria Grazia De Simoni , Gijsbertus Johannes Ziere
IPC分类号： C07K14/00
摘要： The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ischemic period and reperfusion and therefore particularly useful for unforeseen occurrences of ischemic reperfusion such as e.g. a stroke.
摘要翻译： 本发明涉及C1抑制剂用于预防，减少和治疗缺血和再灌注损伤的治疗和预防用途。 本发明的C1抑制剂在缺血期和再灌注后施用时仍然是治疗有效的，因此特别可用于缺血再灌注的预期发生，例如， 中风。
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公开(公告)号：US20080305993A1
公开(公告)日：2008-12-11
申请号：US12158987
申请日：2006-12-19
申请人： Maurice Mannesse , Johannes Henricus Nuijens , Frank Pieper , Maria Grazia De Simoni , Gijsbertus Johannes Ziere
发明人： Maurice Mannesse , Johannes Henricus Nuijens , Frank Pieper , Maria Grazia De Simoni , Gijsbertus Johannes Ziere
摘要： The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ischemic period and reperfusion and therefore particularly useful for unforeseen occurrences of ischemic reperfusion such as e.g. a stroke.
摘要翻译： 本发明涉及C1抑制剂用于预防，减少和治疗缺血和再灌注损伤的治疗和预防用途。 本发明的C1抑制剂在缺血期和再灌注后施用时仍然是治疗有效的，因此特别可用于缺血再灌注的预期发生，例如， 中风。
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公开(公告)号：US5741957A
公开(公告)日：1998-04-21
申请号：US461333
申请日：1995-06-05
申请人： Herman A. Deboer , Rein Strijker , Herbert L. Heyneker , Gerard Platenburg , Sang He Lee , Frank Pieper , Paul J. A. Krimpenfort
发明人： Herman A. Deboer , Rein Strijker , Herbert L. Heyneker , Gerard Platenburg , Sang He Lee , Frank Pieper , Paul J. A. Krimpenfort
IPC分类号： A01K67/027 , A23C9/20 , C07K14/47 , C07K14/765 , C07K14/79 , C12N9/36 , C12N9/64 , C12N15/12 , C12N15/85 , C12N5/00 , C12N15/00 , C12P21/06
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A23C9/20 , C07K14/4732 , C07K14/765 , C07K14/79 , C12N15/85 , C12N9/2462 , C12N9/6464 , C12Y304/21069 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2227/101 , A01K2227/105 , A01K2267/01 , C12N2800/30 , C12N2830/008 , C12N2830/15 , C12N2830/42 , C12N2830/85 , C12N2840/44
摘要： A transgenic bovine is disclosed whose somatic and germ cells contain a transgene, wherein the transgene comprising a mammary gland specific promoter, a mammary gland specific enhancer, a DNA sequence encoding a signal sequence functional in bovine mammary gland secretory cells and a DNA sequence encoding a heterologous polypeptide of interest wherein the transgenic bovine expresses the transgene such that the polypeptide of interest is detectable in milk produced by the transgenic bovine.
摘要翻译： 公开了一种转基因牛，其体细胞和生殖细胞含有转基因，其中转基因包含乳腺特异性启动子，乳腺特异性增强子，编码牛乳腺分泌细胞中功能的信号序列的DNA序列和编码 感兴趣的异源多肽，其中转基因牛表达转基因，使得感兴趣的多肽在转基因牛产生的乳中是可检测的。
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公开(公告)号：US08415288B2
公开(公告)日：2013-04-09
申请号：US13271107
申请日：2011-10-11
申请人： Maurice Mannesse , Johannes Henricus Nuijens , Frank Pieper , Maria Grazia De Simoni , Gijsbertus Johannes Ziere
发明人： Maurice Mannesse , Johannes Henricus Nuijens , Frank Pieper , Maria Grazia De Simoni , Gijsbertus Johannes Ziere
IPC分类号： C07K14/00
摘要： The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ischemic period and reperfusion and therefore particularly useful for unforeseen occurrences of ischemic reperfusion such as e.g. a stroke.
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公开(公告)号：US20100305039A1
公开(公告)日：2010-12-02
申请号：US12268412
申请日：2008-11-10
申请人： Costas N. Karatzas , Frank Pieper , Ineke De Wit , Richard Berg , Gerard Platenburg , Paul David Toman
发明人： Costas N. Karatzas , Frank Pieper , Ineke De Wit , Richard Berg , Gerard Platenburg , Paul David Toman
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/101 , A01K2227/105 , A01K2267/01 , A23C9/20 , A23J1/20 , A23J3/06 , C07K14/78 , C07K2319/02
摘要： The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorporation into the mammals are also provided.
摘要翻译： 本发明提供能够将外源前胶原或胶原分泌到其牛奶中的转基因非人哺乳动物。 哺乳动物是健康的，能够以高水平产生前胶原或胶原蛋白，通常是三聚体形式。 还提供用于并入哺乳动物的合适的转基因。
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公开(公告)号：US20050223416A1
公开(公告)日：2005-10-06
申请号：US11087789
申请日：2005-03-22
申请人： Johannes Nuijens , Henricus Van Veen , Frank Pieper , Joris Heus
发明人： Johannes Nuijens , Henricus Van Veen , Frank Pieper , Joris Heus
IPC分类号： A01K67/027 , A23L1/305 , A61K38/00 , A61K38/55 , A61P9/00 , A61P9/10 , A61P17/02 , A61P29/00 , A61P31/04 , A61P37/06 , C07K14/81 , C12N15/09 , C12N15/85 , A61K38/54
CPC分类号： C07K14/8121 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2227/107 , A01K2267/01 , A23C2230/05 , A61K38/00 , C12N15/8509
摘要： The invention provides transgenic nonhuman mammals expressing C1 inhibitor in their milk. The C1 inhibitor is useful in treating patients with hereditary angioedema or patients requiring immunosuppression.
摘要翻译： 本发明提供了在其乳中表达C1抑制剂的转基因非人哺乳动物。 C1抑制剂可用于治疗遗传性血管性水肿患者或需要免疫抑制的患者。
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公开(公告)号：US06713662B1
公开(公告)日：2004-03-30
申请号：US08482173
申请日：1995-06-07
申请人： Costas N. Karatzas , Frank Pieper , Ineke De Wit , Richard Berg , Gerard Platenburg , Paul David Toman
发明人： Costas N. Karatzas , Frank Pieper , Ineke De Wit , Richard Berg , Gerard Platenburg , Paul David Toman
IPC分类号： C12P2100
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/101 , A01K2227/105 , A01K2267/01 , A23C9/20 , A23J1/20 , A23J3/06 , C07K14/78 , C07K2319/02
摘要： The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorporation into the mammals are also provided.
摘要翻译： 本发明提供能够将外源前胶原或胶原分泌到其牛奶中的转基因非人哺乳动物。 哺乳动物是健康的，能够以高水平产生前胶原或胶原蛋白，通常是三聚体形式。 还提供用于并入哺乳动物的合适的转基因。
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公开(公告)号：US5721367A
公开(公告)日：1998-02-24
申请号：US462986
申请日：1995-06-05
申请人： Robert M. Kay , Anton Berns , Paul Krimpenfort , Frank Pieper , Rein Strijker
发明人： Robert M. Kay , Anton Berns , Paul Krimpenfort , Frank Pieper , Rein Strijker
IPC分类号： A01K67/027 , C07K14/765 , C07K14/79 , C07K16/00 , C12N5/10 , C12N15/09 , C12N15/85 , C12N15/87 , C12N15/90 , C12N15/00 , C12N5/00 , C12P21/04 , C12P21/06
CPC分类号： A01K67/0275 , C07K14/765 , C07K14/79 , C07K16/00 , C12N15/85 , C12N15/87 , C12N15/907 , A01K2217/05 , C12N2800/206 , C12N2830/00 , C12N2830/85
摘要： The invention relates to methods for intracellularly producing DNA segments by homologous recombination of smaller overlapping DNA fragments and transgenic mammalian cells and transgenic non-human mammals produced by such methods.
摘要翻译： 本发明涉及通过较小的重叠DNA片段和转基因哺乳动物细胞以及通过这些方法产生的转基因非人哺乳动物的同源重组来细胞内产生DNA片段的方法。
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公开(公告)号：US5612205A
公开(公告)日：1997-03-18
申请号：US989002
申请日：1993-03-01
申请人： Robert M. Kay , Anton Berns , Paul Krimpenfort , Frank Pieper , Rein Strijker
发明人： Robert M. Kay , Anton Berns , Paul Krimpenfort , Frank Pieper , Rein Strijker
IPC分类号： A01K67/027 , C07K14/765 , C07K14/79 , C07K16/00 , C12N5/10 , C12N15/09 , C12N15/85 , C12N15/87 , C12N15/90 , C12N15/00
CPC分类号： A01K67/0275 , C07K14/765 , C07K14/79 , C07K16/00 , C12N15/85 , C12N15/87 , C12N15/907 , A01K2217/05 , C12N2800/206 , C12N2830/00 , C12N2830/85
摘要： The invention relates to methods for intracellularly producing DNA segments by homologous recombination of smaller overlapping DNA fragments and transgenic mammalian cells and transgenic non-human mammals produced by such methods.
摘要翻译： PCT No.PCT / US91 / 05917 Sec。 371日期1993年3月1日 102（e）1993年3月1日PCT PCT 1991年8月28日PCT公布。 出版物WO92 / 03917 日期：1992年3月19日本发明涉及通过较小重叠的DNA片段和转基因哺乳动物细胞与通过这些方法产生的转基因非人哺乳动物的同源重组来细胞内产生DNA片段的方法。
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