专利检索 ap:("Maurizio Acquasaliente" OR "Didier Houllemare" OR "Geoff Zhang" OR "Pulla Singam" OR "John Morris" OR "Kennan Marsh" OR "Martin Babcock" OR "John Pavlina" OR "Yi Shi" OR "Yuchuan Gong") AND inv:"John Pavlina" 第 1 页

1.

发明授权
Ritonavir bis-hydrochloride 有权
标题翻译：利托那韦双盐酸盐

公开(公告)号：US08598216B1

公开(公告)日：2013-12-03

申请号：US13328043

申请日：2011-12-16

申请人： Maurizio Acquasaliente , Didier Houllemare , Geoff Zhang , Pulla Singam , John Morris , Kennan Marsh , Martin Babcock , John Pavlina , Yi Shi , Yuchuan Gong

发明人： Maurizio Acquasaliente , Didier Houllemare , Geoff Zhang , Pulla Singam , John Morris , Kennan Marsh , Martin Babcock , John Pavlina , Yi Shi , Yuchuan Gong

IPC分类号： A61K31/426 , A61K31/41

CPC分类号： C07D277/18

摘要： The invention relates to ritonavir bis-hydrochloride, processes for the preparation of the ritonavir bis-hydrochloride, pharmaceutical compositions containing the ritonavir bis-hydrochloride and made from it, and methods of using the ritonavir bis-hydrochloride to inhibit HIV protease or enhance the pharmacokinetics of compounds which are metabolized by cytochrome P450 3A4.

摘要翻译： 本发明涉及利托那韦双盐酸盐，制备利托那韦双盐酸盐的方法，含有利托那韦双盐酸盐并由其制备的药物组合物，以及使用利托那韦双盐酸盐抑制HIV蛋白酶或增强药代动力学的方法的化合物，其被细胞色素P450 3A4代谢。