公开(公告)号：US08598216B1

公开(公告)日：2013-12-03

申请号：US13328043

申请日：2011-12-16

申请人： Maurizio Acquasaliente ,  Didier Houllemare ,  Geoff Zhang ,  Pulla Singam ,  John Morris ,  Kennan Marsh ,  Martin Babcock ,  John Pavlina ,  Yi Shi ,  Yuchuan Gong

发明人： Maurizio Acquasaliente ,  Didier Houllemare ,  Geoff Zhang ,  Pulla Singam ,  John Morris ,  Kennan Marsh ,  Martin Babcock ,  John Pavlina ,  Yi Shi ,  Yuchuan Gong

IPC分类号： A61K31/426 ,  A61K31/41

CPC分类号： C07D277/18

摘要： The invention relates to ritonavir bis-hydrochloride, processes for the preparation of the ritonavir bis-hydrochloride, pharmaceutical compositions containing the ritonavir bis-hydrochloride and made from it, and methods of using the ritonavir bis-hydrochloride to inhibit HIV protease or enhance the pharmacokinetics of compounds which are metabolized by cytochrome P450 3A4.

摘要翻译： 本发明涉及利托那韦双盐酸盐，制备利托那韦双盐酸盐的方法，含有利托那韦双盐酸盐并由其制备的药物组合物，以及使用利托那韦双盐酸盐抑制HIV蛋白酶或增强药代动力学的方法 的化合物，其被细胞色素P450 3A4代谢。

公开(公告)号：US20100278921A1

公开(公告)日：2010-11-04

申请号：US12770205

申请日：2010-04-29

申请人： Cristina M. Fischer ,  Rajeev Gokhale ,  Katherine Heemstra ,  David Hill ,  Kennan Marsh ,  Eric A. Schmitt ,  Yi Shi ,  Ping Tong ,  Deliang Zhou

发明人： Cristina M. Fischer ,  Rajeev Gokhale ,  Katherine Heemstra ,  David Hill ,  Kennan Marsh ,  Eric A. Schmitt ,  Yi Shi ,  Ping Tong ,  Deliang Zhou

IPC分类号： A61K31/5377 ,  A61K9/14 ,  A61P35/00

CPC分类号： A61K9/4866 ,  A61K9/1652 ,  A61K9/2054 ,  A61K31/5377

摘要： An orally deliverable pharmaceutical composition comprises (a) a pharmaceutically acceptable acid addition salt of ABT-263 in solid particulate form, and (b) a plurality of pharmaceutically acceptable excipients including at least a solid diluent and a solid disintegrant; wherein the salt is formed from more than one equivalent of acid per equivalent of ABT-263. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

摘要翻译： 可口服递送的药物组合物包含（a）固体颗粒形式的ABT-263的药学上可接受的酸加成盐，和（b）至少包含固体稀释剂和固体崩解剂的多种药学上可接受的赋形剂; 其中所述盐由每当量ABT-263的多于一当量的酸形成。 该组合物适合于有需要的受试者的口服给药，用于治疗以一种或多种抗凋亡Bcl-2家族蛋白（例如癌症）过表达为特征的疾病。

公开(公告)号：US20100297194A1

公开(公告)日：2010-11-25

申请号：US12770299

申请日：2010-04-29

申请人： Nathaniel Catron ,  Michael G. Fickes ,  Cristina M. Fischer ,  Rajeev Gokhale ,  Anthony R. Haight ,  Katherine Heemstra ,  David Hill ,  Martin Knobloch ,  Drazen Kostelac ,  Justin S. Lafountaine ,  Yanxia Li ,  Bernd Liepold ,  Kennan Marsh ,  Jonathan M. Miller ,  Claudia Packhaeuser ,  Yeshwant D. Sanzgiri ,  Eric A. Schmitt ,  Yi Shi ,  Norbert Steiger ,  Ping Tong ,  Huailiang Wu ,  Geoff G.Z. Zhang ,  Deliang Zhou

发明人： Nathaniel Catron ,  Michael G. Fickes ,  Cristina M. Fischer ,  Rajeev Gokhale ,  Anthony R. Haight ,  Katherine Heemstra ,  David Hill ,  Martin Knobloch ,  Drazen Kostelac ,  Justin S. Lafountaine ,  Yanxia Li ,  Bernd Liepold ,  Kennan Marsh ,  Jonathan M. Miller ,  Claudia Packhaeuser ,  Yeshwant D. Sanzgiri ,  Eric A. Schmitt ,  Yi Shi ,  Norbert Steiger ,  Ping Tong ,  Huailiang Wu ,  Geoff G.Z. Zhang ,  Deliang Zhou

IPC分类号： A61K31/5377 ,  A61K33/04 ,  A61K9/14 ,  A61P35/00

CPC分类号： A61K31/5377 ,  A61K9/08 ,  A61K9/10 ,  A61K9/146 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/4858 ,  A61K9/4866

摘要： An orally deliverable pharmaceutical composition comprises as a sole or first active ingredient a compound of Formula I defined herein or a pharmaceutically acceptable salt thereof, for example ABT-263 free base or ABT-263 bis-HCl salt, dispersed, in a free base equivalent amount of at least about 2.5% by weight of the composition, in a pharmaceutically acceptable carrier; wherein said active ingredient is in solid-state form and/or the composition further comprises, dispersed in the carrier, a pharmaceutically acceptable heavier-chalcogen antioxidant in an amount effective to inhibit oxidation of the active ingredient at a thioether linkage thereof. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

摘要翻译： 可口服递送的药物组合物包含作为唯一或第一活性成分的本文定义的式I化合物或其药学上可接受的盐，例如ABT-263游离碱或ABT-263双-HCl盐，以游离碱当量 至少约2.5重量％的组合物，在药学上可接受的载体中; 其中所述活性成分是固态形式和/或所述组合物还包含以有效抑制活性成分在其硫醚键的氧化的量分散在载体中的药学上可接受的较重硫族元素抗氧化剂。 该组合物适合于有需要的受试者的口服给药，用于治疗以一种或多种抗凋亡Bcl-2家族蛋白（例如癌症）过表达为特征的疾病。

公开(公告)号：US20150185727A1

公开(公告)日：2015-07-02

申请号：US14414903

申请日：2013-06-08

申请人： Yi SHI

发明人： Yi Shi

IPC分类号： G05B19/418

CPC分类号： G05B19/418 ,  G05B19/4148 ,  G05B19/4185 ,  G05B2219/31001 ,  G05B2219/31208 ,  G05B2219/31241 ,  G05B2219/31337 ,  G05B2219/32345 ,  Y02P90/04 ,  Y02P90/14 ,  Y02P90/18 ,  Y02P90/20 ,  Y02P90/26 ,  Y02P90/265

摘要： The invention provides an implementing method of cloud numerical control system. The method implements a numerical control system with functions of online error compensation, CAD/CAPP/CAM/CNC integrating and interactively cooperative assembling machining control. The cloud numerical control system includes a small cloud numerical control system a large cloud numerical control system. The small cloud numerical control system focuses on inside control of a single numerical control machining device and includes a cloud control core node, cloud measure and control subnodes and fine-tuning driving units. The large cloud numerical control system is based on the small cloud numerical control system and performs interactively cooperative machining between multiple numerical control machining devices for different workpieces to be assembled.

摘要翻译： 本发明提供了云数字控制系统的实现方法。 该方法实现了具有在线误差补偿，CAD / CAPP / CAM / CNC集成和交互协作组装加工控制功能的数控系统。 云数控系统包括一个小云数值控制系统，一个大型云数值控制系统。 小云数控系统侧重于单个数控加工设备的内部控制，包括云控核心节点，云测量控制子节点和微调驱动单元。 大型云数值控制系统基于小云数值控制系统，对不同工件要组装的多台数控加工装置之间进行交互式协同加工。

公开(公告)号：US20110215227A1

公开(公告)日：2011-09-08

申请号：US13126079

申请日：2010-02-10

申请人： Feng Yan ,  Rong Zhang ,  Yi Shi ,  Lin Pu ,  Yue Xu ,  Fuwei Wu ,  Xiaofeng Bo ,  Haoguang Xia

发明人： Feng Yan ,  Rong Zhang ,  Yi Shi ,  Lin Pu ,  Yue Xu ,  Fuwei Wu ,  Xiaofeng Bo ,  Haoguang Xia

IPC分类号： H01L31/112 ,  H03F3/08

CPC分类号： H01L27/14643 ,  H01L27/14614 ,  H01L31/1136

摘要： The present invention relates to a photosensitive detector with a composite dielectric gate MOSFET structure and its signal readout method. The MOSFET structure detector is formed on a p-type semiconductor substrate. N-type semiconductor regions locate on the two sides of the top part of the p-type semiconductor substrate to form a source and a drain. An underlying dielectric layer, a photo-electron storage layer, a top dielectric layer, and a control gate are stacked on the substrate in sequence. The top insulating dielectric layer can prevent the photoelectrons stored in the photo-electron storage layer from leaking into the control gate. The source and the drain are floating when photoelectrons are collected and injected into the photoelectron storing layer to be held therein. There is a transparent or semi-transparent window for detecting incident light forming on the substrate or gate surface. This invented detector has excellent scalability, basic compatibility with the flash memory fabricating technology, low leakage current, higher imaging speed than CCD, non-sensitivity to processing defects, larger dynamic range than other structures and higher accuracy of signal readout.

摘要翻译： 本发明涉及一种具有复合介电栅极MOSFET结构的光敏检测器及其信号读出方法。 MOSFET结构检测器形成在p型半导体衬底上。 N型半导体区域位于p型半导体衬底的顶部的两侧，以形成源极和漏极。 依次将基底电介质层，光电子存储层，顶部电介质层和控制栅极堆叠在基板上。 顶部绝缘介电层可以防止存储在光电子存储层中的光电子泄漏到控制栅极中。 当光电子被收集并注入到要保持在其中的光电子储存层时，源极和漏极是浮置的。 存在用于检测基板或栅极表面上的入射光形成的透明或半透明窗口。 本发明的检测器具有优异的可扩展性，与闪存制造技术的基本兼容性，低漏电流，比CCD更高的成像速度，对处理缺陷的灵敏度，对其他结构的动态范围更大，信号读出精度更高。

公开(公告)号：US06415386B1

公开(公告)日：2002-07-02

申请号：US09230890

申请日：1999-02-02

申请人： Yi Shi ,  Weizhi Tan

发明人： Yi Shi ,  Weizhi Tan

IPC分类号： G06F704

CPC分类号： G07C9/00309 ,  G07C2009/00412 ,  G07C2009/005 ,  G07C2009/00761 ,  G07C2009/00793

摘要： This invention provides an autonomous random dynamic cryptogram lock system which comprises a lock body and a key body. There are non-volatile memories in both the lock body and key body respectively and each memory stores a set of cryptogram corresponding. When unlocking the microprocessor in the lock body checks the cryptograms. If matching, the lock is unlocked, otherwise it gives up alarm. After unlocking, the microprocessor renews a set of the corresponding real random cryptogram in both memories for unlocking next time. It accomplishes one cryptoguard function every time.

摘要翻译： 本发明提供了一种自主的随机动态密码锁系统，其包括锁体和钥匙体。 锁体和钥匙体分别有非易失性存储器，每个存储器存储一组对应的密码。 当解锁锁体中的微处理器时，会检查密码。 如果匹配，锁定解锁，否则放弃报警。 解锁后，微处理器在两个存储器中更新一组相应的实际随机密码，以便下次解锁。 它每次都完成一个cryptoguard功能。

公开(公告)号：US20200254857A1

公开(公告)日：2020-08-13

申请号：US16785261

申请日：2020-02-07

申请人： Sunny Sun ,  Hardy Shen ,  Yi Shi

发明人： Sunny Sun ,  Hardy Shen ,  Yi Shi

IPC分类号： B60J7/043 ,  B60J7/057 ,  B60J7/19

摘要： An open roof assembly comprises a drive assembly having a slider member. The slider member comprising a coupling member, a first lever member coupled to a sunshade member and a second lever member coupled to a closure member. Each lever member comprises a mating member for coupling with the slider member and a locking lever for releasably engaging a respective locking recess. The slider member is sequentially couplable to one of the lever members. When the slider member is coupled to the first lever member, the sunshade member may be opened or closed by moving the slider member. When the slider member is coupled to the second lever member, the closure member may be opened or closed by moving the slider member.

公开(公告)号：US08962633B2

公开(公告)日：2015-02-24

申请号：US12118985

申请日：2008-05-12

申请人： Yi Shi ,  Theresa Freeman

发明人： Yi Shi ,  Theresa Freeman

IPC分类号： C07D239/70 ,  A61K31/517 ,  A61K31/4709 ,  A61K38/02 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/7088 ,  A61K31/56 ,  A61K38/17

CPC分类号： A61K38/17 ,  A61K31/4709 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/56 ,  A61K31/7088 ,  A61K38/02

摘要： The present invention provides compostions and methods useful for treating and preventing metabolic bone diseases and disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing metabolic bone diseases and disorders such as, for example osteoporosis, osteopenia and osteopenia related diseases and abnormal bone marrow.

摘要翻译： 本发明提供了用于通过抑制Lp-PLA2治疗和预防代谢性骨疾病和病症的组合物和方法。 组合物和方法可用于治疗和预防代谢性骨疾病和病症，例如骨质疏松症，骨质减少症和骨质减少症相关疾病和异常骨髓。

公开(公告)号：US08614299B2

公开(公告)日：2013-12-24

申请号：US13319710

申请日：2010-05-11

申请人： Nicolas Baurin ,  Francis Blanche ,  Beatrice Cameron ,  Marc Duchesne ,  Vincent Mikol ,  Souad Naimi ,  Laurent Pradier ,  Yi Shi

发明人： Nicolas Baurin ,  Francis Blanche ,  Beatrice Cameron ,  Marc Duchesne ,  Vincent Mikol ,  Souad Naimi ,  Laurent Pradier ,  Yi Shi

IPC分类号： C07K16/18 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K39/3955 ,  C07H21/04 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/92 ,  C12N15/63 ,  C12N2015/8518

摘要： The present application relates to humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide, and to the use of said antibodies in the field of Alzheimer's disease.

摘要翻译： 本申请涉及对原始原纤维形式的β-淀粉样蛋白肽特异性的人源化抗体以及所述抗体在阿尔茨海默氏病领域中的应用。

公开(公告)号：US20130171338A1

公开(公告)日：2013-07-04

申请号：US13819609

申请日：2011-03-31

申请人： Lijia Pan ,  Dongyuan Zhai ,  Yi Shi ,  Hao Qiu

发明人： Lijia Pan ,  Dongyuan Zhai ,  Yi Shi ,  Hao Qiu

IPC分类号： H01B1/12

CPC分类号： H01B1/12 ,  C08G61/124 ,  C08G61/126 ,  C08G73/0266 ,  C08J9/283 ,  C08J2201/0504 ,  C08J2205/022 ,  C08J2205/042 ,  C08J2207/00 ,  C08J2365/00 ,  C08K5/09 ,  C08K5/521 ,  H01G11/48 ,  H01M4/1399 ,  H01M4/606 ,  H01M4/608 ,  Y02E60/122 ,  Y02E60/13 ,  Y02P70/54 ,  C08L65/00 ,  C08L79/02

摘要： The present invention provides a conducting polymer, a synthesis method thereof, and an electroactive electrode covered with the said conducting polymer. The conducting polymer is synthesized as follows: use the polybasic acid as dopant and crosslinking agent, and polymerize monomers into conducting polymer hydrogel. The monomers are selected one or more from pyrrole or its derivatives, thiophene or its derivatives, aniline or its derivatives. The acid group of the polybasic acid contains phosphate or polybasic acid which contains at least two substituents per molecule selected from sulfate, nitrate or carboxylic in which the molecular weight of at least one acid group is no more than 800. The mole ratio of the acid group in polybasic acid to monomers of the conducting polymer is 1:12-12:1. The preparation applied in the invention is simple, and need not to import any impurity. The conducting polymer hydrogel has high ionic conductivity, super hydrophilicity, and good biocompatibility.

摘要翻译： 本发明提供一种导电聚合物，其合成方法和用所述导电聚合物覆盖的电活性电极。 导电聚合物如下合成：使用多元酸作为掺杂剂和交联剂，并将单体聚合成导电聚合物水凝胶。 单体选自吡咯或其衍生物，噻吩或其衍生物，苯胺或其衍生物中的一种或多种。 多元酸的酸基含有磷酸酯或多元酸，其含有至少两个选自硫酸根，硝酸根或羧酸的分子中的至少两个取代基，其中至少一个酸基的分子量不大于800。酸的摩尔比 多元酸与导电聚合物的单体组成为1：12-12：1。 本发明所用的制剂简单，不需要任何杂质。 导电聚合物水凝胶具有高离子电导率，超亲水性和良好的生物相容性。