-
公开(公告)号：US20070213353A1
公开(公告)日：2007-09-13
申请号：US11783495
申请日：2007-04-10
申请人： Mauro Marzi , Domenico Alloatti , Claudio Pisano , Maria Tinti , Loredana Vesci , Franco Zunino
发明人： Mauro Marzi , Domenico Alloatti , Claudio Pisano , Maria Tinti , Loredana Vesci , Franco Zunino
IPC分类号： A61K31/4745 , C07D491/14
CPC分类号： C07D491/22
摘要： Formula (I) compounds are described: (I) where the groups are as defined in the description here below, the racemic mixtures, their individual enantiomers, their individual diastereoisomers, their mixtures, and their pharmaceutically acceptable salts. Said compounds are topoisomerase I inhibitors.
摘要翻译： 描述了式（I）化合物：其中基团如下文所述的定义，外消旋混合物，其各自的对映异构体，其各自的非对映异构体，它们的混合物及其药学上可接受的盐。 所述化合物是拓扑异构酶I抑制剂。
-
公开(公告)号：US07498340B2
公开(公告)日：2009-03-03
申请号：US11783495
申请日：2007-04-10
申请人： Mauro Marzi , Domenico Alloatti , Claudio Pisano , Maria Ornella Tinti , Loredana Vesci , Franco Zunino
发明人： Mauro Marzi , Domenico Alloatti , Claudio Pisano , Maria Ornella Tinti , Loredana Vesci , Franco Zunino
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： C07D491/22
摘要： Formula (I) compounds are described: (I) where the groups are as defined in the description here below, the racemic mixtures, their individual enantiomers, their individual diastereoisomers, their mixtures, and their pharmaceutically acceptable salts. Said compounds are topoisomerase I inhibitors.
摘要翻译： 描述了式（I）化合物：其中基团如下文所述的定义，外消旋混合物，其各自的对映异构体，其各自的非对映异构体，它们的混合物及其药学上可接受的盐。 所述化合物是拓扑异构酶I抑制剂。
-
3.发明授权7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists 失效在20位缀合有整联蛋白拮抗剂的7-叔丁氧基亚氨基甲基喜树碱公开(公告)号：US07589099B2
公开(公告)日：2009-09-15
申请号：US11596016
申请日：2005-04-28
申请人： Claudio Pisano , Giuseppe Giannini , Loredana Vesci , Domenico Alloatti , Sergio Penco , Alma Dal Pozzo , Ni Ming Hong , Sabrina Dallavalle , Lucio Merlini , Maria Ornella Tinti , Franco Zunino
发明人： Claudio Pisano , Giuseppe Giannini , Loredana Vesci , Domenico Alloatti , Sergio Penco , Alma Dal Pozzo , Ni Ming Hong , Sabrina Dallavalle , Lucio Merlini , Maria Ornella Tinti , Franco Zunino
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： A61K47/64
摘要： Compounds of Formula (I) are described: in which the R1 group is as defined in the specification and includes the condensation of 7-t-butoxyiminomethylcamptothecin in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors αvβ3 and αvβ5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
摘要翻译： 描述式（I）的化合物：其中R 1基团如本说明书中所定义，并且包括位置20上的7-叔丁氧基亚氨基甲基喜树碱与含有RGD序列的环肽的缩合。 所述化合物赋予对整联蛋白受体alphavbeta3和alphavbeta5的高亲和力，并且在微摩尔浓度下对人肿瘤细胞系具有选择性细胞毒性活性。
-
4.发明授权Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents 失效缀合在位置7的喜树碱与环肽作为细胞抑制剂公开(公告)号：US07705012B2
公开(公告)日：2010-04-27
申请号：US11596015
申请日：2005-05-04
申请人： Claudio Pisano , Giuseppe Giannini , Maria Ornella Tinti , Loredana Vesci , Domenico Alloatti , Sergio Penco , Alma Dal Pozzo , Ni Minghong , Sabrina Dallavalle , Lucio Merlini , Franco Zunino
发明人： Claudio Pisano , Giuseppe Giannini , Maria Ornella Tinti , Loredana Vesci , Domenico Alloatti , Sergio Penco , Alma Dal Pozzo , Ni Minghong , Sabrina Dallavalle , Lucio Merlini , Franco Zunino
IPC分类号： A61K31/4745 , C07D491/22
摘要： Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors αvβ3 and αvβ5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
摘要翻译： 描述了式（I）的化合物，其中R 1基团如说明书中所定义，并且包括7位的喜树碱分子与含有RGD序列的环肽的缩合。 所述化合物对整联蛋白受体αv＆bgr 3和αv＆bgr 5具有高亲和力，并且在微摩尔浓度下对人肿瘤细胞系具有选择性细胞毒性活性。
-
5.发明申请Camptothecin Derivatives Conjugated in Position 20 with Integrin Antagonists 审中-公开喜树碱衍生物与20位整合素拮抗剂共轭公开(公告)号：US20070232639A1
公开(公告)日：2007-10-04
申请号：US11596189
申请日：2005-05-04
申请人： Claudio Pisano , Giuseppe Giannini , Maria Ornella Tinti , Loredana Vesci , Domenico Alloatti , Sergio Penco , Alma Dal Pozzo , Ni Minghong , Sabrina Dallavalle , Lucio Merlini , Franco Zunino
发明人： Claudio Pisano , Giuseppe Giannini , Maria Ornella Tinti , Loredana Vesci , Domenico Alloatti , Sergio Penco , Alma Dal Pozzo , Ni Minghong , Sabrina Dallavalle , Lucio Merlini , Franco Zunino
IPC分类号： A61K31/437 , A61K31/4375 , C07D405/14
CPC分类号： A61K47/64
摘要： Compounds or formula (I) are described, in which the R and R1 groups are as defined here below and include the condensation of the camptothecin molecule in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors αvβ3 and αvβ5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
摘要翻译： 描述了化合物或式（I），其中R和R 1个基团如下文所定义，并且包括20位的喜树碱分子与含有RGD序列的环肽的缩合。 所述化合物赋予对整联蛋白受体α和β5β5的高亲和力，并与 在微摩尔浓度下对人肿瘤细胞系的选择性细胞毒活性。
-
6.发明申请Camptothecins Conjugated in Position 7 to Cyclic Peptides as Cytostatic Agents 失效第7位缀合于环状肽作为细胞抑制剂的喜树碱公开(公告)号：US20080033003A1
公开(公告)日：2008-02-07
申请号：US11596015
申请日：2005-05-04
申请人： Claudio Pisano , Giuseppe Giannini , Maria Omella Tinti , Loredana Vesci , Domenico Alloatti , Sergio Penco , Alma Dal Pozzo , Ni Minghong , Sabrina Dallavalle , Lucio Merlini , Franco Zunino
发明人： Claudio Pisano , Giuseppe Giannini , Maria Omella Tinti , Loredana Vesci , Domenico Alloatti , Sergio Penco , Alma Dal Pozzo , Ni Minghong , Sabrina Dallavalle , Lucio Merlini , Franco Zunino
IPC分类号： A61K31/436 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04
摘要： Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors αvβ3 and αvβ5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
摘要翻译： 描述了式（I）的化合物，其中R 1 H 1基团如说明书中所定义，并且包括位置7上的喜树碱分子与含有RGD序列的环肽的缩合。 所述化合物赋予对整联蛋白受体α和β5β5的高亲和力，并与 在微摩尔浓度下对人肿瘤细胞系的选择性细胞毒活性。
-
公开(公告)号：US20080207729A1
公开(公告)日：2008-08-28
申请号：US11917065
申请日：2006-05-31
申请人： Claudio Pisano , Gianfranco Battistuzzi , Maria Di Marzo , Giuseppe Giannini , Mauro Marzi , Loredana Vesci , Franco Zunino
发明人： Claudio Pisano , Gianfranco Battistuzzi , Maria Di Marzo , Giuseppe Giannini , Mauro Marzi , Loredana Vesci , Franco Zunino
IPC分类号： A61K31/404 , A61P35/00 , C07D209/04
CPC分类号： C07D209/18
摘要： Indole derivatives of Formula (I+A) having antitumour and chemosensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumours.
摘要翻译： 描述了具有抗肿瘤和化学敏化活性的式（I + A）的吲哚衍生物。 还描述了含有上述化合物的药物组合物，用于治疗肿瘤。
-
8.发明申请Cinnamic, Phenylpropiolic and Phenylpropanoic Acid Derivatives Useful as Anti-Tumor Agents 失效肉桂酸，苯基丙酸和苯丙酸衍生物可用作抗肿瘤剂公开(公告)号：US20080194659A1
公开(公告)日：2008-08-14
申请号：US11917039
申请日：2006-05-31
申请人： Claudio Pisano , Gianfranco Battistuzzi , Maria Di Marzo , Giuseppe Giannini , Mauro Marzi , Loredana Vesci , Franco Zunino , Ricaardo Pezzi
发明人： Claudio Pisano , Gianfranco Battistuzzi , Maria Di Marzo , Giuseppe Giannini , Mauro Marzi , Loredana Vesci , Franco Zunino , Ricaardo Pezzi
IPC分类号： A61K31/42 , C07D261/06 , A61P35/04
CPC分类号： C07C251/52 , C07C251/36 , C07C251/40 , C07C251/48 , C07C251/60 , C07C251/86 , C07C313/28 , C07C381/00 , C07D209/08 , C07D295/088
摘要： Cinnamic and phenylpropiolic acid derivatives of formula (I) having antitumour and chemo sensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumours.
摘要翻译： 描述了具有抗肿瘤和化学敏化活性的式（I）的肉桂酸和苯基丙酸衍生物。 还描述了含有上述化合物的药物组合物，用于治疗肿瘤。
-
公开(公告)号：US08053460B2
公开(公告)日：2011-11-08
申请号：US11917065
申请日：2006-05-31
申请人： Claudio Pisano , Gianfranco Battistuzzi , Maria Di Marzo , Giuseppe Giannini , Mauro Marzi , Loredana Vesci , Franco Zunino
发明人： Claudio Pisano , Gianfranco Battistuzzi , Maria Di Marzo , Giuseppe Giannini , Mauro Marzi , Loredana Vesci , Franco Zunino
IPC分类号： A61K31/404 , C07D209/10
CPC分类号： C07D209/18
摘要： Indole derivatives of Formula (I+A) having antitumor and chemosensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumors.
摘要翻译： 描述了具有抗肿瘤和化学敏化活性的式（I + A）的吲哚衍生物。 还描述了含有上述化合物的药物组合物，用于治疗肿瘤。
-
10.发明授权Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumor agents 失效肉桂酸，苯丙酸和苯丙酸衍生物，可用作抗肿瘤剂公开(公告)号：US07816386B2
公开(公告)日：2010-10-19
申请号：US11917039
申请日：2006-05-31
申请人： Claudio Pisano , Gianfranco Battistuzzi , Maria Di Marzo , Giuseppe Giannini , Mauro Marzi , Loredana Vesci , Franco Zunino , Riccardo Pezzi
发明人： Claudio Pisano , Gianfranco Battistuzzi , Maria Di Marzo , Giuseppe Giannini , Mauro Marzi , Loredana Vesci , Franco Zunino , Riccardo Pezzi
IPC分类号： A61K31/42 , A61K31/165 , A61K31/404 , C07D209/04 , C07D261/06 , C07C233/01
CPC分类号： C07C251/52 , C07C251/36 , C07C251/40 , C07C251/48 , C07C251/60 , C07C251/86 , C07C313/28 , C07C381/00 , C07D209/08 , C07D295/088
摘要： Cinnamic and phenylpropiolic acid derivatives of formula (I) having antitumour and chemo sensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumours.
摘要翻译： 描述了具有抗肿瘤和化学敏化活性的式（I）的肉桂酸和苯基丙酸衍生物。 还描述了含有上述化合物的药物组合物，用于治疗肿瘤。
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.025 秒)
