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    Novel benzothienyl amino (propyl and butyl) ketones
    2.
    发明授权
    Novel benzothienyl amino (propyl and butyl) ketones 失效
    新型苯并噻吩基氨基（丙基和丁基）酮

    公开(公告)号：US4249014A

    公开(公告)日：1981-02-03

    申请号：US76872

    申请日：1979-09-19

    申请人： Max F. Robba ,  Michel Aurousseau

    发明人： Max F. Robba ,  Michel Aurousseau

    IPC分类号： A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/445 ,  A61K31/535 ,  A61K31/55 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P25/04 ,  A61P29/00 ,  C07D333/58

    CPC分类号： C07D333/58 ,  Y10S514/822 ,  Y10S514/929

    摘要： Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are alkyl having one to 4 carbon atoms, allyl or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, RX is an inorganic acid, organic acid or an alkyl bromide or iodide, m is 3 or 4, and n is zero or one. The compounds are prepared by (1) reacting benzothienyl-lithium with ##STR3## followed by hydrolysis, or (2) when the substituent is located at the 2 position of the benzothienyl group, by reacting benzothiophene with ##STR4## followed by reaction with ##STR5## The compounds possess bloodplaque aggregation, spasmolytic, analgesic, anti-inflammatory and coronary, cerebral and peripheral vaso-dilatory properties.

    摘要翻译： 具有式的化合物，其中R 1和R 2是具有1至4个碳原子的烷基，烯丙基或者R 3是吡咯烷子基，哌啶子基，全氢氮杂环或吗啉代，RX是无机酸，有机酸或烷基溴或碘，m 是3或4，n是0或1。 化合物通过以下方法制备：（1）使苯并噻吩基锂与“IMAGE”反应，然后水解，或（2）当取代基位于苯并噻吩基的2位时，通过苯并噻吩与“IMAGE”反应， 该化合物具有血斑聚集，解痉，止痛，消炎和冠状动脉，脑和周围血管舒张性。

    Novel benzothienyl amino (propyl and butyl) ketones, a method of preparation thereof and their application to therapeutics
    3.
    发明授权
    Novel benzothienyl amino (propyl and butyl) ketones, a method of preparation thereof and their application to therapeutics 失效
    新的苯并噻吩基氨基（丙基和丁基）酮，其制备方法及其在治疗中的应用

    公开(公告)号：US4186136A

    公开(公告)日：1980-01-29

    申请号：US672109

    申请日：1976-03-31

    申请人： Max F. Robba ,  Michel Aurousseau

    发明人： Max F. Robba ,  Michel Aurousseau

    IPC分类号： A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/445 ,  A61K31/535 ,  A61K31/55 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P25/04 ,  A61P29/00 ,  C07D333/58 ,  A01N9/00 ,  A01N9/22

    CPC分类号： C07D333/58 ,  Y10S514/822 ,  Y10S514/929

    摘要： Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are alkyl having one to 4 carbon atoms, allyl or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, RX is an inorganic acid, organic acid or an alkyl bromide or iodide, m is 3 or 4, and n is zero or one. The compounds are prepared by (1) reacting benzothienyl-lithium with ##STR3## followed by hydrolysis, or (2) when the substituent is located at the 2 position of the benzothienyl group, by reacting benzothiophene with ##STR4## followed by reaction with ##STR5## The compounds possess blood-plaque aggregation, spasmolytic, analgesic, anti-inflammatory and coronary, cerebral and peripheral vaso-dilatory properties.

    摘要翻译： 具有式的化合物，其中R 1和R 2是具有1至4个碳原子的烷基，烯丙基或者R 3是吡咯烷子基，哌啶子基，全氢氮杂环或吗啉代，RX是无机酸，有机酸或烷基溴或碘，m 是3或4，n是0或1。 化合物通过以下方法制备：（1）使苯并噻吩基锂与“IMAGE”反应，然后水解，或（2）当取代基位于苯并噻吩基的2位时，通过苯并噻吩与“IMAGE”反应， 该化合物具有血斑聚集，解痉，镇痛，抗炎和冠状动脉，脑和周围血管扩张性质。