公开(公告)号：US10913710B2

公开(公告)日：2021-02-09

申请号：US16477233

申请日：2018-01-11

申请人： Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.

发明人： Herbert Waldmann ,  Pablo Antonio Martin-Gago ,  Sandip Murarka ,  Christian Klein ,  Philippe Bastiaens ,  Alfred Wittinghofer ,  Eyad Kalawy Fansa

IPC分类号： C07C311/16 ,  C07D221/00 ,  C07D239/26 ,  C07D241/04 ,  C07D401/12 ,  C07D405/14 ,  C07D493/10

摘要： The present invention relates to novel substituted benzene disulfonamides, as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said substituted benzene disulfonamides are binding to the prenyl binding pocket of PDE6δ and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDE6δ to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.