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公开(公告)号：US20220311383A1
公开(公告)日：2022-09-29
申请号：US17618064
申请日：2019-06-12
申请人： Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V. , Board of Trustees Michigan State University
发明人： Xin YU , Chunqi QIAN
摘要： The multi-modal imaging system, in particular for brain imaging, comprising a pump signal generator which emits at least one pump signal in the radio frequency (RF)-range with a first power P1 and a second power P2, a wireless detection unit, which comprises at least one parametric resonator circuit with multiple resonance modes, wherein the at least one parametric resonator circuit comprises at least two varactors, at least one capacitor and at least one inductance, wherein, in a first detection mode, the pump signal, having a first power P1, induces a first pump current in the at least one parametric resonator circuit, wherein the at least one parametric resonator circuit is operated below its oscillation threshold and generates a first output signal by amplifying a first input signal, which is provided due to a magnetic-resonance (MR) measurement, wherein an external receiving device receives the first output signal, wherein, in a second detection mode, the pump signal, having a second power P2, induces a second pump current in the at least one parametric resonator circuit, wherein the at least one parametric resonator circuit is operated above its oscillation threshold and generates a second output signal, wherein the second output signal is modulated with a second input signal, wherein the second input signal is provided by at least one neuronal probe device, connected to the at least one parametric resonator circuit, wherein the external receiving device receives the second output signal.
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公开(公告)号：US10913710B2
公开(公告)日：2021-02-09
申请号：US16477233
申请日：2018-01-11
发明人： Herbert Waldmann , Pablo Antonio Martin-Gago , Sandip Murarka , Christian Klein , Philippe Bastiaens , Alfred Wittinghofer , Eyad Kalawy Fansa
IPC分类号： C07C311/16 , C07D221/00 , C07D239/26 , C07D241/04 , C07D401/12 , C07D405/14 , C07D493/10
摘要： The present invention relates to novel substituted benzene disulfonamides, as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said substituted benzene disulfonamides are binding to the prenyl binding pocket of PDE6δ and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDE6δ to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.
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公开(公告)号：US20200299693A1
公开(公告)日：2020-09-24
申请号：US16805072
申请日：2020-02-28
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , Whitehead Institute for Biomedical Research , UNIVERSITY OF MASSACHUSETTS
IPC分类号： C12N15/113 , A61K48/00 , C12N15/10 , C12N15/11
摘要： Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3′ ends mediate efficient target RNA cleavage in the lysate, and the cleavage site is located near the center of the region spanned by the guiding siRNA. Furthermore, we provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNP complex.
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公开(公告)号：US10435373B2
公开(公告)日：2019-10-08
申请号：US16054416
申请日：2018-08-03
申请人： LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN , MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.
发明人： Armin Giese , Uwe Bertsch , Hans Kretzschmar , Matthias Habeck , Thomas Hirschberger , Paul Tavan , Christian Griesinger , Andrei Leonov , Sergey Ryazanov , Petra Frick née Weber , Markus Geissen , Martin H. Groschup , Jens Wagner
IPC分类号： C07D231/12 , C07D207/333 , C07D231/06 , C07D233/64 , C07D261/08 , C07D271/06 , C07D405/04 , C07D413/04 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/42 , A61K31/4245 , G01N33/68
摘要： The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed.
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公开(公告)号：US10359398B2
公开(公告)日：2019-07-23
申请号：US15757019
申请日：2015-09-03
发明人： Johanna Hofmann , Heung Sik Hahm , Peter Seeberger , Kevin Pagel
摘要： The present invention relates to a method for determining in an expedient manner and with minimal sample consumption the structure of an unknown carbohydrate by using ion mobility-mass spectrometry (IM-MS) in negative ionization mode and fragmentation and a database containing structures of carbohydrates and/or of the fragments of the negative ions of carbohydrates, and for each of the structures of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the negative ion thereof, and for each of the structures of the fragments of the negative ions of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the fragment of the negative ion of the target carbohydrate.
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公开(公告)号：US20190119313A1
公开(公告)日：2019-04-25
申请号：US16094458
申请日：2017-04-18
发明人： Peter H. Seeberger , Claney Lebev Pereira , Sharavathi Guddehalli Parameswarappa , Adam Daniel James Calow , Petra Menova , Ju Yuel Baek
摘要： The present invention relates to the preparation of a synthetic tetrasaccharide, hexasaccharide and octasaccharide representing part of the repeating unit of the Streptococcus pneumoniae type 3 capsular polysaccharide as well as conjugates thereof. Said conjugates are particularly useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically of diseases associated with Streptococcus pneumoniae type 3. The disclosed synthetic method has the huge advantages over the state of the art synthetic methods that intermediate products are crystalline, coupling reaction yields are higher, less reaction steps are required and purification of intermediate products is easier.
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公开(公告)号：US20190052892A1
公开(公告)日：2019-02-14
申请号：US16159866
申请日：2018-10-15
IPC分类号： H04N19/50 , H04N19/59 , H04N19/98 , H04N19/33 , H04N19/187 , H04N19/184 , H04N19/136 , H04N19/63 , H04N19/105 , H04N19/124 , H04N19/186
摘要： A method for encoding high dynamic range (HDR) images involves providing a lower dynamic range (LDR) image, generating a prediction function for estimating the values for pixels in the HDR image based on the values of corresponding pixels in the LDR image, and obtaining a residual frame based on differences between the pixel values of the HDR image and estimated pixel values. The LDR image, prediction function and residual frame can all be encoded in data from which either the LDR image of HDR image can be recreated.
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公开(公告)号：US10182999B2
公开(公告)日：2019-01-22
申请号：US15505132
申请日：2015-08-18
摘要： The present invention relates to glycolic acid or a pharmaceutically acceptable salt or ester thereof for use in the treatment or prevention of male infertility. The present invention also relates to an ex vivo method for increasing the mobility of spermatozoa comprising contacting glycolic acid or a pharmaceutically acceptable salt or ester thereof with spermatozoa.
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公开(公告)号：US20180116759A1
公开(公告)日：2018-05-03
申请号：US15728794
申请日：2017-10-10
CPC分类号： A61B90/50 , A61B5/0071 , A61B5/0084 , A61B5/055 , A61B5/061 , A61B34/20 , A61B34/30 , A61B90/39 , A61B2034/2046 , A61B2034/2055 , A61B2090/0811 , B25J9/04 , G01R33/286 , G01R33/4806 , G01R33/4808
摘要： A positioning system for an imaging device, in particular a MR imaging device to position an insertion element on or in the body of a subject, in particular an animal, wherein the imaging device comprises a bore, in which the subject is received, wherein the positioning system comprises a robot which can be at least partially arranged in the bore of the imaging device and comprises a holding element to hold the insertion element; wherein the robot further comprises at least one actuator acting on the holding element, such that an end portion of the insertion element is movable, wherein said at least one actuator is arranged with a distance D from the bore to minimize magnetic and/or electromagnetic interferences between the imaging device and the at least one actuator and said first actuator is coupled to the holding element in a form-fit- and/or a force-fit-manner.
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![Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders](/abs-image/US/2018/03/13/US09914732B2/abs.jpg.150x150.jpg)
公开(公告)号：US09914732B2
公开(公告)日：2018-03-13
申请号：US15113529
申请日：2015-01-26
IPC分类号： C07D471/08 , A61K31/551 , A61K31/635 , A61K45/06 , C07D211/60 , C07D303/36
CPC分类号： C07D471/08 , A61K31/551 , A61K31/635 , A61K45/06 , C07D211/60 , C07D303/36
摘要： The present invention relates to diazabicyclo[4.3.1]decane derivatives, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said diazabicyclo[4.3.1]decane derivatives can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions.
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