公开(公告)号：US06231890B1

公开(公告)日：2001-05-15

申请号：US09171631

申请日：1998-10-22

申请人： Mayumi Naito ,  Hiroshi Nakano ,  Kazuo Hasegawa ,  Toshiaki Nakajima ,  Ichiro Okudaira ,  Kenji Tsunoda

发明人： Mayumi Naito ,  Hiroshi Nakano ,  Kazuo Hasegawa ,  Toshiaki Nakajima ,  Ichiro Okudaira ,  Kenji Tsunoda

IPC分类号： A61K914

CPC分类号： A61K9/0095

摘要： A suspension of a sparingly water-soluble acidic drug, especially, a nonsteroidal anti-inflammatory analgesic agent, which is stable for a prolonged period of time and is highly dissolvable, and a process for simply and easily producing the suspension. This suspension has a pH value of 2 to 5 and comprises a sparingly water-soluble acidic drug whose average particle size ranges from 1 to 15 &mgr;m, a polyglycerol fatty acid ester, a water-soluble polyhydric alcohol and water, optionally, together with an inorganic powder having an average particle size of 1 to 15 &mgr;m. This process is characterized by carrying out pulverization and dispersion of a sparingly water-soluble acid drug, a polyglycerol fatty acid ester, a water-soluble polyhydric alcohol and water by means of a pulverizer comprising a main shaft adapted to rotate in a casing and a plurality of layshafts adapted to revolve in relationship interlocked with the rotation of the main shaft, each of the layshafts being fitted with a multiplicity of annular griding media.

摘要翻译： 微溶水性酸性药物，特别是长时间稳定且非常可溶性的非甾体抗炎止痛剂的悬浮液，以及简单且容易地制备悬浮液的方法。 该悬浮液的pH值为2〜5，并且包含平均粒径为1〜15μm的微溶水性酸性药物，聚甘油脂肪酸酯，水溶性多元醇和水，任选地与 平均粒径为1〜15μm的无机粉末。 该方法的特征在于通过粉碎机进行微水溶性酸性药物，聚甘油脂肪酸酯，水溶性多元醇和水的粉碎和分散，所述粉碎机包括适于在壳体内旋转的主轴和 多个副轴适于以与主轴的旋转互锁的关系旋转，每个副轴装配有多个环形磨盘。