公开(公告)号：US20230405042A1

公开(公告)日：2023-12-21

申请号：US18198154

申请日：2023-05-16

Applicant: McMaster University

Inventor： Jonathan Schertzer ,  Fernando Forato Anhe ,  Han Fang

IPC: A61K31/765 ,  A61K38/44 ,  A61K38/26 ,  A61K31/155 ,  A61K35/741 ,  A61P3/10

CPC classification number: A61K31/765 ,  A61K38/443 ,  A61P3/10 ,  A61K31/155 ,  A61K35/741 ,  A61K38/26

Abstract: The present application relates to methods of lowering at least one of blood glucose, liver fat, liver glycogen, insulin or insulin resistance in a mammal, for example, mammals who are obese, or have metabolic disease, fatty liver disease, pre-diabetes or type 2 diabetes. In an embodiment, a method comprises administering to a mammal a polymer comprising L-lactate monomer, or a functionally equivalent derivative or fragment thereof, which inhibits or at least reduces D-lactate transport across the intestinal barrier. Compositions useful in the methods are also provided.