公开(公告)号：US20230406899A1

公开(公告)日：2023-12-21

申请号：US18211970

申请日：2023-06-20

Applicant: McMaster University

Inventor： Ishac Nazy ,  Donald Arnold ,  John Kelton ,  Angela Huynh ,  Mercy Charity Daka

IPC: C07K14/52 ,  G01N33/68 ,  G01N33/564

CPC classification number: C07K14/522 ,  G01N33/6863 ,  G01N2333/522 ,  G01N2800/226 ,  G01N33/564

Abstract: Described are mutant Platelet Factor 4 (PF4) proteins that exhibit different binding affinities to vaccine induced immune thrombotic thrombocytopenia (VITT) antibodies or non-heparin-induced thrombocytopenia (non-HIT) antibodies relative to heparin-induced thrombocytopenia (HIT) antibodies. Also provided herein are methods for differentiating between VITT, HIT, and/or non-HIT in subjects suspected of having VITT, HIT, or non-HIT.