公开(公告)号：US20220348936A1

公开(公告)日：2022-11-03

申请号：US17753119

申请日：2020-09-16

Applicant: McMaster University

Inventor： Jonathan Bramson ,  Phillip Marvyn

IPC: C12N15/62 ,  C07K14/705 ,  C07K14/715 ,  C12N5/0783

Abstract: Described herein is a chimeric costimulatory receptor (CCR) molecule having an extracellular domain of a Tumor Necrosis Factor Superfamily member, a transmembrane domain and a cytosolic costimulatory signaling domain from a Tumor Necrosis Factor Receptor Superfamily member is provided. Also provided are pharmaceutical compositions having a T cell expressing CCR and methods and uses of such T cells to treat cancers.