公开(公告)号：US11578119B2

公开(公告)日：2023-02-14

申请号：US17340622

申请日：2021-06-07

Applicant: MedImmune, LLC ,  Humabs BioMed SA

Inventor： Christine Tkaczyk ,  Bret Sellman ,  Qun Du ,  Melissa Damschroder ,  Davide Corti ,  Andrea Minola

IPC: C07K16/12 ,  A61P31/04 ,  G01N33/569

Abstract: The present disclosure is directed to leukotoxin-binding antibodies and antigen-binding fragments thereof. The antibodies and fragments can be used, for example, to detect leukotoxin and/or in methods of treating and preventing Staphylococcus aureus infections.

公开(公告)号：US11059884B2

公开(公告)日：2021-07-13

申请号：US16596445

申请日：2019-10-08

Applicant: MedImmune, LLC ,  Humabs BioMed SA

Inventor： Christine Tkaczyk ,  Bret Sellman ,  Qun Du ,  Melissa Damschroder ,  Davide Corti ,  Andrea Minola

IPC: C07K16/12 ,  A61P31/04 ,  G01N33/569

Abstract: The present disclosure is directed to leukotoxin-binding antibodies and antigen-binding fragments thereof. The antibodies and fragments can be used, for example, to detect leukotoxin and/or in methods of treating and preventing Staphylococcus aureus infections.

公开(公告)号：US11447543B2

公开(公告)日：2022-09-20

申请号：US16925129

申请日：2020-07-09

Applicant: MedImmune, LLC

Inventor： Bret Sellman ,  Christine Tkaczyk ,  Partha S. Chowdhury ,  Lei Hua ,  Peter Pavlik ,  Rebecca Buonpane ,  Chew-Shun Chang

IPC: C07K16/12 ,  A61K39/40 ,  A61K45/06 ,  G01N33/569 ,  A61K39/00

Abstract: Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.

公开(公告)号：US20150291685A1

公开(公告)日：2015-10-15

申请号：US14440748

申请日：2013-11-06

Applicant: MEDIMMUNE, LLC

Inventor： Bret Sellman ,  Christine Tkaczyk ,  Partha S. Chowdhury ,  Lei Hua ,  Peter Pavlik ,  Rebecca Buonpane ,  Chew-Shun Chang

IPC: C07K16/12 ,  A61K45/06 ,  G01N33/569 ,  A61K39/40

CPC classification number: C07K16/1271 ,  A61K39/40 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56938

Abstract: Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.

Abstract translation: 公开了针对金黄色葡萄球菌（金黄色葡萄球菌）表面决定簇抗原和分泌毒素的抗体及其抗原结合片段。 还提供了使用抗体及其抗原结合片段检测，诊断和处理金黄色葡萄球菌的方法。

公开(公告)号：US11155606B2

公开(公告)日：2021-10-26

申请号：US16521223

申请日：2019-07-24

Applicant: MedImmune, LLC ,  Humabs BioMed SA

Inventor： Christine Tkaczyk ,  Bret Sellman ,  Martin Borrok, III ,  Davide Corti ,  Andrea Minola

IPC: C07K16/12

Abstract: The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to a Staphylococcus aureus clumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody. The disclosure also is directed to methods of treating a Staphylococcus aureus infection by administering the anti-ClfA monoclonal antibody alone, or in combination with a monoclonal antibody that specifically binds to S. aureus alpha toxin (AT) protein to a subject. Bispecific monoclonal antibodies that specifically bind to both ClfA and AT and methods of using the same also are provided.

公开(公告)号：US10730934B2

公开(公告)日：2020-08-04

申请号：US15880157

申请日：2018-01-25

Applicant: MEDIMMUNE, LLC

Inventor： Bret Sellman ,  Christine Tkaczyk ,  Partha S. Chowdhury ,  Lei Hua ,  Peter Pavlik ,  Rebecca Buonpane ,  Chew-Shun Chang

IPC: C07K16/12 ,  G01N33/569 ,  A61K39/40 ,  A61K45/06 ,  A61K39/00

Abstract: Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.

公开(公告)号：US10457724B2

公开(公告)日：2019-10-29

申请号：US15845701

申请日：2017-12-18

Applicant: MedImmune, LLC

Inventor： Brett R. Sellman ,  Christine Tkaczyk ,  Melissa Hamilton ,  Lei Hua

IPC: A61K39/085 ,  A61K49/00 ,  A61K39/12 ,  C07K16/12 ,  A61K39/00

Abstract: The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating S. aureus-associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (anti-AT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus associated pneumonia in an immunocompromised mammalian subject.

公开(公告)号：US11970527B2

公开(公告)日：2024-04-30

申请号：US17483162

申请日：2021-09-23

Applicant: MedImmune, LLC ,  Humabs BioMed SA

Inventor： Christine Tkaczyk ,  Bret Sellman ,  Martin Borrok, III ,  Davide Corti ,  Andrea Minola

IPC: C07K16/12

CPC classification number: C07K16/1271 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515

Abstract: The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to a Staphylococcus aureus clumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody. The disclosure also is directed to methods of treating a Staphylococcus aureus infection by administering the anti-ClfA monoclonal antibody alone, or in combination with a monoclonal antibody that specifically binds to S. aureus alpha toxin (AT) protein to a subject. Bispecific monoclonal antibodies that specifically bind to both ClfA and AT and methods of using the same also are provided.

公开(公告)号：US11168133B2

公开(公告)日：2021-11-09

申请号：US16596388

申请日：2019-10-08

Applicant: MedImmune, LLC

Inventor： Christine Tkaczyk ,  Bret Sellman ,  Qun Du ,  Melissa Damschroder ,  Taylor Cohen

IPC: C07K16/12 ,  A61K38/00

Abstract: The present disclosure is directed to anti-Staphylococcus aureus antibody combinations including combinations of antibodies that bind to S. aureus alpha toxin (AT) protein, clumping factor A protein (ClfA), and/or at least one leukotoxin protein. Methods of treating and preventing infections comprising administering the antibody combinations are also provided herein.

公开(公告)号：US10759849B2

公开(公告)日：2020-09-01

申请号：US16599595

申请日：2019-10-11

Applicant: MedImmune, LLC

Inventor： Brett R. Sellman ,  Christine Tkaczyk ,  Melissa Hamilton ,  Lei Hua

IPC: A61K49/00 ,  A61K39/085 ,  A61K39/00 ,  C07K16/12

Abstract: The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating S. aureus-associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (anti-AT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus associated pneumonia in an immunocompromised mammalian subject.