公开(公告)号：US10000553B2

公开(公告)日：2018-06-19

申请号：US14347016

申请日：2012-10-10

Applicant: MedImmune, LLC

Inventor： Anthony Coyle ,  Manuel Baca ,  Thomas Thisted ,  Stacey Drabic ,  Luba Grinberg ,  Shabazz Novarra ,  Vaheh Oganesyan ,  Ronald Herbst ,  David Kenneth Spencer

IPC: C07K14/78 ,  C07K16/28 ,  A61K38/39

CPC classification number: C07K14/78 ,  A61K38/39 ,  C07K16/2875 ,  C07K2318/20 ,  C07K2319/21 ,  C07K2319/30 ,  C07K2319/31

Abstract: The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.