公开(公告)号：US09527927B2

公开(公告)日：2016-12-27

申请号：US14366582

申请日：2012-12-18

Applicant: MedImmune, LLC

Inventor： Partha S. Chowdhury ,  Vaheh Oganesyan ,  Yariv Mazor ,  Nazzareno Dimasi

IPC: C07K16/46 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32

CPC classification number: C07K16/468 ,  C07K16/248 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94

Abstract: The technology relates in part to engineered antibodies. In particular, multispecific engineered antibodies. Such antibodies can be utilized for diagnostic and therapeutic applications in some aspects.

Abstract translation: 该技术部分涉及工程抗体。 特别是多特异性工程化抗体。 这些抗体可用于某些方面的诊断和治疗应用。

公开(公告)号：US10000553B2

公开(公告)日：2018-06-19

申请号：US14347016

申请日：2012-10-10

Applicant: MedImmune, LLC

Inventor： Anthony Coyle ,  Manuel Baca ,  Thomas Thisted ,  Stacey Drabic ,  Luba Grinberg ,  Shabazz Novarra ,  Vaheh Oganesyan ,  Ronald Herbst ,  David Kenneth Spencer

IPC: C07K14/78 ,  C07K16/28 ,  A61K38/39

CPC classification number: C07K14/78 ,  A61K38/39 ,  C07K16/2875 ,  C07K2318/20 ,  C07K2319/21 ,  C07K2319/30 ,  C07K2319/31

Abstract: The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.

公开(公告)号：US20140348839A1

公开(公告)日：2014-11-27

申请号：US14366582

申请日：2012-12-18

Applicant: MedImmune, LLC

Inventor： Partha S. Chowdhury ,  Vaheh Oganesyan ,  Yariv Mazor ,  Nazzareno Dimasi

IPC: C07K16/46

CPC classification number: C07K16/468 ,  C07K16/248 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94

Abstract: The technology relates in part to engineered antibodies. In particular, multispecific engineered antibodies. Such antibodies can be utilized for diagnostic and therapeutic applications in some aspects.

Abstract translation: 该技术部分涉及工程抗体。 特别是多特异性工程化抗体。 这些抗体可用于某些方面的诊断和治疗应用。