公开(公告)号：US20250152332A1

公开(公告)日：2025-05-15

申请号：US18945912

申请日：2024-11-13

Applicant: Medtronic, Inc.

Inventor： Jonathan T. Goodman ,  Shanthi John Lawrence ,  Charlene X. Yuan ,  Daniel R. Lexcen

IPC: A61F2/12 ,  A61F2/00

Abstract: An implantable medical device includes a mesh substrate. A first coating that covers at least a portion of the substrate. The first coating includes a first biodegradable or bioresorbable polymer. The first coating has a chemotherapeutic agent dispersed in the first polymer such that the first polymer releases the agent as the first polymer degrades. A second coating covers at least a portion of the first coating. The second coating includes a second biodegradable or bioresorbable polymer. The second coating has an antibiotic agent dispersed in the second polymer such that the second polymer releases the agent as the second polymer degrades. The first coating is configured to release the chemotherapeutic agent over about 10-180 days and the second coating is configured to release the antibiotic agent over about 3-10 days.

公开(公告)号：US20230079760A1

公开(公告)日：2023-03-16

申请号：US17473119

申请日：2021-09-13

Applicant: MEDTRONIC INC.

Inventor： JONATHAN T. GOODMAN ,  Sean Chen ,  Kasyap V. Seethamraju ,  Charlene X. Yuan ,  Raman V. Bahulekar

IPC: A61L31/16 ,  A61L31/04

Abstract: A surgical device includes a substrate and a first coating that covers at least a portion of the substrate. The first coating includes a first polymer. The first coating having antibiotics dispersed in the first polymer such that the first polymer releases the antibiotics as the first polymer degrades. A second coating covers at least a portion of the first coating. The second coating includes a second polymer. The second coating has ellagic acid dispersed in the second polymer such that the second polymer releases the ellagic acid as the second polymer degrades. In some embodiments, systems and methods are disclosed.

公开(公告)号：US20230077402A1

公开(公告)日：2023-03-16

申请号：US17473123

申请日：2021-09-13

Applicant: MEDTRONIC INC.

Inventor： JONATHAN T. GOODMAN ,  Sean Chen ,  Kasyap V. Seethamraju ,  Charlene X. Yuan ,  Raman V. Bahulekar ,  Joseph L. Kalscheuer

IPC: A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61K31/196 ,  A61K31/496 ,  A61K31/65

Abstract: A surgical device includes a substrate and a first coating that covers at least a portion of the substrate. The first coating includes a first polymer. The first coating having antibiotics dispersed in the first polymer such that the first polymer releases the antibiotics as the first polymer degrades. A second coating covers at least a portion of the first coating. The second coating includes a second polymer. The second polymer includes an alginate. The second coating has a hemostatic agent dispersed in the second polymer such that the second polymer releases the hemostatic agent as the second polymer degrades. The hemostatic agent is selected from epinephrine, tranexamic acid, chitosan and oxidized regenerated cellulose. In some embodiments, systems and methods are disclosed.