专利检索 ap:("Memorial Sloan-Kettering Cancer Center" OR "Sloan-Kettering Institute for Cancer Research" OR "Memorial Hospital for Cancer AND Allied Diseases" OR "Cornell University" OR "The Curators of the University of Missouri") AND inv:"Virginia Aragon" 第 1 页

1.

发明公开
NANOPARTICLE-MEDIATED ENHANCEMENT OF IMMUNOTHERAPY TO PROMOTE FERROPTOSIS-INDUCED CYTOTOXICITY AND ANTITUMOR IMMUNE RESPONSES 审中-公开

公开(公告)号：US20240285543A1

公开(公告)日：2024-08-29

申请号：US18572423

申请日：2022-06-21

申请人： Memorial Sloan-Kettering Cancer Center , Sloan-Kettering Institute for Cancer Research , Memorial Hospital for Cancer and Allied Diseases , Cornell University , The Curators of the University of Missouri

发明人： Michelle S. Bradbury , Michael Overholtzer , Virginia Aragon , Gabriel DeLeon , Ulrich Wiesner , Thomas P. Quinn , Michael R. McDevitt

IPC分类号： A61K9/51 , A61K9/00 , A61K31/519 , A61K39/00 , A61K39/395 , A61K47/69 , A61K51/08 , A61N5/10 , A61P35/00 , C12Q1/6886

CPC分类号： A61K9/5115 , A61K9/0019 , A61K31/519 , A61K39/3955 , A61K39/4611 , A61K39/4631 , A61K47/6929 , A61K51/088 , A61N5/10 , A61P35/00 , C12Q1/6886 , A61N2005/1089 , A61N2005/109 , A61N2005/1098 , C12Q2600/158

摘要： Described herein are methods of treating cancer by administering to a subject a composition comprising ultrasmall silica nanoparticles to enhance one or more of the following immunotherapies: chimeric antigen receptor (CAR) T-cell therapy, immune checkpoint blockade antibody therapy (ICB), immune inhibitor therapy (e.g., myeloid-targeting inhibitors). In some embodiments, the compositions are used in combination with external beam radiotherapy.