公开(公告)号：US20240285543A1

公开(公告)日：2024-08-29

申请号：US18572423

申请日：2022-06-21

申请人： Memorial Sloan-Kettering Cancer Center ,  Sloan-Kettering Institute for Cancer Research ,  Memorial Hospital for Cancer and Allied Diseases ,  Cornell University ,  The Curators of the University of Missouri

发明人： Michelle S. Bradbury ,  Michael Overholtzer ,  Virginia Aragon ,  Gabriel DeLeon ,  Ulrich Wiesner ,  Thomas P. Quinn ,  Michael R. McDevitt

IPC分类号： A61K9/51 ,  A61K9/00 ,  A61K31/519 ,  A61K39/00 ,  A61K39/395 ,  A61K47/69 ,  A61K51/08 ,  A61N5/10 ,  A61P35/00 ,  C12Q1/6886

CPC分类号： A61K9/5115 ,  A61K9/0019 ,  A61K31/519 ,  A61K39/3955 ,  A61K39/4611 ,  A61K39/4631 ,  A61K47/6929 ,  A61K51/088 ,  A61N5/10 ,  A61P35/00 ,  C12Q1/6886 ,  A61N2005/1089 ,  A61N2005/109 ,  A61N2005/1098 ,  C12Q2600/158

摘要： Described herein are methods of treating cancer by administering to a subject a composition comprising ultrasmall silica nanoparticles to enhance one or more of the following immunotherapies: chimeric antigen receptor (CAR) T-cell therapy, immune checkpoint blockade antibody therapy (ICB), immune inhibitor therapy (e.g., myeloid-targeting inhibitors). In some embodiments, the compositions are used in combination with external beam radiotherapy.

公开(公告)号：US12070625B2

公开(公告)日：2024-08-27

申请号：US17984954

申请日：2022-11-10

申请人： TAE TECHNOLOGIES, INC.

发明人： Alexander Dunaevsky ,  Artem N. Smirnov ,  Alexandr A. Ivanov ,  Vladislav Vekselman

IPC分类号： A61N5/10 ,  H05H5/03 ,  H05H5/06

CPC分类号： A61N5/1077 ,  A61N5/1048 ,  H05H5/03 ,  H05H5/063 ,  A61N2005/109 ,  A61N2005/1095

摘要： Embodiments of systems, devices, and methods relate to a beam system. An example beam system includes a charged particle source configured to generate a beam of charged particles, a pre-accelerator system configured to accelerate the beam, and an accelerator configured to accelerate the beam from the pre-accelerator system. The pre-accelerator system can cause the beam to converge as it is propagated from the source to an input aperture of the accelerator. The pre-accelerator system can further reduce or eliminate source disturbance or damage caused by backflow traveling from the accelerator toward the source.

公开(公告)号：US12062463B2

公开(公告)日：2024-08-13

申请号：US17302412

申请日：2021-05-03

申请人： Neutron Therapeutics LLC

发明人： William H. Park, Jr. ,  Steven P. Konish ,  Theodore H. Smick ,  Takao Sakase

IPC分类号： H05H6/00 ,  G21G1/10 ,  G21G4/02 ,  G21K5/08 ,  G21K5/10 ,  H05H3/06 ,  A61N5/10

CPC分类号： G21G4/02 ,  G21G1/10 ,  G21K5/08 ,  G21K5/10 ,  H05H3/06 ,  H05H6/00 ,  A61N5/10 ,  A61N5/1077 ,  A61N2005/1087 ,  A61N2005/109

摘要： Apparatuses and methods for producing neutrons for applications such as boron neutron capture therapy (BNCT) are described. An apparatus can include a rotary fixture with a coolant inlet and a coolant outlet, and a plurality of neutron-producing segments. Each neutron-producing segment of the plurality of neutron-producing segments is removably coupled to the rotary fixture, and includes a substrate having a coolant channel circuit defined therein and a solid neutron source layer disposed thereon. The coolant channel circuits are in fluid communication with the coolant inlet and the coolant outlet.

公开(公告)号：US20240268015A1

公开(公告)日：2024-08-08

申请号：US18334808

申请日：2023-06-14

申请人： Heron Neutron Medical Corp.

发明人： Chih-Chung LIN ,  Siao-Cing LIOU ,  Shan-Haw CHIOU

IPC分类号： H05H7/06 ,  A61N5/10 ,  H05H13/00

CPC分类号： H05H7/06 ,  A61N5/1048 ,  A61N5/1078 ,  H05H13/005 ,  A61N2005/1087 ,  A61N2005/109

摘要： A beam equipment controlling method is provided. The method includes: proton beam regulatory steps, including: generating a first proton beam after confirming that the generating conditions are met, and marking the proton beam regulatory steps as completed after confirming that the first proton beam meets the specifications; neutron beam regulatory steps, including: generating a first neutron beam after confirming that the proton beam regulatory steps are completed and the generating conditions are met, confirming that the first neutron beam meets specifications, and marking the neutron beam regulatory steps as completed after turning off the cyclotron system; and treatment regulatory steps, including: generating a second neutron beam after confirming that the neutron beam regulatory steps are completed and the treatment-beam generating conditions are met, confirming that the second neutron beam meets treatment needs; and marking the treatment regulatory steps as completed after turning off the cyclotron system.

公开(公告)号：US20240238618A1

公开(公告)日：2024-07-18

申请号：US18315784

申请日：2023-05-11

申请人： Heron Neutron Medical Corp.

发明人： Kuan-Yan Huang ,  Shan-Haw CHIOU ,  Chih-Chung LIN ,  Siao-Cing LIOU

IPC分类号： A61N5/10 ,  H05H3/06

CPC分类号： A61N5/1078 ,  A61N5/1075 ,  H05H3/06 ,  A61N2005/1087 ,  A61N2005/109 ,  A61N2005/1094 ,  H05H2242/10

摘要： A neutron beam source generation system, a neutron beam source stabilization control system, and a neutron beam source generation method are provided. The neutron beam source generation system includes an accelerator, a target, and a calibration module. The accelerator is configured to generate a proton beam. A neutron beam source is generated by irradiating the target with the proton beam. The calibration module includes a pair of electromagnet components, a profile-measuring component, a current-measuring component, and a Faraday cup component. The calibration module uses the pair of electromagnet components to control the distribution of the proton beam according to the profile distribution of the proton beam as measured by the profile-measuring component. The calibration module adjusts the current of the proton beam according to the first current value as measured by the current-measuring component, the second current value as measured by the Faraday cup component, or both.

公开(公告)号：US20240139546A1

公开(公告)日：2024-05-02

申请号：US18399913

申请日：2023-12-29

申请人： NEUBORON THERAPY SYSTEM LTD.

发明人： Di-yun SHU ,  Qiu-Ping GONG

IPC分类号： A61N5/10

CPC分类号： A61N5/1065 ,  A61N5/1077 ,  A61N2005/109 ,  A61N2005/1094 ,  A61N2005/1095

摘要： A neutron capture therapy system, which can reduce secondary radiation and radiation damage caused by the action of recoil neutrons generated in the process of generating neutron beams by a beam transmission portion and a neutron beam generation portion. The neutron capture therapy system comprises an accelerator, the beam transmission portion, and the neutron beam generation portion; the accelerator accelerates charged particles to generate charged particle beams; the beam transmission portion transmits the charged particle beams generated by the accelerator to the neutron beam generation portion; the neutron beam generation portion generates neutron beams for treatment; and the neutron capture therapy system comprises a beam transmission shielding component for the beam transmission portion.

公开(公告)号：US20240075319A1

公开(公告)日：2024-03-07

申请号：US18505694

申请日：2023-11-09

申请人： Australian Nuclear Science and Technology Organisation ,  University of Wollongong

发明人： Mitra Safavi-Naeini ,  Andrew Stephen Chacon

IPC分类号： A61N5/10 ,  G21K5/04 ,  H05H7/10 ,  H05H13/04 ,  H05H13/10

CPC分类号： A61N5/1078 ,  A61N5/1065 ,  G21K5/04 ,  H05H7/10 ,  H05H13/04 ,  H05H13/10 ,  A61N2005/1034 ,  A61N2005/1087 ,  A61N2005/109 ,  A61N2005/1098

摘要： An irradiation method and system for irradiating a target volume, the method comprising: providing thermal neutron absorbing nuclides (such as in the form of a high neutron cross-section agent) at the target volume; and producing neutrons by irradiating nuclei in or adjacent to the target volume with a beam of particles consisting of any one or more of protons, deuterons, tritons and heavy ions, thereby prompting production of the neutrons through non-elastic collisions between the atoms in the path of the beam (including the target) and the particles. The neutron absorbing nuclides absorb neutrons produced in the non-elastic collisions, thereby producing capture products or fragments that irradiate the target volume.

公开(公告)号：US11890265B2

公开(公告)日：2024-02-06

申请号：US16363758

申请日：2019-03-25

申请人： SERBIG PHARMACEUTICALS CORP.

发明人： Pedro Anastacio Serrano-Ojeda

IPC分类号： A61K31/07 ,  A61K31/14 ,  A61K31/19 ,  A61K31/51 ,  A61K33/06 ,  A61K33/18 ,  A61K36/28 ,  A61K39/00 ,  A61K31/122 ,  A61K31/194 ,  A01N43/00 ,  A01N43/46 ,  A61K31/55 ,  A61K31/198 ,  A61K31/28 ,  A61N5/10 ,  A61N5/02 ,  A61K41/00 ,  C07F1/00 ,  A61K47/54 ,  A61K31/197 ,  A61K31/355 ,  A61K31/375 ,  A61K31/455 ,  A61K31/519 ,  A61K31/525 ,  A61K31/555 ,  A61K31/593 ,  A61K31/714 ,  A61K31/4415

CPC分类号： A61K31/198 ,  A61K31/28 ,  A61K41/0038 ,  A61K47/542 ,  A61N5/02 ,  A61N5/10 ,  C07F1/00 ,  A61N2005/109 ,  A61N2005/1087

摘要： The present invention is a glutamine compound having a high Z element attached via a ligand, which enters the mitochondrion and is subsequently exposed to ionizing radiation. When exposed to ionizing radiation, the present invention damages mitochondrial (as well as other) substructures such as mtDNA, the outer membrane, the inner membrane, cristae, ribosomes, etc., and causes the effective destruction of such mitochondrion. Tumorigenic cells without mitochondria cannot produce the energy they need to subsist and replicate, effectively starving them of energy and causing their destruction.

公开(公告)号：US20240009332A1

公开(公告)日：2024-01-11

申请号：US18228818

申请日：2023-08-01

申请人： RAIKA MEDICAL IMAGING INC.

发明人： Bashir Akhavan TAFTI

IPC分类号： A61K51/12 ,  A61K9/51 ,  A61K49/18 ,  A61N5/10

CPC分类号： A61K51/1251 ,  A61K9/51 ,  A61K49/1887 ,  A61N5/10 ,  A61N2005/109

摘要： The present invention relates to compositions and methods for imaging and treating various diseases and disorders, including cancers. The composition of the invention can include a plurality of biodegradable micro-beads, each embedding a plurality of nano-beads, further including a polymer, a radionuclide, a radionuclide chelator, a radioligand, a chemotherapeutic agent, and a cell-penetrating peptide. Upon injection into a blood vessel supplying a cancer tumor, the micro-beads lodge into the tumor and degrade, releasing the nano-beads with a therapeutic or diagnostic agent. The compositions and methods of the invention provide a more homogeneous and deeper distribution of radiation or chemotherapeutic agents throughout the target tumor. The micro-beads provide a local, sustained, and controlled delivery nano-beads including therapeutic or diagnostic agents.

公开(公告)号：US11826583B2

公开(公告)日：2023-11-28

申请号：US17470145

申请日：2021-09-09

申请人： NEUBORON THERAPY SYSTEM LTD.

发明人： Tao Jiang ,  Wei-lin Chen

IPC分类号： A61N5/10 ,  G21G4/02 ,  G21K5/04 ,  H05H3/06

CPC分类号： A61N5/1078 ,  G21G4/02 ,  G21K5/04 ,  H05H3/06 ,  A61N2005/109 ,  A61N2005/1094

摘要： A neutron capture therapy system is provided, including a neutron generating device and a beam shaping assembly. The neutron capture therapy system further includes a concrete wall forming a space for accommodating the neutron generating device and the beam shaping assembly and shielding radiations generated by the neutron generating device and the beam shaping assembly. A support module is disposed in the concrete wall, the support module is capable of supporting the beam shaping assembly and is used to adjust the position of the beam shaping assembly, and the support module includes concrete and a reinforcing portion at least partially disposed in the concrete. The neutron capture therapy system designs a locally adjustable support for the beam shaping assembly, so that the beam shaping assembly can meet the precision requirement, improve the beam quality, and meet an assembly tolerance of the target.