公开(公告)号：US20150329521A1

公开(公告)日：2015-11-19

申请号：US14649837

申请日：2013-12-04

申请人： Tetsuji ITOH ,  Ingyu JEON ,  Ian MANGION ,  Gang QIAN ,  Benjamin D. SHERRY ,  Donald R. GAUTHIER ,  Yang CAO ,  MERCK SHARP & DOHME CORP.

发明人： Tetsuji Itoh ,  Ingyu Jeon ,  Ian Mangion ,  Gang QIAN ,  Benjamin D. Sherry ,  Donald R. Gauthier ,  Yang CAO

IPC分类号： C07D401/06

CPC分类号： C07D401/06

摘要： The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans.

摘要翻译： 本发明涉及一种合成3-（取代的苯氧基）-1 - [（5-氧代-4,5-二氢-1H-1,2,4-三唑-3-基）甲基]] - 吡啶-2（1H） - 酮衍生物。 通过本发明的方法合成的化合物是可用于抑制逆转录酶，HIV复制和人类免疫缺陷病毒感染治疗的HIV逆转录酶抑制剂。

公开(公告)号：US09663490B2

公开(公告)日：2017-05-30

申请号：US14649837

申请日：2013-12-04

申请人： Merck Sharp & Dohme Corp.

发明人： Tetsuji Itoh ,  Ingyu Jeon ,  Ian Mangion ,  Gang Qian ,  Benjamin D. Sherry ,  Donald R. Gauthier ,  Yang Cao

IPC分类号： C07D401/06

CPC分类号： C07D401/06

摘要： The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans.