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公开(公告)号:US09440952B2
公开(公告)日:2016-09-13
申请号:US14772589
申请日:2014-02-27
发明人: Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Hong Liu , Xing Dai , Joel M. Harris , Bernard Neustadt , Andrew Stamford , Marc Poirier , John A. McCauley , Thomas Greshock , Heather Stevenson , John Sanders , Jonathan Kern
IPC分类号: C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D451/02 , C07D487/10 , C07D491/04 , C07D491/08 , C07D491/056 , C07D498/04 , C07D498/08 , C07D403/04 , C07D491/10 , C07D487/04 , C07D491/107 , C07D491/113
CPC分类号: C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/056 , C07D491/08 , C07D491/10 , C07D491/107 , C07D491/113 , C07D498/04 , C07D498/08
摘要: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
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公开(公告)号:US20160009682A1
公开(公告)日:2016-01-14
申请号:US14772589
申请日:2014-02-27
发明人: Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Hong Liu , Xing Dai , Joel M. Harris , Bernard Neustadt , Andrew Stamford , Marc Poirier , John A. McCauley , Thomas Greshock , Heather Stevenson , John Sanders , Jonathan Kern
IPC分类号: C07D401/04 , C07D491/113 , C07D413/14 , C07D405/14 , C07D487/10 , C07D487/04 , C07D471/10 , C07D491/04 , C07D409/14 , C07D417/14 , C07D498/04 , C07D498/08 , C07D451/02 , C07D491/107 , C07D491/08 , C07D491/056 , C07D401/14
CPC分类号: C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/056 , C07D491/08 , C07D491/10 , C07D491/107 , C07D491/113 , C07D498/04 , C07D498/08
摘要: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
摘要翻译: 本发明涉及作为LRRK2激酶的有效抑制剂的吲唑化合物,可用于治疗或预防其中涉及LRRK2激酶的疾病,例如帕金森病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及LRRK-2激酶的疾病中的用途。
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