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公开(公告)号：US11155619B2
公开(公告)日：2021-10-26
申请号：US16415530
申请日：2019-05-17
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Robert A. Kastelein , David Vlerick
IPC分类号： C07K16/28 , A61K39/395 , C07K16/18 , A61K45/06 , C07K16/46
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US10323090B2
公开(公告)日：2019-06-18
申请号：US15353919
申请日：2016-11-17
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , David Vlerick , Robert A. Kastelein
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , A61K45/06 , C07K16/18
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US20190338025A1
公开(公告)日：2019-11-07
申请号：US16415530
申请日：2019-05-17
发明人： Edward Bowman , Maribal Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Robert A. Kastelein , David Vlerick
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395 , C07K16/46 , C07K16/18
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US11168136B2
公开(公告)日：2021-11-09
申请号：US16415496
申请日：2019-05-17
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Robert A. Kastelein , David Vlerick
IPC分类号： C07K16/28 , A61K39/395 , C07K16/18 , A61K45/06 , C07K16/46
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US11168135B2
公开(公告)日：2021-11-09
申请号：US16415455
申请日：2019-05-17
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Robert A. Kastelein , David Vlerick
IPC分类号： C07K16/28 , C07K16/18 , A61K39/395 , A61K45/06 , C07K16/46
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US10544222B2
公开(公告)日：2020-01-28
申请号：US15353867
申请日：2016-11-17
发明人： Juha Punnonen , Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Bjorn Victor , David Vlerick , Robert A. Kastelein
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US20190330340A1
公开(公告)日：2019-10-31
申请号：US16415496
申请日：2019-05-17
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Robert A. Kastelein , David Vlerick
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395 , C07K16/46 , C07K16/18
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US20190330339A1
公开(公告)日：2019-10-31
申请号：US16415455
申请日：2019-05-17
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Robert A. Kastelein , David Vlerick
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395 , C07K16/46 , C07K16/18
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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