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公开(公告)号：US11155619B2
公开(公告)日：2021-10-26
申请号：US16415530
申请日：2019-05-17
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Robert A. Kastelein , David Vlerick
IPC分类号： C07K16/28 , A61K39/395 , C07K16/18 , A61K45/06 , C07K16/46
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US10323090B2
公开(公告)日：2019-06-18
申请号：US15353919
申请日：2016-11-17
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , David Vlerick , Robert A. Kastelein
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , A61K45/06 , C07K16/18
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US20140302061A1
公开(公告)日：2014-10-09
申请号：US14356029
申请日：2012-10-31
发明人： Maribel Beaumont , Jeanine D. Mattson , Jennifer R. Louten , Terrill K. McClanahan , Rene de Waal Malefyt
IPC分类号： C07K16/24 , G01N33/543
CPC分类号： C07K16/24 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/54306 , G01N33/6863 , G01N2800/24 , G01N2800/52
摘要： The present invention relates to biomarker responsive to treatment with a TSLP antagonist.
摘要翻译： 本发明涉及响应于用TSLP拮抗剂治疗的生物标志物。
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公开(公告)号：US09732151B2
公开(公告)日：2017-08-15
申请号：US14356029
申请日：2012-10-31
发明人： Maribel Beaumont , Jeanine D. Mattson , Jennifer R. Louten , Terrill K. McClanahan , Rene de Waal Malefyt
IPC分类号： C07K16/24 , G01N33/543 , G01N33/68 , C12Q1/68
CPC分类号： C07K16/24 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/54306 , G01N33/6863 , G01N2800/24 , G01N2800/52
摘要： The present invention relates to biomarker responsive to treatment with an anti-Thymic Stromal Lymphopoietin (TSLP) antibody.
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公开(公告)号：US20150368344A1
公开(公告)日：2015-12-24
申请号：US14744706
申请日：2015-06-19
发明人： Barbara Joyce-Shaikh , Douglas C. Wilson , Daniel J. Cua , Drake M. LaFace , Maribel Beaumont , Holly Cherwinski , Mark Hsieh , Sabrina Benchaar , Joseph H. Phillips
IPC分类号： C07K16/28 , C07K14/705 , G01N33/50
CPC分类号： C07K16/2851 , A61K2039/505 , C07K14/7056 , C07K2317/76 , C07K2319/00 , G01N33/5008 , G01N33/5041 , G01N33/505 , G01N33/56972 , G01N2333/4724 , G01N2440/14 , G01N2500/02 , G01N2500/10
摘要： The invention provides methods for modulation interactions between MDL-1 and its binding partner, Gal9. Also provided are methods to screen for modulators of MDL-1/Gal9 interaction.
摘要翻译： 本发明提供了MDL-1与其结合配偶体Gal9之间调节相互作用的方法。 还提供了筛选MDL-1 / Gal9相互作用的调节剂的方法。
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公开(公告)号：US20140206563A1
公开(公告)日：2014-07-24
申请号：US14160414
申请日：2014-01-21
发明人： Maribel Beaumont
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6881 , G01N2333/78 , G01N2800/52 , H01J49/00 , H01J49/0036
摘要： A group of polypeptides that are modulated in a psoriatic sample as compared to a normal sample is provided. These polypeptides can be used as biomarkers for diagnosis and monitoring treatment of psoriasis.
摘要翻译： 提供了与正常样品相比在银屑病样品中调节的一组多肽。 这些多肽可用作诊断和监测银屑病治疗的生物标志物。
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公开(公告)号：US11168136B2
公开(公告)日：2021-11-09
申请号：US16415496
申请日：2019-05-17
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Robert A. Kastelein , David Vlerick
IPC分类号： C07K16/28 , A61K39/395 , C07K16/18 , A61K45/06 , C07K16/46
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US11168135B2
公开(公告)日：2021-11-09
申请号：US16415455
申请日：2019-05-17
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Robert A. Kastelein , David Vlerick
IPC分类号： C07K16/28 , C07K16/18 , A61K39/395 , A61K45/06 , C07K16/46
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US10544222B2
公开(公告)日：2020-01-28
申请号：US15353867
申请日：2016-11-17
发明人： Juha Punnonen , Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Bjorn Victor , David Vlerick , Robert A. Kastelein
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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公开(公告)号：US20190330340A1
公开(公告)日：2019-10-31
申请号：US16415496
申请日：2019-05-17
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Robert A. Kastelein , David Vlerick
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395 , C07K16/46 , C07K16/18
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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