公开(公告)号：US20220095610A1

公开(公告)日：2022-03-31

申请号：US17545118

申请日：2021-12-08

申请人： Merck Sharp & Dohme Corp.

发明人： Jeffrey Charles JOHNSON ,  Anthony FLAMMINO ,  Mark Anton PETRICH ,  Scott MCFEATERS ,  John H. ROOSA, JR. ,  Robert Ian ALPERN ,  Joseph W. LOCURCIO ,  Matthew H. FLAMM

IPC分类号： A01N1/02 ,  A61J1/00 ,  B65D81/00

摘要： Container system and method for freezing (and subsequently thawing) a liquid such as a drug substance, such that all containers in a set have a uniform width, hence uniform freeze-path length, in the widthwise direction and perpendicular to major walls of the containers, irrespective of the particular length, height, and volumetric capacity of the various containers in the set. This leads to uniform freezing performance and thereby reduces cryoconcentration. The system also eliminates or reduces ice-bridging, and the potential for containers rupturing during freezing and thawing operations.

公开(公告)号：US20190191693A1

公开(公告)日：2019-06-27

申请号：US16326958

申请日：2017-08-21

申请人： Merck Sharp & Dohme Corp.

发明人： Jeffrey Charles JOHNSON ,  Anthony FLAMMINO ,  Mark Anton PETRICH ,  Scott MCFEATERS ,  John H. ROOSA, JR. ,  Robert Ian ALPERN ,  Joseph W. LOCURCIO ,  Matthew H. FLAMM

IPC分类号： A01N1/02

CPC分类号： A01N1/0268 ,  A01N1/0263 ,  A01N1/0273 ,  A61J1/00 ,  B65D81/00 ,  B65D81/027 ,  B65D81/18 ,  B65D81/24

摘要： Container system and method for freezing (and subsequently thawing) a liquid such as a drug substance, such that all containers in a set have a uniform width, hence uniform freeze-path length, in the widthwise direction and perpendicular to major walls of the containers, irrespective of the particular length, height, and volumetric capacity of the various containers in the set. This leads to uniform freezing performance and thereby reduces cryoconcentration. The system also eliminates or reduces ice-bridging, and the potential for containers rupturing during freezing and thawing operations.