公开(公告)号：US09403807B2

公开(公告)日：2016-08-02

申请号：US14557980

申请日：2014-12-02

Applicant: Merck Sharp & Dohme Corp.

Inventor： Alejandro Crespo ,  Ping Lan ,  Rudrajit Mal ,  Anthony Ogawa ,  Hong Shen ,  Peter J. Sinclair ,  Zhongxiang Sun ,  Ellen K. Vande Bunte ,  Zhicai Wu ,  Kun Liu ,  Robert J. DeVita ,  Dong-Ming Shen ,  Min Shu ,  John Qiang Tan ,  Changhe Qi ,  Yuguang Wang ,  Richard Beresis

IPC: C07D413/06 ,  C07D231/56 ,  A61K31/404 ,  A61K31/416 ,  C07D403/06 ,  C07D209/08 ,  C07D209/10 ,  A61K31/405 ,  A61K31/4196 ,  A61K31/722 ,  A61K31/4245 ,  A61K45/06 ,  C07D403/04 ,  C07D405/06 ,  A61K31/4045 ,  A61K31/422

CPC classification number: C07D413/06 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/405 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K45/06 ,  C07D209/08 ,  C07D209/10 ,  C07D231/56 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06

Abstract: The present invention is directed to compounds of the Formula I as well as pharmaceutically acceptable salts thereof, that are useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula I.

Abstract translation: 本发明涉及可用于治疗醛固酮介导的疾病的式I化合物及其药学上可接受的盐。 本发明还涉及制备式I化合物的方法，其用于治疗和预防上述疾病和用于制备用于此目的的药物，以及包含式I化合物的药物组合物。

公开(公告)号：US20150284376A1

公开(公告)日：2015-10-08

申请号：US14557980

申请日：2014-12-02

Applicant: Merck Sharp & Dohme Corp.

Inventor： Alejandro Crespo ,  Ping Lan ,  Rudrajit Mal ,  Anthony Ogawa ,  Hong Shen ,  Peter J. Sinclair ,  Zhongxiang Sun ,  Ellen K. Vande Bunte ,  Zhicai Wu ,  Kun Liu ,  Robert J. DeVita ,  Dong-Ming Shen ,  Min Shu ,  John Qiang Tan ,  Changhe Qi ,  Yuguang Wang ,  Richard Beresis

IPC: C07D413/06 ,  A61K31/405 ,  C07D231/56 ,  A61K31/416 ,  A61K31/4045 ,  A61K45/06 ,  C07D403/06 ,  A61K31/4196 ,  A61K31/422 ,  C07D403/04 ,  A61K31/404 ,  C07D405/06 ,  C07D209/08 ,  A61K31/4245

CPC classification number: C07D413/06 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/405 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K45/06 ,  C07D209/08 ,  C07D209/10 ,  C07D231/56 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06

Abstract: The present invention is directed to compounds of the Formula I as well as pharmaceutically acceptable salts thereof, that are useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula I.

Abstract translation: 本发明涉及可用于治疗醛固酮介导的疾病的式I化合物及其药学上可接受的盐。 本发明还涉及制备式I化合物的方法，其用于治疗和预防上述疾病和用于制备用于此目的的药物，以及包含式I化合物的药物组合物。