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公开(公告)号:US10143681B2
公开(公告)日:2018-12-04
申请号:US15681478
申请日:2017-08-21
发明人: Dong-Ming Shen , Rongze Kuang , Puneet Kumar , Joseph L. Duffy , Cheng Zhu , Amjad Ali , Meng Yang , John S. Debenham
IPC分类号: A61K31/4412 , C07D213/89 , A61K31/435
摘要: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US20180050022A1
公开(公告)日:2018-02-22
申请号:US15681478
申请日:2017-08-21
发明人: Dong-Ming Shen , Rongze Kuang , Puneet Kumar , Joseph L. Duffy , Cheng Zhu , Amjad Ali , Meng Yang , John S. Debenham
IPC分类号: A61K31/435 , C07D213/89
CPC分类号: A61K31/435 , A61K2121/00 , C07D213/89
摘要: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US10093683B2
公开(公告)日:2018-10-09
申请号:US15305421
申请日:2015-04-21
发明人: Yeon-Hee Lim , Zhuyan Guo , Amjad Ali , Scott D. Edmondson , Weiguo Liu , Gioconda V. Gallo-Etienne , Heping Wu , Ying-Duo Gao , Andrew W. Stamford , Younong Yu , Nancy J. Kevin , Rajan Anand , Deyou Sha , Santhosh F. Neelamkavil , Zahid Hussain , Puneet Kumar , Remond Moningka , Joseph L. Duffy , Jiayi Xu , Yu Jiang , Anjan Chakrabarti , Hiroki Sone
IPC分类号: C07D498/20 , C07F9/6561 , C07D487/10 , C07D498/10 , C07D471/10
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more compounds of Formula (I), and methods for using the compounds of Formula (I) for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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