公开(公告)号：US10143681B2

公开(公告)日：2018-12-04

申请号：US15681478

申请日：2017-08-21

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Dong-Ming Shen ,  Rongze Kuang ,  Puneet Kumar ,  Joseph L. Duffy ,  Cheng Zhu ,  Amjad Ali ,  Meng Yang ,  John S. Debenham

IPC: A61K31/4412 ,  C07D213/89 ,  A61K31/435

Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US20180050022A1

公开(公告)日：2018-02-22

申请号：US15681478

申请日：2017-08-21

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Dong-Ming Shen ,  Rongze Kuang ,  Puneet Kumar ,  Joseph L. Duffy ,  Cheng Zhu ,  Amjad Ali ,  Meng Yang ,  John S. Debenham

IPC: A61K31/435 ,  C07D213/89

CPC classification number: A61K31/435 ,  A61K2121/00 ,  C07D213/89

Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US10093683B2

公开(公告)日：2018-10-09

申请号：US15305421

申请日：2015-04-21

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yeon-Hee Lim ,  Zhuyan Guo ,  Amjad Ali ,  Scott D. Edmondson ,  Weiguo Liu ,  Gioconda V. Gallo-Etienne ,  Heping Wu ,  Ying-Duo Gao ,  Andrew W. Stamford ,  Younong Yu ,  Nancy J. Kevin ,  Rajan Anand ,  Deyou Sha ,  Santhosh F. Neelamkavil ,  Zahid Hussain ,  Puneet Kumar ,  Remond Moningka ,  Joseph L. Duffy ,  Jiayi Xu ,  Yu Jiang ,  Anjan Chakrabarti ,  Hiroki Sone

IPC: C07D498/20 ,  C07F9/6561 ,  C07D487/10 ,  C07D498/10 ,  C07D471/10

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more compounds of Formula (I), and methods for using the compounds of Formula (I) for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.