公开(公告)号：US20170240523A1

公开(公告)日：2017-08-24

申请号：US15329635

申请日：2015-07-23

申请人： Merck Sharp & Dohme Corp.

发明人： Weiguo Liu ,  Scott D Edmondson ,  Zhuyan Guo ,  Alan Hruza ,  Sung-Sau So ,  Wanying Sun ,  Amjad All ,  Rongze Kuang ,  Ying-Duo Gao ,  Anthony K Ogawa

IPC分类号： C07D401/06 ,  C07D401/14

CPC分类号： C07D401/06 ,  C07D401/14

摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US10011585B2

公开(公告)日：2018-07-03

申请号：US15329635

申请日：2015-07-23

申请人： Merck Sharp & Dohme Corp.

发明人： Weiguo Liu ,  Scott D Edmondson ,  Zhuyan Guo ,  Alan Hruza ,  Sung-Sau So ,  Wanying Sun ,  Amjad Ali ,  Rongze Kuang ,  Ying-Duo Gao ,  Anthony K Ogawa

IPC分类号： C07D401/06 ,  C07D401/14

CPC分类号： C07D401/06 ,  C07D401/14

摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.