公开(公告)号：US20150119394A1

公开(公告)日：2015-04-30

申请号：US14387935

申请日：2013-03-14

Applicant: Merck Sharp & Dohme Corp. ,  Piramal Enterprises Limited

Inventor： Abhijit Roychowdhury ,  Rajiv Sharma ,  Malcolm Mascarenhas ,  Chandrika B-Rao ,  Shashikant M. Patil ,  Sambhaji Chavan ,  Nitin Lad ,  Smriti Khanna ,  Christopher J. Dinsmore

IPC: C07D413/12 ,  C07D413/14

CPC classification number: C07D413/12 ,  C07D413/14

Abstract: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating Insulin-Like-Growth Factor I Receptor and Insulin Receptor. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.

Abstract translation: 本发明涉及能够抑制，调节和/或调节胰岛素样生长因子I受体和胰岛素受体的化合物。 本发明的化合物具有包含磺酰基吲哚部分的核心结构。 本发明还涉及这些化合物的药学上可接受的盐，水合物和立体异构体。