公开(公告)号：US20230312528A1

公开(公告)日：2023-10-05

申请号：US18329108

申请日：2023-06-05

申请人： Merck Sharp & Dohme LLC

发明人： Ashok Arasappan ,  Ian M. Bell ,  Christopher James Bungard ,  Christopher S. Burgey ,  Jason M. Cox ,  Michael J. Kelly, III ,  Mark E. Layton ,  Hong Liu ,  Jian Liu ,  James J. Perkins ,  Akshay A. Shah ,  Michael David VanHeyst ,  Zhe Wu

IPC分类号： C07D403/12 ,  C07D233/32 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D513/04

CPC分类号： C07D403/12 ,  C07D233/32 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D513/04

摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

公开(公告)号：US20220289710A1

公开(公告)日：2022-09-15

申请号：US17752419

申请日：2022-05-24

申请人： Merck Sharp & Dohme LLC

发明人： Ashok Arasappan ,  Ian M. Bell ,  Michael J. Breslin ,  Christopher James Bungard ,  Christopher S. Burgey ,  Harry R. Chobanian ,  Jason M. Cox ,  Anthony T. Ginnetti ,  Deodial Guy Guiadeen ,  Kristen L.G. Jones ,  Mark E. Layton ,  Hong Liu ,  Jian Liu ,  James J. Perkins ,  Shawn J. Stachel ,  Linda M. Suen-Lai ,  Zhe Wu

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D471/08 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04

摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.