公开(公告)号：US20220289710A1

公开(公告)日：2022-09-15

申请号：US17752419

申请日：2022-05-24

申请人： Merck Sharp & Dohme LLC

发明人： Ashok Arasappan ,  Ian M. Bell ,  Michael J. Breslin ,  Christopher James Bungard ,  Christopher S. Burgey ,  Harry R. Chobanian ,  Jason M. Cox ,  Anthony T. Ginnetti ,  Deodial Guy Guiadeen ,  Kristen L.G. Jones ,  Mark E. Layton ,  Hong Liu ,  Jian Liu ,  James J. Perkins ,  Shawn J. Stachel ,  Linda M. Suen-Lai ,  Zhe Wu

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D471/08 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04

摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

公开(公告)号：US20240018145A1

公开(公告)日：2024-01-18

申请号：US18015465

申请日：2021-07-22

申请人： Merck Sharp & Dohme LLC ,  COCRYSTAL PHARMA, INC.

发明人： Yonglian Zhang ,  John A. McCauley ,  Michael Man-Chu Lo ,  Liangqin Guo ,  Kake Zhao ,  Frank Bennett ,  Ronald M. Kim ,  Reynalda Keh DeJesus ,  Valerie W. Shurtleff ,  Manuel de Lera Ruiz ,  Michael Plotkin ,  Hua Su ,  James Fells ,  Brendan M. Crowley ,  Harry R. Chobanian ,  Mark W. Embrey ,  Gregori J. Morriello

IPC分类号： C07D471/14 ,  C07D491/22 ,  C07D471/04 ,  A61P31/16

CPC分类号： C07D471/14 ,  A61P31/16 ,  C07D471/04 ,  C07D491/22

摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing influenza. The compounds are cap-dependent endonuclease inhibitors.